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Homo sapiens (human) long intergenic non-protein coding RNA 954 (LINC00954) URS000075EEFA_9606

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LINC00954: LINC00954 is a long non-coding RNA (lncRNA) that has been identified as a potentially risk lncRNA associated with septic shock [PMC7725549]. It is one of thirteen lncRNAs, including PAXIP1-AS1, RARA-AS1, TSPOAP1-AS1, CHRM3-AS2, LINC01215, THAP9-AS1, TRG-AS1, MIR646HG, NFE4, A2M-AS1, CARD8-AS1 and MIAT that have been implicated in septic shock [PMC7725549]. These thirteen lncRNAs have shown significant differences in expression between the case and control groups [PMC7725549]. LINC00954 has also been found to be differentially expressed in the regulation of HMGB1 expression in nasopharynx cells [PMC8173225]. Furthermore, LINC00954 contains a zona pellucida domain and is one of three gamete interacting proteins associated with oocyte fertilization along with ZP1 and MFGE8 [PMC6839265]. Although little is known about the involvement of MFGE8 and LINC00954 in fertilization specifically, their high expression levels and possession of zona pellucida domains suggest their potential role in this process [PMC6839265]. In addition to its involvement in septic shock and oocyte fertilization processes, LINC00954 has also been found to form dysregulated ceRNAs with miR-185-5p and lncRNA DLEU1 in gestational diabetes mellitus (GDM) [PMC6317690]. Overall, these findings highlight the potential significance of LINC00954 as a key lncRNA involved in various biological processes.

