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Homo sapiens (human) non-coding repressor of NFAT (NRON) URS000075EE86_9606

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NRON: NRON is a long noncoding RNA (lncRNA) that has been implicated in various biological processes and diseases. It has been suggested that NRON could be a potential target for regulating osteoclast activity [PMC7210890]. In patients with heart failure (HF), NRON and another lncRNA called MHRT are upregulated in the plasma and are correlated with the presence of other cardiac biomarkers [PMC6884711]. However, stimulation with IL-17A inhibits NRON levels [PMC5846253]. NRON has been shown to attenuate atrial fibrosis by promoting NFATc3 phosphorylation [PMC7052857]. In atherosclerotic aorta, the expression of NRON is decreased compared to normal aorta, while there is no change in its expression in the myocardium [PMC8919297]. Knockdown of NRON affects the interactions between Tat and CUL4B or PSMD11 proteins [PMC4909936]. The decrease in NRON expression may have value in predicting the time to viral rebound in HIV-1 infection [PMC9866393]. PSMD11 is a key component of the NRON complex and its knockdown affects the circadian clock of cells [PMC10038281]. Furthermore, NRON represses HIV-1 transcription by inducing Tat protein degradation and plays a role in maintaining viral latency [PMC6451131]. It has also been suggested that NRON may have potential tumor suppressive functions due to its repression of NFAT activity involved in tumorigenesis, cell proliferation, migration, invasion, and drug resistance [PMC4586798].

Genome locations

Gene Ontology annotations

Sequence

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CACAUCUCUAAUGUAAACAACCCAGCAAGGGAAGUAGUACCCUAUAUGUGGGGGAAAAGUGGUUCAGAGAGGUUAAGUAACUCACCCAAAGUCACACAGCUGAAGAAAAUGGCUGGGCUAGGAUGUGCGUUCAUGCUCUUUCCACCAUGCCAUGUUGCUUUACUGAGAUGACACAGGGCACAAAGUAAGUGCAAACACAGACCUGUUCAUUUUCCAUUCAGGAAGCCCAUUUGCCACGACCAAUGCAACUCCAACCUACCAGGCUGACUGUAGAAUGGGUUUUCCUCAUGGGCAACACAUACACACAUGCAUGCAUGCGCGUGCAUGCGUGCACACACACACACACACACACACACACACACAAAACCAAAUCACUGUGCAUUGGACAAGGGGAAAAAAAAGCUGCCACUGGAAGAUGAAGGAAAUCACAAUUCCAAACUCCCCAAGUUCCUAAAUGCAUAAAGUACGUGCAGCUUGACGGCAUAUGGCAAAUCAAUUACUAGUUUAAAUCUUAAAACAAAAACAUGGCAAGUGUGGUGCAGAAAUAAUCAAGAACAACGGUUAGGUUUAGAUUACAGUGGGCCACUAGAGUUUUGAAUACAAUUAAUCAUCAUUCCAGGCAAUGGGAAGCCAUAUUGACACUUAUUCCUAAUUUGAAUAUUUAAUUAGGGUGAAGUUCUUCAUCAAAUUAUCGCAGAACUGGGAGAAAGCCUGGAAGACUUACACAAUUACUAUCUUAACCCCUUCCCAGCUGCUCACCUGUGAACACAGCCAUUCUAGUCCCAGCUCCGCAGGGGAGGUUGCCUGUGCCCAGUCUCUGAUGCUGUGGGGUGCUGGAGGGGUGCUGGUGACUGGAGUUGCAACUGCAGCAGGCGGGAGCCACGUGGUGGCAAAGGAAAGGUCUAAGGGGAUGCCCUGCUCAUGCUUAGGCUAAGUUCUGCAUUGAACCCUGGACACAGACAGAAAGCCAGCAUGCAUGGGUGCUCACUGGGCACCAGGGUGGUGCUUUCUGUGUCCCCCCCCAAUUUAAUUCUCAUGACAAAUCCUGCAAAGGAGGCAUUUCUAUCCCCAUUUCACAGAGGAAGAAACAGGCUCAGAGAGUGAUAAAACUCACUCAAAGUAACACCGCCUGUGAGUGGUGUAAAGAAGGCCCAAGGGACACACACACACACACACACACACACACACACACACACACACACACAGAGUUACUCACCAAAAGUGAUGACAAAGAGAACACGCAAAGGCCCACAAAAAUGUUUUCAAGGCUGUAUUUUGGAUCAUCUGCACCGUGUGGCUAAAUCAAAGGAAAACCAAAACCCAGGCCUCUUCAAUCAGCAUUCUAAAAUUUAACUCUUGGGUUCAAAAUGCAUUACUGAGCCCCCCCCCACAAUGGAAGUCACGAUGCCGUUGUGGCCAGGGGCUCAGCAGAAUGGUGGAGGUGGGGGCAGCAAAGCUCAAGGAACAGUCCCACAAGGCCGAUUUGAGGCAAGGUGACAAGGUGGCCAUCCAAACCCCGCAGAGUAGGACUCGAGAAGGUGGGCGCUGCGGGACAGGUGUCCUUGGGGAGGGGAAUGUUUGCAACAGGACAAAAAAAUGUGAACUCUUUCUUCUUUCAAGAUGGCCAAGGCUCAAUGAUAGCAUUUAGAACUAUACAUCAGCUUGGUGAUUACGUUCCUUAAUGUACGCCUUUGCUAUCUGAAAAGACUUUUACUAACAUUUCAUAGAUACUAUGUGAUUCUACGUGACCAAAAACAACACAUUUUGCCACAUAAUCUCCCCGAAGGACUCAGGACACGGCCAAGGGCUGAGUGCACACAUGGGACUGGACCACGGUAGGUCCAGAGACCUUUCUGCUUCCAGCCUCCACCGAGAAGCCGAAAAGGAGGGACAUCCUGAUAGUUUCAGGUUAGCCAUCUCUCCUUAAAAGCCUGUGACGGGUUCACUUACCCUCUUGUGGAAAAGGCUCCAUUUGCAGUGGCCACUUUCAGCAGGAAGUGGAUCGCCAGGCAGAAGGAGGGAGCCGCCCCAGCCCCCUGCCUGGGCCCACUGCAGGCACAGACCCCGGAUCCGGAUCCAUCAGGCCUGCGUGGGGGGAGCGAAUGGCAUCGGGAACUUUGAAACUUUCCUUUGUAUAUUACAUUAAUCCAUAUAAGAAAAUCUCUUUUAAUGAGGAGUGAUGUAGUUACAAACUCUCCAGAGCCAUAAUUAGAGCAAACUAAUUGAAGUUGUGUUUUGACACACUUUCCAAAUUCACGGGUGCCGGAUGACAUAUUCACAACACUGCUGCCGCACAACCAUGGCGACGGCAAAAUCAUUAGGCUAAUAACGCUUAUUUGCAUUCUUAUCAUGCCGGCAGCUCGCCCUUAAAUACUGUUUCCACUACUGCUCCUUUACUGUAAGUUUCCACCGAAAGAUAUUAACAGUAAUUAUUAGUACUUUAGUGGAAUUUUAAUGUUAAAGAAUAACAAUGUGCAUUAACAUACAUUGAAUGGCAAUUCUUUUUCUUAACCACCCAUCGGAAGGUUUGGGGGUUCUUCCUUGGCCCUCUCCCCAGAGCUCAAGGGUAACCAGAUGCGAUUUCAGCUUCAUUUACAAUUCAGGGUCCACACCCAGUGGGAUCUGAAGUCAGGUUUCUGAACCAUUCUGCUCCAAAAGUUUGAUGAGAAAAAUCUUUCUUUCUUUUUUUUAAGUACAAUAAAAUGAAAUAGUUAAGGAGAAAUUUUUUCC

Taxonomic tree

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Publications