v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) DNM3 opposite strand/antisense RNA (DNM3OS) URS000075EFF6_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

DNM3OS: DNM3OS is a long non-coding RNA (lncRNA) encoded by an independent transcription unit located on chromosome 1 and embedded in the intron of the Dynamin 3 gene [PMC3430244]. It is involved in various biological processes and has been implicated in tumorigenesis and cancer progression [PMC8149934]. In ovarian cancer (OC), DNM3OS is upregulated and its high expression is associated with shorter overall survival [PMC8149934]. In esophageal squamous cell carcinoma, DNM3OS enhances radioresistance by regulating the DNA damage response [PMC9556215]. It has also been shown to facilitate tumor growth and metastasis in oral cancer through modulation of a microRNA (miR)-204-5p/HIP1 molecular axis [PMC9556215]. In addition, DNM3OS has been found to be upregulated in gastrointestinal stromal tumors (GISTs) and correlated with worse prognosis in patients with GISTs [PMC8254811]. Furthermore, an interaction region between SPINT1-AS1 and DNM3OS has been predicted by the RNA-RNA interaction tool IntaRNA [PMC8326843]. Silencing nucleolin increased the gene expression of inflammatory factors induced by DNM3OS, such as IL-6, suggesting a role for DNM3OS in inflammation [PMC7768882]. DNM3OS also plays a role in chondrogenesis, as its silencing decreased TGFβ1-induced protein levels of COL3A1, a marker of chondrogenesis [PMC6874426]. Pharmacological approaches targeting DNM3OS have shown promise for preventing lung fibrosis and improving established pulmonary fibrosis [PMC9664248]. Overall, understanding the molecular mechanisms involving DNM3OS may provide insights into effective treatment strategies for various diseases.

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset 

