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Homo sapiens (human) NPTN intronic transcript 1 (NPTN-IT1) URS000075EF67_9606

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NPTN-IT1: NPTN-IT1 is a long non-coding RNA (lncRNA) that has been studied in various types of cancer, including prostate cancer, bladder cancer, breast cancer, colorectal cancer, hepatocellular carcinoma, lung adenocarcinoma, nasopharyngeal carcinoma, cervical cancer, and osteosarcoma [PMC9690797] [PMC8289330] [PMC9895102] [PMC10160629] [PMC9360822] [PMC8534192]. In prostate cancer specifically, NPTN-IT1 has not been found to be related to the disease [PMC9690797]. In breast and colorectal cancers, NPTN-IT1 is predicted to be a possible biomarker and its association with the diseases needs to be validated through wet experiments [PMC9895102]. In bladder cancer, NPTN-IT1 has been reported to associate with the disease by attenuating the expression of miR-145 and ILF3 in bladder cancer cells [PMC9895102]. Furthermore, NPTN-IT1 has a low expression level in tumor tissues and can inhibit the growth and metastasis of hepatocellular carcinoma, lung adenocarcinoma , nasopharyngeal carcinoma and cervical cancer cells [PMC10160629]. Additionally, NPTN-IT1 is one of six lncRNAs that have been identified as independent markers for assessing the prognosis of patients with osteosarcoma (OS) [PMC9360822]. Finally, in KGN cells (a human granulosa-like tumor cell line), NPTN-IT1 is downregulated and its overexpression inhibits cell viability and migration while promoting apoptosis [PMC8534192].

Genome locations

Gene Ontology annotations

Sequence

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CUCACAGACAAAGGAGAGUCUGAUGUAUCCACCCAUCUAGUGUAAGACAGAGAUAGCAAAGGCGGAACAAAUGGAGUCCAUGCCCCGAGGCUGUGCCCUCAAGCUGGCCUAGGGUCAGAGAAGGGAGGAGAUGGUAGCAGCAGAACCACAGCACACCACUGAGCACUGGAAAGAGCAAGAGCUGAAAUCUUAGGUUAUUGGAUAUGCCUAGAGUCAGAAAAGCCUUGGGAAAUUUUUGGUGAUCGAUUUUUCCUGUGAAGGGGGAAGCUGCUGAUGGAGACUUGUAUCUGCAGUACUUCAGGUUCCCAGCUGGCUCCCCAUCCCCACCCUAUAACAUGACCGGCGUACAGAAAUUAAUUGGCCGACUGUUACCACCACUAGUCUGUCCCUGGCUAGACUAGACAGAUGGGUGUGCCCCUGGGCUCAGUGGUAGCCUACCCGGGGUGAUGGUGGGGUUGCCAGCUGUAGUCCAGCUGUUCUGGGGCCUGUGUUUGUGCACCUGUGGUGCUGUAUCCUGCCCCACAGAGCUGGCUGUCCAGUGGAGAAUACAAAGUGACAUCUGGUGCUCCCUCAGAAAGAAUGUGGCCCCAGAGGCAUGCCAGUGGCUUUAGACUCUCUGGGAGGACAUGUUUGAGAGCAACAGCCCCUUCCCCAUCUUUUCCUUUCUUCUCAGCAGUUAUAAAUCUCUCUGCCUGCAGUAAGUAGAGUGAGUGGCUGGUGAGGAGGUUUGUUGAUGACACUGACAAUAUCUGGUGACUCCCUCCAGAUGUGCACUCAGCAGUGAGCUGGGCAGAGGCGUGGGAAGGACGUUGGCUGGGAGCAGACGGCCUCUGCAAAUGAAUCUCUAGUUUCCUGCAACCUGGGAGUGUCCCCAUGAGUUUUACUUUCCUACUUUAUGAAGUGAACCUGCUUUCUUUGGGAUUUCAUGUACUCCUAAUGCUUUUUCUCUCCAGGUAUUUCUUUCCUGCUACAUAUUAGGACUCCCAAGGCAAGAGUGCACCUUUAUUUAGACCUGGGAGUAAAGGGAAAGAGUUGCCUGUCUUUCGUGUGUUUUCAGCUUUGGCUCUGUGGGAUCAGUUAUGCCUCAUUCCUGAAAAGGGCCUUUUUAUCCCCCCAGAAUGCUUUUGCUUUGCCAAUACCACCUUCCUCAGCCUGCCUUUUGGAAAGGUUGAGAAGCUAAAAAGUCAGGUAAGAGAAGGCAGAGAUGGACUUCAGAACCUGAUUUUUAAAUUUUAAGGCAAGGCUGGCUGCCACUGGUGAGAGUGAUGCAGCAGCCUAGCGUGUUCCCAGCAGAGGUCUAGUCUUUGCCCUAAGAAGUCACCGCGCUUAUGAGGUUGCUAUCACAGUGCAUGUGGUAGGUUAGAUUUGAGAAAUGGUUAGGAUUGUUCUGUUGGAUAAGUGCAGACACCUGCCCAGGGAAGCAGCUCUUUUUUUGUAAGAGUUUUCUUGGUUACUGAAAUCAAAUGGGGGACCAGUUUGUUAUAGGAGACAUCUGUGGCCAGCAAAUCUGAACAGCUUCCUAGAGGGAAAGUACCUCUUUUAAACUAAGUUAUUAUAGACAGUGAAUGAAUCCUACCCUUAAAAGAGAUGACGGCAGGGUAAGUGCAAAGUAAAACCUCCUUGCUCUAGUCUCUUGGGAGAGUAUUGUAAUGAAAGCAGCGUUUACUUCGUUGUUGUUGCAUUGGGGUGAAAAAUCUGAGAUGCUGGAAUGAUGGCAAUGUUUGCCUUCUCUCCUUCCCUUCCUGACAGCCAGUGUGGGCCAGGCUCCACUCUCCAUCUUCACACCCUGCCCUUGCUCCAGUAUUUCCAUUCUGUUUUUCUCCUCUGUCUCUUUCUGUCUUUCUCUCAAACUCCAUCCUGCUUCCACCCCUGCCCGCUUUUCUUCUCCUUUCCUGGAAGUAAUCAUUAAACAAAAGAAAAAGUUGAAUGUUCUUUGGUGAGUUUCCUUCUUCUCUGCCUUUUCCUUCUUUAGCCAGUUCCCCUCAACCCCUGUGCACUCCAUAGGAAGGACAAACUUACCUGUCUGCUUCCUUCCCAUGUGCUUCUCCCCAAAUUUUCAUAUAGAUAUAUACGUACACUCCUUUUGGAAUAAACGAAGAGGUACAUUAUAUUUGACACAAACUUGGGAGUGUUAAGAGGUCAUAAGUGUUUACCUAUCAGAUAACCAUCUGUGGCUCUGUGUUGGAUUUUUUUUAUACCAUUAGGAAAAUGGGAAUUUUUUUAUAGGCCUGCCAUACUUCUACUUUGCCAAAUAGCACUUUAUUAUCAAGAUACACCCAUGGCUCAUUUCAGACUCACUGAACUUUUUUUAUAUGAAUGCACAGUCGUCAUAUUUUGGGCAGUCUGUGAGUUCUUGGUAACUCAUCCCCUUACUACAAAAGCACUAAGUGAACAAUACAAAAGUAUAAAAGCACAAAUUUGAACUUACAUAGUUUAGUUUAAGUAUGUUUCACUAGAAAAUCAAAUAUUUAGAUUUCUCACAUUGAAAAUGCUUAGGAUUGAGGUUUAGCUGCUUCCUUUAAAAAAAAAAAAAAAAAAAAAGCCCCAUGUCUUUUUUCUUUACCUACUGGAGUAUUCUCAGACCAUUUCCUACAUGAAAACACCCA

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Publications