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Homo sapiens (human) downregulated RNA in cancer, inhibitor of cell invasion and migration (DRAIC) URS000075EB40_9606

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DRAIC: DRAIC is a long non-coding RNA (lncRNA) that regulates NFRKB and UCHL5 at the protein level [PMC7183705]. Higher levels of DRAIC have been shown to prevent invasion and migration of prostate cancer (PCa) by modulating androgen receptor (AR) and FOXA1 expression, leading to longer disease-free survival [PMC5043609]. DRAIC also plays a role in inhibiting the progression of gastric cancer [Zhang Z. et al., 2020]. In addition, DRAIC facilitates the proliferation and migration of nasopharyngeal carcinoma cells and regulates autophagic flux [PMC8215581]. It has been observed that DRAIC represses cell proliferation, migration, invasion, in vivo tumor growth, and induces cell autophagy in certain cell lines [PMC9386314]. The expression of DRAIC is higher in ER, PR, and HER2 positive patients compared to their negative counterparts in breast cancer samples [PMC6315495]. Furthermore, DRAIC has been found to bind to miR-34a-5p and negatively regulate its expression [PMC8383934]. Similar to DRAIC, lncRNA PCAT29 also acts as a tumor suppressor by modulating AR expression [PMC5043609]. References: - PMC7183705 - PMC5043609 - Zhang Z. et al., 2020 - PMC8215581 - PMC9386314 - PMC6315495 - PMC8383934

Genome locations

Gene Ontology annotations

Sequence

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CAGGGAGCUGGUUCCAGGAAAGAAGGGCACAUGAGCAAACAUGAUGGCCCCUUUAUGAGAGGUAAUUUACUGAAAUGCACAGCGAUUACCUGCUCACCCAGCCCUGAUGUAAUUAAAAAUGGCAGGCUAGGGGCUCUGUUUCCCCCGGCUCUGGCAGAGAAACCUGGGUUUCGACUUGUGAAGCUUGAGGUUGGAUGUGGGAAUUGGCUUGGAGUCAUAGGCGAUGAGAGGGACAUUAGGAUAUUAUGAAGCCCGUGAACUCAACUCCUGAGAAGGACGCAGCAGAGCGAGAGAAAAGAUGGAAUAAAAAGGCCUACCUCAUUGGGCUCGUGUGGGUGAGGAGAACUGAAGAGUCUGAGAGCGCGGCACGAGCCAGAGGCUACGGAAAACACUGCCCUCCUACACUCCACCUUGGAGAGACCCAGAAAAGAACAAGCUUCAUUUGUAAAAAAGGAAAACAACUCAGGCAAUGGGGGUGGCUUAAAGGCACUCUACAGUGUGCAGAUGCCUUCCACUUCUUCCAUCUGCCCUGUCUCUCCAAGAACCCCUAUGGCCCCGGUCUCAGAACAGAGCUGAGUGCAGAAAUGAAAAUCUAUGGCUCUGUGUUCCAAAACGAUGAAGAAUUUCAAGAUGGUGGCAGUGGUAAAAUCUUUCUCCAGGAAAAAUCUGUCCUUGGCCCAAUGUGUAAACACUUGCUGAGUAUUGUGAAACCAGCAACUUGUUCACAAUUCUUCUGAAUUUCUUGGGAAAUUUGAAGUGGAGUACCUGUACCAACAUGAAAUGACACGAAUUUAAGUGACGCUCAACAACGAAAAGCAAAAAGAACCAAAGAGGAAGCAACUGAAACAACAUCUGGAUGUAUUUAAAAAUAUACAAUGCCUCCAAAAUCAGGUGUCAUUAAUGAAAAUUCUGAAGAAAUGCCACCGGACAUAGCCAACGCACCUACGCUGUUGUUAUUCAUUUCCUGCUUUUCACAGAAAACAAUUUUGUUGCAUGGAAGAUCGUGAACUUCAAAGGGCAGAGGGGAAACUGUCCCUUGGCCUCUACCCCUCCAAGGCCCCACUUUUUUGUCAACACUCCUUGGACGCAGCAGAAGUAUGAACAUAAUAUGGUCCUGAAUGAGGCUGAGUCUUUGGGCGCAGAAGACCCGGGUUAAUAAAAAUAGGAAGGUAAGAAAAGAAAAGAAAAAUCAAGACACAUCAUAGGACUAAAUUCCUAUUAUUUAUCCACUCAGGAUUGACCACCCCUUUGGGCCAGAUAGUUGUACCCCCAUGUACCAGGUGGGCACAUGAAGACACAAGAAGUGCUGUGAUGGUUCAUUUUGCACGUCACCUUGCGUGGAGUAUGCCAACUCAUUGUUUGGUCAAACACUAGUCUGGACAUGGUGGUAAAGGUAUUUUUUAGAUGAGAUUAACACUUAAAUCAGUAAAGCAGGUUACCCACCAUACUACGGGUGGGCCCUGUCCAAUCAGUUGAAGGCAUUAAGAACAAAGAUUGAGGUUUCCUAAAGAAGAUGGAAUUCUCCUUGAGACUACAACAUAGAAACCCUAUCUGAGUUUCCAGCCUGUUGCCCUGUGGAAUUCAAACUCAGGACUCCGGUCUAUGACAUUAACCCUCACUUAACUUUUCAGCCUGCCAGCCUGCCCUAUGGAUUUCGGACUUGCCAGCCACACAAUUCCUUAAAAUAAAUCUCUCCGUCUCUGUC

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