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Homo sapiens (human) LRIG2 divergent transcript (LRIG2-DT) URS000075EFE7_9606

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LRIG2-DT: LRIG2-DT is a non-coding divergent transcript that shares a bidirectional promoter region with LRIG2 [PMC7697779]. In the NABEC cohort, RNA-seq data for LRIG2 and CpG methylation data were available for 118 samples, while LRIG2-DT expression data were available for 119 samples [PMC7697779]. SVA_LRIG2, located 2 kb upstream of the promoter region of both transcripts and within the first intron of LRIG2-DT, may differently affect LRIG2 and LRIG2-DT at the post-transcriptional level [PMC7697779]. The Ensembl accession numbers for LRIG2 and LRIG2-DT are ENSG00000198799.12 and ENSG00000238198.2, respectively [PMC7697779]. In SVA_LRIG2 +/− individuals, median expression of LRIG2-DT was 0.451 standard deviations lower compared to genotype −/− individuals [PMC7697779]. A negative correlation was observed between increased SVA_LRIG2 allele dosage and transcription of both LRIG-1 and the divergent transcript in linear regression models, but it did not reach statistical significance [PMC7697779]. Methylation at cg23932873 showed a weak yet significant inverse correlation with LRIG-1 expression but no correlation with LRID-1 DT expression [PMC7697779]. The SVA_LRID-1 RIP genotype was not significantly associated with expression of either transcript but showed a negative trend between allele dosage and expression in both cases [PMC7697779]. Increased methylation resulting from SVA_LRID-1 may contribute to transcriptional repression at the locus, leading to modest modulation of both transcripts' expression levels observed in this study [PMC7697779].

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Gene Ontology annotations

Sequence

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GGGCCAGACGCAGCCGAGUAUCUUGAGGAGAAGGACUUUAAAGCGUUCAGGGAUUUUAGCUGCCGCUGUGGAGUUCCGCCGCUGUUCUUCCGCUGGAGGGCGCAGUAGUUCCUUAAGAGGGAAUGGUGCGGCGAAUAGCUGUGAGUUCAAAGUCCUGACUACAGAGUUUUGCUCUUGUUGCCCAGGCUGGAGUGCAAUGGCGCGAUCUCGGCUCACCGCAACCUCUGCUUCCCAGGUUCAAGCGAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGGAUUACAGGCAUGUGCCACCAAGCCCAGACAGAAUCUUGCCCUAUCACCCAGGCUGUAGUGCCGUGGUAUAAUCUUGGCUCGCCGCAACCUCCGCCUCCUGGGUUCAAGCCAUUCUCCUGCUUCAGCCUCCUGAGUAGCUGUGACUACAGGCGUGCACCACCACACCUGGCUAAUUUUUGUAUUUUUAGUAGAGACGGGGUUUCACCAUAUUGGCCAGGCUGGUCUUGAACUCCUGACCUCAAGUGAUUCACCCGCCUGGGCCUUCCAAAGUGCUGGGAUUACAGGCAUGAGCCACUGUGCCCGACCAUAACUCUAACAUUUUAUCAUCAAGAAAUGCUUGCUAUAUGUAUACAUACAUUAGAUUCACAGCCUGCAUAAGAGUUUGUGUGAUUUCUUACUUAGUAAAUACUGAGUGGUAAGGACAAUUCCAAAUUCAUCCCAUGAAAGUUAAUAGGGAAUUCCUAGCAGGUCAUAGGUCAGAUAGAAAAUCUGUCCUUCAUGAAACGCUGAGGACGUGCAAUUCCAAUUAAACCCACUCAAUCUGGAGAAAGAAAUCAAAGGGAGGGGGUGGGCCUGGAAAGAGUACAUCUUAUCUUCAGGUACUGUUUGUUUGAUUUUUUUUAAUACUUGGGGUUUGUUUCUGGGAAGAAUUCUUGACCUGGCAAAAAUUCAUAGUAAUUACUCAGGGGAAAGGAAAAAGAAGAAACAAACAAACAAAAAAUACAUUAAUGUGGUUGGAAAAAAAAUCUAAGAACAUGGUGUUGGUGGGAGAGAAGACUAAAUGUUUGUGGAAGACCCACCCAAGUGCUUUUGAUGUUUGACCAGUUAUUAUCUUAUUGUUCUUCCUGCUAUAGAUACAGCUGCAAUUUAUGUAACAGGAUGUUUAAAAAGAUUAAAGAGAAUCUGUAGUAGGGUUCUGAGAUGAUAAGAGUCCCUAGAAUAUGCAUUUAUGGACGUUUAGAAUAUAAGUUCCUGUACAUUCUUAGAAUAAACCAUCUAUUUGUUUCCUUUUUUAAAAAAGAAACAAACAAAAUUUGUAUUUCAGUAUGGCUGCUUCCUUCCAGCAAGUGAUAUGGAAUAACAGGCAAAGACAGCAAACCAAUAACAGAGCAAAGACAAGUUGGUGCUGGUUCAAACUGUGGCCCAUGCCGGUUCUUAAUUAGCUUUGAGCUUUGAGUCUAAAAUGUUUUAACUCUACAUUAUACACGUGUUUGGAAUUUAUUUGGAUUCAACCUGUUCAUCAGAAAAUGGGUUAUUCUAUGAUACAAGCAGGAUCAUUGUGUGAAAUUUAUGACUGCAAUCACCCAACGUGAAGAUGAAAGUUUAAACAUUUUUUUGCUAGAGGAGUUUUCAAAAAAAAAAAAAAAAAGUGUUCUAUAGAUGUCCCAAACAUACAGAGUGACUUACUGGCGUUUAAGUCUUUCUGCCAUGUGGAGUGCUAUCUUAAGUGAUAAAUUGGCACUGGGCACUUGAUAAAAGGUCAUUGGGCAUAUUCUCCAAGUUUCUGGUGUUAGUCAUGAAUUAAUUGCUUGUUAACUUUAAUUCUCCUAGCAACCUAGGCUAAUACCUACUGCACACUUGCUCUCUCUCUCUCACUGUAUUUCUGUGCAUGUGUAUGUGCAUAAUUUUUUUCUGAACUUGUUUCUGUUUGAUAAUAACUUACAGACAUGAUGCCCCUUUCCAUUAAGCACUUCAGUGGAUAUUUUCUUUUCUUUGUUUUUUUUUUUUUUUUUGAGACAGAGUUUUGCUCUGUCACCCAGGCUGGAGUGCAGUGGCGUGAUCUCAACUCACUGCAACCUCUGCCUCCUGGAUUCCAGCUAUUCUCCUGCCUCAGCCUCCAGGUAGCUGGGACUACAUGCAUAUGCCACCAUGCCCAGCUAAUUUUGUAUUUUUAGUAGAGACAGGGUUUCACCAUGUUGGCCAGGCUGGUCUCAAACUCCUGACCUCGUGAUCUGCCCGCCUCGGCCUCCCAAAGUGCUGGGAUUACAGGAGUGAGCCACCACGCCCCGCCAGUGUAUAUUUUCUAAAAACAAGGAUAUUCUCUUUCAUAACCACAAUUAUAAAAAUUAAGAAAUCAAUAUUGAUUCAAUAAUAUUUUCUAACCUACAGACCUCAUUUGAAUUUGCUCAAAUGUUCCAAUAAUGUCCAUUAUGGUAAAAUAAAUUCUAUAUCAUACAUUG

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