CUUUUCCUGGUCCUAAAUUCAUUGCCAGUUCCCCAGUCUGCAGCAAAUGUGCCACGUCAAGACUGGAAAUCACAGCCCUUGAGUGUGUCUCAGUCAGCGCAGCAGAAUUCAGGGGGGAAAGCUGAAUGCAACCCCUGGUGCAGGAAGGGAGGCUUUUCCUGAGGACCGGGAGAGGAUUUUAAGUACAUAGAAGGAAGCUUCUGGAGAUCCUGCUCCGUCGCCCCAGUGUUCAGACUACCUGUUCAGGACAAUGCCGUUGUACAGUAGUCUGCACAUUGGUUAGACUGGGCAAGGGAGAGCAACGCCAUGGACCGCUGGGGACAAAAUGGGCUGUUUCCAAGGAGAAGACAUUUGUUUGCUCCUUUUUUGAAUCUCAUAUCCAGUGUUUUUCUUCACAGGUUUUGCACACUAGGGACCAAGAAGCCCUCGGGGACACUGCUGAGAAAAGACUGCCGAAGGGAAGACCAGCGGGUAAGGCCUUCUUGACUGCUCACCUGGUCUGUGACCAAGGGAACCUAGGUGGGGAGCCCAUGAUUUGUGUUAACAUGCAAGGGAAACAGAGGUACAUGUGUGAUGGGUAGAGAUGUAUUUAAUUUUAAAAGAGCAAAAGUGUGUGGUAUAUAGCGAUUUACUGUUUUUUUUUUUUUUAUUUCUGAAGAUUGAUAAUUCAAGUGUUUUCUUAAAGGUUUUCCCACUUCAAAAUGAAAUAUGAAAAAACUCAUUCCAGACACUUAAGAAUAGUUUAAUGAGGCUACUUUUGAAUUGUUUAAUAAUAAUUCAAAGAUUUAAAAACUUAUAUGGAUGAAGGCUGUAUGUAUAACUUUUAACAUCCCAGGACUGAAGUCAUUUUUCCCCAAAGUAAAGAAUACUUGCUGGUUUUUAAAUGCUAUAUGGAUAGUGCUUUUCUGAAGAUUUCCUUCUGUAAUAUAAACAACAGGAAUAAUAGUACCUAACAAUAAAAGAAGAACCUGCCAAGUCUUGCCUACCAGACAAUGCAGAUGGGAUUUGCCCAGAGAAGAGCACCGACCCACAACUUAUUGAGUCAGCAACUGAGUAAAUCAGGGAAUAAAAACCUCUAUCUUUAGAUACCCCUGUAAAUAUCUGUUUUACAUUUUUUUUAAAUCAAAGAGUGGUUAAUAAUUGCUGCUCAGCUGAGCCCUCUUGCCUAUAGCUUACAAUGCUUCCACUUCUCUGAGCAUUUAAAAUAAGGCACUUUGUCUAGAAACCCACUGAUAAAAAAGGAAUUUGUAAACGAAGGCAGAAGUUUUCUUUGGUCAGUUUCCAGCUGUCCUGGAGGUGAAAGAGGGUGGGAGAGGGGGAGGAAGGUGGGAGGGAAGAAAACCCUCAAGCUGAAUGAAAUCCUAAUAGAGAAAAUAAUAGAGCAAGUCUGGAUUGCAAUGUGAUCUGUGCUGAACUUUAGAGGUCGGCCCCUUAAAGAAAGUUCUGGAAAAAUGUUAUUGCCUCAUCCCUAAUUUUCUUAACCCCCAUUAAUUUCUAUUCCGAAACAAUUCUAUAUAAUGAAAACAUCUCUUCUACAGGGUUUGUGAAAAAUAAACAUAAUCUCUUUUGUCCUCCUUUAAAGUUACAGUGGUUCCUGAACAAAUUCUUUUCUAAGUUAUACAUUUUGCAACAAUUCAAAAAUUGACUCAAGUUCUCUUUAGCAAAAUAUUUUAUUAUAAAAGAUUCCCUAAGUUUUCUUUUGUCAAAACAACUUACUUUAAAAAUUACCCUUCUGAUCACCCCAAAAUGUGUAUAAAGAAAACAUUAAGUAUUCUCAUAUAUUCAUGAUUAUUAGUUAAAAUAUAAACAGCAAGGAGAAAUUUAGCUACUUUCACUUAGAUGAUAUAGUAAAGUUAUCCUUUCAUUUUCUAUUGUGACUUGGAGAGUUCCAUAUUAAUUAUUUUUAGUAGAACAAAUGAGAUGUUAAAAAUCUAUAUAGUUUCUUUUACAUAAGAAAACUAAAAAAAGUAACUUAGAGGAGCUCAUUUUUUCAAGAAAUAUAUUUUUUCUAAUUGAUACAAUUACUGAAGAGGAAAAAUAGCUAACAAGGUACUUUGGUAAUGUUUUUCUCAAAUUUUCUGGGUUUUUUUUUUUUUUUUACUCUAGAAAUGAUUACAUUUCAAAAUUUGCUUUCAUUUAAUGUAUAUUUAAUUUCAAUUUCUUUCUUCAUGUUAAACGGUCUUUUUGUUUCAAAGAAAUGAAUCCCUAUGGGUCCCUCACCUAUUUUCUCCCUCAGGAUGACUUUUAGUCUGGAGAUAGAAGGGACAUAAGGGUGCCUCUGGCAUAAGUACAGGAGUAGAAAUAUAAGAAUUACUUUGUAAAAGGAUAACCAAGGAGUUCCUGCACAUGCUUGAUGUGGCUCUAGCGACUUAUUUUCGAGGCAAAGUUUUAACAAAUGAAAACGAAUAGUACUUAUUUUUCAAUUAUAUGGGCUAAAUUAAAGAUCAAAGGUAAAAGCUCAUUUUAUAAAGCUCUGCUGAAUGAAGGCAGGAUUGUAGUUUAUGCGCUGGUACACACGCCCACAUUUAUAUACAUUAUAGCCAUAUCUAUAUCCAGGUAAAUUAGAAAAAUGUUUAAUUUUAUUUUCAUAUUACUUUAUAAGGAGAUAUACAAAUAUUUUAGGGAUCAUGGAAUCUAUUCCAGAGGAAACUAACCAACAGUGAGCAUCUUCAACUAAAACUACCCCUGGAUGUAAUAAGUGUAAGUAUUAAAAUUAAACAUUAUAUGUGGUCAUGAAGAGAAAAUUGUUUCAGGGUCUGUCCAAACUACACUUCAUAGAAAUUUCAUAAUUAUUUUUCAUUUUAGCAUGUGAAUGAUUGAUAAAUUGGACUAGGUACUGGGUUAAAAGGACUUUUCCACCAUCUAAGAGAAAGGAAGUUCAGAGCCUUAGCUUCAACACCACAAUUUCUUAACUGGAAAAGGAUCAAUCUAAAACGGUGGACUUAAAUUUUCAAACUCAUUUUUCUUUUAGGCCACAGAUCUCAAAAUCAAAGAAAGACUGUUUACUAUAGGACAAAGUUUCACACUGAUCACUUUCCUGUAGUUAGUCAAUAGGCUUAAUAUCCUUCCUGCUUGGCAUUCGGGCUUUCGGCCCAGAUAAUAUGUUUAUGUUUGUAAAAGACCAAAAUAUACUAUCUACCCCCACCUCUCGCCUACAGACCACCCAUGUAUUUCACUCUGUGGGAAACAGUUUAGGCAUAAAAAUCCUAACGAAAGAAUUCUCCCCACUUUUUUGGUUGAAGUCUUAAGCUGUUAUAAGAUAUAAAAAGUACAACUUGGUAAUGUGAAAAAAUUCACUCAUCCACAAGCAUCCAUGCUCGGUAAAGAGACGCCAAAGCUUUCACUUACUCUGUAAGGGAUCUGCUCUUUAUAAACAAUGCACUUUACUCUGCUCUAAGGAGAAUAGCCCACCCAUCACAAUAACGUCAAAAUAAUAACUAAGAGACCAUCACUCAGAAAUCCUGGCUUAAAAUAACUAGAAGGUCAGGCUUUAACCUGAGACAGGAAAUUCCUGAGUUAAGAUAGAAACUUUCUUACUUCAAAUCCCUUCUUACUUUCAUGUUCUGUAAAUUAAGUAGAAAUAAAUAUUUACUCAUUUUCAAAGGUCUCUUACAAAUAAUUUUUAUCAGUUUUAAUAGUUAGAGAUAACGAAGUAAAUUAGGAAAAAUAAUUAAAUCUUCAUUUUGAAUUUUUUGACUUAGCGUGACAGCCAGUUUCCUGGAGUUGCUUUGGUUUAAUUUCACUACAGAAGACUUAGAAGACAAUUCUUUUCUUACAUUUUUUUCCUUAAGAAAUAAAAGACAAAAAGAAAACAAGGUGUAAUAACCACACUAAAAAUUACAUGGUAUGAUAAUAAUACAAAUAGCUCUUUUAUGUUUUAGCUAGUAUUUUAAGUAAUAAUAAACUAAUAUUCAACCUAUAAUUUGGGAGAUUAAAAAAAGGUCAAUAUGGUUUUCAGUCUUUCAUCUUUUUAACAAGUUUAGGGGCAGGUUCAACAUAACAAUGAAGUGUGCAUAUGUCACAUAGUUACUGUAAGUGUGUUUUAAAAAUCUAUCAGAAACAUAAAUUGUCCAAAAGCCUUAUGAAUAGAACAAUUGUUUUCAGCAAGAUUUUUUUUUUCCCCUGAAAAACUGUUGUGGUUUUUCUGGCUCAAAAAAUUUUUAUAUCUUGCCUUAAUAAAACUGUUUUAUAUUAAAGCAUAACAUACAAACUCACAAAUAUUUCUUUUUAUUUUUUCAGGUUGCAUGCAUCAUUCCUUUAAUUGAGCAGAGUUAACUGGAUCAAAUUAUUUAUGGGAGAGAGAGGAAAAGUUAUAAAGAAUUAUAGUAAUUUUUAAUUUCCACCAAUAUACUCUUUGUAAGUGAAUCACUCUAUAAUUACUUUCUGUUGCACUGAAUGCAGCAACAAUAACACAAUAGUAUUUUAAGGCACUGGUUUUUGGCAUACUCUAACCUUGUAAUUAUUUAAAUAACAGCCAAGUUUACUCAUGUUUUUGAUUCUGUCAAGAAAAAAAAAAAGUUCCUUUACUCGAAAGUGAUGGCCGAAACAGAAUCGGAAAUUUGUUUUCUUGAAAUUACAUAAAUACACAGAAAAUGGCACUUAUUAGCUUUUGUUAAAACAUUACCUUACCUAAUCACUGCAUAAAAGUCCAGAUUUGUAGAAAAUUGUAAUUUUCUCAGUAUCUAAAACUAUUUUGCUUUCCAUUAAGUUUCUAUUUGCUAUUUUCUCAGAAUUUUACAAUUAAAGAUAAAUCACAAACUGUUUGUUUUUCUUAAAGUUCUUUGAGAAAAUGUCUAAUUAUACAAUCCUUGGACAAUACUGUGUUUUUUUGGUGCUGUGUUUUUUAAGAAGUCCUACUUACUGGAAUUUUGACUAUUUGGAUAUUUUUGUUUUUAAAAGGGGAGGGGAAUUUGCUUAAUACUUCUAAAGAUGUGAAUUGAUAAUUGAUAUUAAAAUAGAAUUACUCUCAACUCACCAGAAUUAAAUUUUAUAUCUGCAUAUUUAACACUAUUAGCUCAUAUAAAUUAUAAGAAAAAUUUUCAAAGGAUCUGGUUUUAAUUUUUUGGAUAUGAAAUGAAUUUGCCUUUUCUGCCUUUUCUUAAGUACUAUUUUGUAACUAUAUUGCACUAACUAUAUCCAAAACACAUUCUGAGCAUCACUGUGAGUAACAGCCUUCCAGUUUGUACCCUUUUGAUUCACAGCAUGGCCCUAUAGUUAAUUAAGAGGUGGAUAACUUAAGCUCACAACUGCCUUUAAUUUGAUUUCACAUCCACAGUUAUAAACUUUGCAUUUAAAAGGAAAAUGAGACAUUUAAAUAGGUUCCUGUUGUUUCACAUAUAAUUGGUAAAAACAUAUUCCCUUGUAGGAUCCUAUUAUCAGAGCAUCAAAUACCAAAGUCAGCAACUUGGGUUGCCAAAUAAAUUAGGCUCAUUAAUUAUUUUGAAAAGGGCUGCUGUUUCCAUGUAAAUGAUAAUUUUCUUUUUCAUGGACAAGGUUAUGGUACUUAUCUACUAAAAGAAACAUGCAUAAACAUAGUUUUUAUCUUUAACUUCAGUAUUAAAAUAUGCAGUUUUUUGCAAAGAGGAAAAACAUCUGGUUCAAUUACGCUGAACUCUGACUACAUGUGGGCCAGUAAUAAUAUGAAUUGGACUUAAGAAUAAACCUUGUGUUUAAUCUCUUUUUUUCCUUAAAAUUUUAAUGUGAGUUUUCUGUUACGCAAAUUAUCCAUGUUAGCACAUUUGGAACAAAUGUAUAAAUGUACUUUCUGAAUAAAGUCAAAAGUCUAACUUGUUUUUAGUUCCAUAAUGUUUUAAUGUUUAAUUAUAUUGUGUAUUUUUCUCCCUUUCCCCUUACUCUCCAAAAUCACCAAAUCUGGAAAACAGGCUGAUUGUAUCUGUCUAUGAGCAAAGGAAACCUGAAGGAACCAAGGGCCUGGCUGGACAGAGUUGUCAUGUGUCUGCCUGUCUACACUUGCUGUGCAGAACAUCCGCUCACCUGUACAGCAGGCACAGACAGGCAGUCACAUGACAACCCAGCCUGAAUGACAACCAGCCAUUGAAAGAAAGCAGCCCUCACACCAUAGCAUCUACACCAAGAGCUACAACCAAAAUGAGGGGCUCGGGGGCCUGGGGUUUUAAUCUGUUGGUUUAAUACUUAACUCAUGUAUUAUUUUAUUUUGAUUCAAGUAUUAAAACCCACCAAAAGUAAAGUGAGUGGUGCCUAUGAAAUAUAAUAAAACCCAUUUCUGAAAAUGUUCCUGUGCAUUCUAUAGUUCUCUUUUCCUAAUUGUUGUCAGCAAAUCACUACCCUUGACCUUUAUUGUACACAGCUUUGCAGCACCCUAUAUUGAUAUAAAAACUCAAUAUAACAAAACAAUAUAACUUCAGUCUGAUGCUUAACAAAGAAUAAAUUAUUCUAAGAAUUCUUGUCCAUAAACUAAGUAUGGUUUUCUAUGUCAUGAUUUUUUUUUUUUUUUUUUUUUUUUGGAAGGGGAUAGGGUGGAAAGACAGAGAAAAGAAAAGGGAGAAAAAGAGUAUUCCAAAGGAUCAAGUGCUUUGAGUUAACUCUGCCAGUCUGGGUUAACUCUGCCAGUCUGGGUCUGGGCAAAACACAGUGAAAAGACUACUAUUUCCAACUAGUGUUCAACUAUAUUAAAAUAAUAGUUUCUCCUCUUUUGACAUAUGGAAAGUUGAAAUUUUUGAUACUUCCACGCGUCAUGGUAUACAUAAAUUUAUGACUGCGUCAUUCUUUAAUUAAGAAGGUGCUUAUGCUACAGUUCUAGGAGUAGAAUUUACAAGGCCAACACAUUCACUUGCAACCUAUGCUUCCAUCACUAUAAACUUUCAAGAUCUUGAGAUGUUCAGGCAAUUCAUUUAUCUUCAGAAGCAUAAGGAAAGUGGUUAAUGCACUUGAAAUGUAUAUUUUGACACAUCUUUUGAGAAAAUAUCCAAACUUCAGUUUAUGCACUGUUAACUGGAGUGAAAUGAUAAGGGAUGGCUUUUGUCUAUGAAUACUUUAAAUACUUAAGGGUAAAAGGUGGGAAGAUGGAUAAAAUUAGAAAUGUGUCAACUUUUAUUUAGUUCAUUAACAUGUUUUAGCUUCAGUAUUUGAAAUUAAUUUUCAUCUUUCUUAGAUUCUGGUCAAGCUUAAAAAAUGUAACACAAGGCUACUCAAAACUUUUUUCACAUUUAACAAUUAAACACUUUAUGUAUGUAUUCUUAACUAAAGCAAACUAUUUUUCAUUCAGCUAUUUUAUUUUUAAAAUGAAAGUCUCAGUCUUAAAGCUAAGAUCCCAGUGAGUUUCAAAUUUUCUGACAAUGAUAUUUUAACCAAACCUGACAUUAUAGUUUCUUUAAUUAAAAAACUGAAUGAUGGGGCAAAACUACAAAGCACAAAUAUGAUUAAAGUUAAAUUUCUCUCAUUUAAACAAUCUUGUCUUAUGGCAAUAUGUCAUCUGCUAAAAUUCAUCUCUGCUUCUGCAAGAUACAUUGCACGAUGCAGAUUUUUGCCUUAAAUAAAAGUCCCAUUACUAGCAAAUAAAGUCCUAAACAAUACUUACAAAAUGUAGAAUAUAAACAGGAAGACAAUAUAAAAAUUACUCACAGAAUAUCGACAUCGUUCUACCCAAUCUUAAAUGCCUUGUACCACCUGUUGCAAAUGCUGCCUAUGAGAGUUCACGUAUGGAAUUAUUCUACUGGACCCUGCAAGGCUCAGGAGAGUGCUUGACAGCUCCCAGAAUGAGACAAUGACCUAGCCAGAACAUUAAGGAGACUACACCCGUCCUUCAGACUCCAAAGGGAAAGCUAGGACGGCAGCAGAGUCAUCCUAAGGUGAGGCACUCCAGGAUAACAUUUUCAAUAUUUUUCCUUAAAACAUAAAGUUAACACCUUUUUUGUUAAACAUUUUUUACUCAAUUUUCAAAAAAAAUGCUUGAAAGAAUGUUUUGUAUGUAUUUUAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications