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Homo sapiens (human) chondrogenesis-associated transcript (CISTR) URS000075EA90_9606

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CISTR: CISTR is a long noncoding RNA with three exons [PMC5624354]. It is one of several long noncoding RNAs, including CAHM, ABALON, HEIH, NKILA, FOXC2-AS1, MHENCR, FALEC, HOTAIRM1, and CISTR itself, that have a G-C concentration above 50% [PMC5624354]. CISTR is an evolutionarily conserved gene that plays a role in mesenchymal and prechondrogenic development [PMC9008751]. It has been suggested that CISTR, along with IFT140 and RGS14 genes, could serve as potential novel candidate blood methylation biomarkers for diagnosing liver fibrosis in non-alcoholic fatty liver disease (NAFLD) [PMC9008751]. In a study comparing NAFLD patients with and without liver fibrosis (NSLF and SLF groups), it was found that the methylation levels of the CpG island regions of CISTR were significantly higher in the NSLF group [PMC9008751]. Additionally, six hypomethylated differentially methylated positions (DMPs) were identified in the genes CISTR, IFT140 and RGS14 [PMC9008751]. These findings suggest that DNA methylation alterations in genes like CISTR may be involved in the progression of liver fibrosis in NAFLD patients. Furthermore, alterations in the frequencies of several genes including CISTR were found to occur simultaneously with alterations of CD276 [PMC9885708]. These findings highlight the potential role of CISTR as a biomarker for liver fibrosis diagnosis and its association with other gene alterations.

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Gene Ontology annotations

Sequence

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UCCCCCACCUCAUCCACCUCUGACUGUGGAGAGGGGAAGAAGAGAUGUUGGGCUAAUAGUUUCCAAGGGCCACAGUUCCUCCCUCUCCCCUCCUUUUUAUCCACACAUCUGUUUCCUGAGCCAGCUCACAAAAGCUUCCCUAAGUCAGGACUUGCCUGCGCUCUUCCACAGGACCUACCAAAGAGUGAACAUUUCAGGACCCGGAGUCCCCUGCUAUCCAGCUAAUCAGGUUAUCCAAAAAACUGGUGCUGGGGAAAGCAUAUGGGAUUUGCAGAGAAGAAAGAACCAGAGGAUCUUGGGCAAGAUGAAGACAGCUGGUGAGACAUGGACUGGAUAGCUGUUUGCCGUUUUGCUGUUUGCCUCCUUGUCACGACCUCAGCGACGGCAGAUGGAGCCAGUGGAGGGAGAGAGACAGACGGCAAUGCUUGGGUAGCCAGGGCUCCCUGCCGGCCCCACUCCUCCUGCAGACACGAGCACGCACACACACACGCGCGCAAAACACACACGCUGCCCUUCGCCACACGUAGCCAAGUAAAAUACACAAAAAGCAACUGAGAUACCAUUCGCACAUGACCACAUGGAAACACACAAAUGAACAAACGCAUUCAGGCAUAGCCACAUGCCAGUCACACAGAUGGAUAGACAAGAGCCUGGGGUACAAAGCCACAUGGCACAAAGCCACCUGGAUGUAUAUGCCCCUACACACGCACACAGAAAAAAACAUGCAAACUUAAGUACACACCUAUCCAGACAAGUGUGAGUGCACACACACACACACUCACACACUCUACCUGACACGUUAGUGCAUCCCCAUUGGGCCCCAGUUUCUCUCAGCAAAUUCAGAUCACCCAGCCUG

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Publications