Genome locations

Gene Ontology annotations

Sequence

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GUGCCCAACCCGCCCGCUUCUCCUGCCUAGGCUCUUCUUUCUGCUCCUGUCGCCAUGGCCCCGGCCUCGGCGCUCAAGCGACCCUCUCGCUCCGCCCAGACCCCUGGAUGCCCAGCUGCCGCACCUCCCGUGGCCCCACGCUGUGGCUACGUGUUGUCUGAAGACGCCUGGGGAAACCUUCAGGGCCUCUGUACUGGCCUGUCAUGUGGUCAACCAGGAUAAUAGAUGGUUUUCCCUCAGUGUGAACAUCGAGGUGUCUGGGUUCAUGGAAGCUGGUGAAGAAACCACCUACAACUAUACCAUGUCCUGUCCCUAUUUCACAUGGGCCUCGAGGAAGAUUCUCUGAAGGGAACUACAUGGAGAUCUCCUUGAUUGCACGGUCAACCCCGCUCCUGUCUGUCAGGCUCAGGAACCACUUACAAGCUAUGGCAGGUGAUGUUCCAGCAUCCCACAGGGAGGAUUAUGCUGGUGAGCCACAUGGCCAAGCAGGACUAUGGCUUCAACAGCUCUGGGGCCUGCAUGUUCCUGCAUUAGCCCUACUCCAGCAAUGAGGCUGAAGUUACCAGAGUGACAUCAUGGUAUCUGGUGCAAGCUAUAGCAUCCACCUAUUCUUGGAGCACACGUGGUCAGACACUGAUUGGCAUGUGACCAAGUUGAUGGUGGUCAAAACAGAACUCCUUUCAUGCCCACAAGCUUCAGUAUUACUAUGUUCCCUGCCACUUCCGUUGAAGUUUUGCAGGAUUGGGAUGAUCCUUUGGUGUGAACGAAGCCCCAAAGAGGACCACGUGGAGAGUGCCUGACUGUUCCUGUGAUGUCUUCUAGUACAUGAACAGGAAUGAAACCCACUAUGUCCUCCAUGUGAACUACAUGCUGAGCGUGGGUCCAGAUGGGAAACCAUUCUCCUACCCUGCAGAAAUGGUAUAUAGUUUCAAGGAUGUGGACCUCACUGGUGAGAAGCUGGGCUUCUGGGUCCCCAUGCUGCUUCAUCCCACCUCCCAACCCUGUCUUCAGGCCCACUGCUGAUCCCAGUCUAGAACCACAGCACCGCCCCCAUCCUGCAUGAAGAAGGCCUUGUGCAUCUGCCUUGGUGAGAUCUUUCCAGGCUGACUGGUCUGUACUCCCUGGGGAGAUGAUCGAGACCAGCUCACACUGCUGUGUGUCACAUCCAUACCUUCUAUGGGAAAACUAACCCCCCUCGCCUCCUAUGUGAAGUCUCAGGCUUCACAGCCCAUUUCAAAUGCUGUUUCUCCUAUAACCACAUAGCCUGCCAACCACUGGAUCUCCUUUCUGGUUCCUCCCUCUCCCCCCAACUUUUUCCUUUUGAACUCUCAUAAUCAGAGCCAUAACCAUUUUCUGCCUUGCACUAGUUACUUGUCCUUGACUGUCUUUAUUUUCCCUUCUGAGCUGACUUUCUUGAAGGCAGGGCCCCCAACCUGAUCACCAUGCCUCAGAUAGUAUCCAGGUUUUGCCUUCAGCCCCUCAAAUAAUACAUAUAAAAAUGAACAAAUUCCAAUAUUUAUCCACAACCUACUUGAUGGCCUAAAAAUGCAUUUUAAAUGGGUGUGUCUGAGGUAACUUGUGAAAAGCCCUGGGGUCAGGAGCCAAGUCCUACCUCAAGGAGCAGCAUAAAGGCUUAGCCCAGCCUCGUCCAAGGACUGCCAGGUAAAAUAGAGAACAGACUUUGAUCAAAAUAUGGUUGGAAACAGGAUGGUUGUGAGAACUAUGGUUGUGUUCCUAGUGUGUUUCCCUAGUGGGACUGUGGCCAUCUCUUCCAUGAUGGCCACAGACCCUUCCAUUGACAUGUGCAAGGCCACACUGAAGGAUUGCACCUGCAAGCCAACAGAGUCUAGCAGCAACCAAACCUUCUUCUGACUUGACGUCACCAGCCGUGGUACCUCAGUGAGGCUGCAAAAAAGAGAAUAACCUGCUAGAGGUAGACUUUUACCCUGUCUCCCAGGGUGAGAAGGUCCAAUACCCCUCAUUGGUCAAGAAGCUGGUGAAGUUUGUGGCACCCAGAUUCAAAGAGGUGUAUCUGUACCACCUGACCCAAUCCUGCCUACACUUGGACCCUGACGGGCAUUGUGGUGGCCAGUACUAUCCAGAGGAGAGAGAAGGAGUGACUCCAGGACUUAUAUGCCCACAAGCCAAAAGAAGAUCAAGAUCUGAGUGGGAACUGUGGAAAGCAUGUCAUGCGAGCCCCUGCCGCCCUUGAAACUCUGCGUUCCUCCUCCUCAAAGAACAGUGCCUGAAGGUCCUGGCUGUGGCCCUGGCUGGCCAUCUUGCUUCCUGGUCACGGUGGUGGCCACUGUGCUGGUCCUGUCCAAGAUGACCUGUACAUCAUUCCAUGAAUGACACGUGACAACAGCUUCCCAGUGUAAUAAGCACAUUUAACCCAGCACUUGUCAGCCCCACUGUUCUGUUGGAAGUGUUCUAUCUCACUGAUCUUGCCUCUCCUAAAGCAAGGGACAACUCCUGGCACUCCGCUGCAGAGGCCCUUGAAGCCUGUUGGAAUUUUAGUGAAAUGAGAUGCCUGGCUUAAGCCAUGUUGCCUGGCUUCUCAAGUACCAGCGGACAUAUUACUAGCAAGGAAGAAGGCUAGCAGCAAGAAUGGUUAUUGCAUCCUAGAGGCAUUUAGUGGAGGAGAAAACUGCCCUGGUACCGCCAUAGCCCUAAGUGCUGCCCAGAGUUCUGAGCUCUCGAUGAGCACUUGGAACACGUCUGCCUGCAGCCUCCCUACACUUUUUUAUGACUUGUCCUACUUGUCAAGCCCAGCUUGUCCCACUUCUCCACAUGAGUCUUCCAGUGACAUCUUUGUGACCAUCUCCACCCCCUGGGUAAAUGCUCCACGCUGGGAGUCCACAAAACACAGUCUGACUUAGAGAUUCUCUGGCAUGACUCUCUUCCCCACUGUGUACACUGACUGCCUUAGAUGUAGGCCUCUUGUUUGGGGCCCUUCCUGGCCAGACCCUGAAGCAGCCUCUGAGGAGGGUGGUAAGAAUGGUUCCCUAGAGCCCAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications