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Homo sapiens (human) SOX9 antisense RNA 1 (SOX9-AS1) URS000075EE78_9606

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SOX9-AS1: SOX9-AS1 is a long non-coding RNA (lncRNA) that has been found to play a regulatory role in metastasis in hepatocellular carcinoma (HCC) [PMC7568413]. It has been shown that SOX9-AS1 is induced during mesenchymal stem cell (MSC) adipogenesis, but not to the same extent as chondrogenesis [PMC5769619]. In HCC, SOX9-AS1 targets miR-5590-3p to regulate the Wnt/β-catenin pathway, which is involved in cancer metastasis [PMC7568413]. This suggests that SOX9-AS1 may contribute to the metastatic potential of HCC by modulating this pathway. The specific mechanism by which SOX9-AS1 regulates miR-5590-3p and the Wnt/β-catenin pathway in HCC remains to be fully elucidated [PMC7568413]. However, this finding highlights the potential of targeting SOX9-AS1 as a therapeutic strategy for inhibiting HCC metastasis. Further research is needed to fully understand the role of SOX9-AS1 and its potential as a therapeutic target in HCC metastasis [PMC7568413].

Genome locations

Gene Ontology annotations

Sequence

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CUGGCCUGAGCUCCGGACUCCGGGGACAGCGCGUCCUGUCCCGAGGGCCUCCCGCCCCCCGGGAAGGCCAAGGUCAUGAGGUCAAACCCCAACUUUUGGGCUUCCGCGAGAGUAAAGCCCCCGGAUGGUCCUCGGAGCUGUGACGUCACAAAAAGUGCUUGGGGUCUGGUUUCCCGCAGAAUCCAGCCUCUGUCCACGUGAACUCUGCUCUGUCCUCUGGGCUCAUAAUGUUCUGAGACUCUUGCUGCCUCUUUCAUGGAUUCCCCUUCUAUUUCCCUGAGACGACUCACAGGUCACAGAAAGCUGCCUCCCAUCCUUGCGGCUCCAUCAAGGUGCUUUGGAGGCAGGUAAAGCGCAGCCAAAAACAAUCCAUUGAUACACUUGGUGACAUUAAUUGAGAAAAAAACAAUAUGGUCUGGCCAUGGAGGCAUGGUAUCCGUAACAUCCCCCAAAGGAGCUAAAGAAGAAAUCCACAAUUUACCAUGAGCAUUUCUCGUCUGAAGAUUGCCAAGCGAUUCCUCCAGGACAUUCCUCAAGAUCAAUUUCUGUUCAUCCACCUUGUCCUGGGAGGGACAUCAAUGGGUUUCCAUGUCCUUUGGCUUCUGGUUGAGUUCACUCAGUGGAGAACCCUGGCAAGAGGCAGGAAAAGGGGAGGAAGCAGCCUGACCGGUUUGAAUUUCACCUUCUGUUCACCUUGGAUGAGAGCAGUAAUCAUCACGAUCCCAGGGAACAGCCAAAGGAAGAGAAAAGGCAAAAGAUUUGGACAAGACUCAUGAAGACUAACAGCUCUUGGAUAAUUGAGAGAAGGCAGCUGCGUGAACAGUUUUGAUGCAAUCAUGAAGGCAGGGCCCAGUGCCUGUGGCAUCUGCCUUUUUCUGGAACCAAUCCAUAUUUCCUUGUGGUUUUCUAAGGUGCAGAGAGGGCACAUUGGGAACUUUGCUUGGGGUCUUUUUCACAUCUUAGAGGGAAGGUCCCUCAACAUCUGCAUUGGCGGAGUGUGAUCCUCAUGUCCCUCUGAAUGAUCUGGACUUGAGGUAACCAGCCCCUUCCAGGAAGCUGUCCCAUGAGUGAAGCCUCAGCAGCAGCCUCUGUCAGUCCCUCCCCCACAGAACCUUUGGCUUCCAUUUGACCAGCCUUGACAUCCAGUGUCCAAACACCGAUAAAAUUGAUUCCACUAAGCGUGGGAAAGUCCUGGAGCAUCGAUUGUUUCCUCCUCUGCACCCCCGAUACCCUGGCAUUAGCACUCUCCCAGAAUGUACCUUGCUUGUUUGAUUGGAGGAGGUCAAAGCCCUGAUGAAGAAUGAGUGGAAUUCCACAGGAUUGGAGCAGUCUUGAUAAAUGACAGCAGGGGAUGGUGUGGGGAGGGGAAAGGAUCAGAGGAAGUGUGGAUAAAUGAAUGGCUUAAAAAAUAAUCCACCUUUGCCUCCCCCUUUUCUACCAGUCUGUCUAGUGCUUCAGGGUGAAAAAAAAAAAAAAAAGCUUGCCUUUCUAAACAUUUGGAGUUUCAGAAAUGAUCUAUAGAGCAUGUUUAGUUUUUCAAGUUAAAAAUAUUAAAAGAAAAAAAAUGUUUGAGGGCUUUACUGCUUUCCCGCAAAGAGCUAGAGCCACCCAAGCAGGAUUGACUGUCAUUGGUUUGAGGUUUCUGUUUGCUUUGAGGCUAUUUUUUCCUUAGUGCUAUAAACUAGAUCAGUCCAUUUUUAGCUGAUAACCCUUUCCAAUUUCGCUGUGAAAUGAGGGGCUGGUUGGGUGGUUUUUUUUUAUGUUCUUUCCAGCGUUGACUUUUAUGGUCUUUGAUUCCAAGGUACCUCGUCGACUCUGAAGACGAGAGAUGGGUAGGUUCUAACUCCAGAUGAGCCACUGCAAGAUGGUACCAGGAUGAGAUAGAGAGUCUCUGUACUAUCUUUUAUAUGUUCUCAAACCCAGCCAGGGAUCAGAGUGACAAUAUAACAUGGGGAAUCAUAGAGAUGUUUAUGGUAAUUCUGCUAUGAGUCAACUGAGAUGUCCCUUAUGGAGAUAACUUCCCAUACUAUAGGCAGUUGGACAAAGAUGUAAAUGCCUUGUUUACAAAUGCUACCCAGAUCUCCUAAUUAGGACCACACAUGCGGAGAACCCAACAGCUUUUGGACUUAUCGGCCAAUGGUCUUCUUGGGAAGGUCUCUCCUAGUCAUGGGAAUUGUCUUUUUAUUGUUCAAGCUUUUGCAUAGACCUGGAAGAGGCAUCCAUUGCUGUUACCCCUGAGUUUAUAAUCAUGCUGCAAGUCCAGUGGGGAACUUUGGCACAAAGCAUUGAAUGAGAUGGGACUGCACUUAUGUAGCCUGCAUUUCUUGAGAAUAAAGAUUUCUGUUCAUUUAGUGCAGUGGUUAUCAUCUGGGGGAAAACCAGUGAGUAGAGGCCAGGGAUGCCACUAAAAUCCCUACACUGUGCAGGAAAGCUGUCAGCCCUUUGUCCCACAAGAGAUUAACUGGUUCCAAAAGUCAGUAGUGCUGUGGUUGAGAAACCCUGUUUACCACCUGUAGGUUCCAGAGAGCUCGGAUGGUGGUGGUCAUUGUGCUAAGUUUCAAAUUCAGUAUUUAGGUUUGGUUUUUAGCUUAUAGGCAACAAAUUGGCUGACUAUGGGGUGAAAAGGAAGCACCUCCUUUAUCAAGAUUGGCUUCAAAAGAUGUCUGCCUCCCCUUCUGGUGGGUCCUGUGUCCAUUCACAGUGUGAGAAAUGGAAAGGAGGUCACUAAGAGACUUGCAAUGGAUGUAAUAACUGGAUGCAGAAACUCUGGAUCUGAAGGGAAUGUUCAUGACUAUUUCAUCCCUCCUGCUGCCUUGGAGAACCAAACGCAGGAGCCACCCAAGGUGAAAACCAUCCAUUUCUUGGAGAAGUGCCACGGUGGGGUUGCAAGUCCCAGGAUCAAGUUUUCGAUGUGUCUCUUUUUCCCGUAAAGUGGCUGAAAUCUGAAGCUGAAUCUGCAAGUGUCAUGGAGUCAUUGAAUCUCACAGUCUCAACUGAUAAAAGUUAUUAAAGGUCGUCUGGUUCAGCCUUCUA

Taxonomic tree

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Publications