v24

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Homo sapiens (human) KANSL1 antisense RNA 1 (KANSL1-AS1) URS000075ED2D_9606

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KANSL1-AS1: KANSL1-AS1 is a long non-coding RNA (lncRNA) that has been identified in various studies and is associated with different diseases and traits. It has been found to be a target regulatory gene in risky behaviors, along with other genes such as PLEKHM1, MAPT, APBB2, and TFEC [PMC7066886]. KANSL1-AS1 is located on chromosome 17q21 and has been implicated in regulating cardiac rhythm in zebrafish models [PMC8762216]. It is also involved in ovarian epithelial tumors and Parkinson's disease [PMC9825460]. Allele-specific changes in expression have been observed not only on KANSL1-AS1 but also on other genes such as MAPT-AS1, CRHR1, LRRC37A2, MAPK8IP1P1, and MAPK8IP1P2 [PMC7099620]. The expression differences of KANSL1-AS1 may be due to nucleotide changes in its promoter region that are highly conserved across vertebrates [PMC9189494]. KANSL1-AS1 has also been associated with primary open-angle glaucoma (POAG) [PMC9903700]. It is one of the major eGenes for retinal ganglion cells (RGCs) and shows significant expression differences after Bonferroni correction [PMC9903700]. Additionally, KANSL-ASL has been identified as a candidate gene for anxiety disorders and its abnormal expression may be associated with the progression of osteosarcoma [PMC8505959] [PMC9360822].

Genome locations

Gene Ontology annotations

Sequence

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GCCAGGAGGCGCGGCCGCCGCCGCCUCAGUCAUGGCUCCUCGCCGUGGCCGAUGUUUUUGUACCUCCAUCUGCGGAGGCCGCGGCGCCCGGCCCCAGCUGCCCCGGACGUGCGGCGACGGCACGCAGCACUGCGGCAGGGGGAAGCCAGCCCUCGCUGCGGCCGAGGAAUGGCCAUGAGAUGUGAGUAGAAGCCCCCUGGACAGCCUCCAAAAGAGAACUGUGAGAAAAGGUUCUUCAAUCCUAAAAAUGAUGGAGGAAAAAACAGUCCCUCUUCCUCAGACAGUGACACCUCAAACUGCUACAGUCACCUUUGCAGCAAGCCUGAAGAUGCCACCAACAUCAAAGGGAAUAGAGAGUUGGUCCUUGGUGAUAGCAUUAAGCCACUGUAUCAACCAAUCCUGACAAUUUGUAUGACUUCUGGAUUUCCAGCCACAUUACAACAAUGUAACAAUAAACAUUUAUUAAUUGCUUAAGCCAAUUUGAGUUAGGUUCCUUAUAUAAUAAAUGAAGUCAAAAAACAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications