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Homo sapiens (human) MIR155 host gene (MIR155HG) URS000075EA4E_9606

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MIR155HG: MIR155HG is a long non-coding RNA (lncRNA) located on chromosome 21q21 and is considered the primary microRNA of miR-155 [PMC8922801]. Knockdown of MIR155HG has been shown to decrease migration in SiHa cells, and this effect can be reversed by SRSF1-OE [PMC7695692]. Additionally, MIR155HG knockdown reduces the proliferation and invasive ability of cervical cancer cells [PMC8610141]. In HPMECs, reduction of miR-218-5p does not affect the MIR155HG-MUT reporter, but enhances the luciferase activity of the MIR155HG-WT reporter vector [PMC7070147]. Studies have shown that MIR155HG polymorphisms are associated with liver cancer risk in Chinese populations [PMC7304092], and that MIR155HG SNPs are associated with colorectal cancer risk in Chinese Han populations [PMC6687631]. In glioblastoma multiforme (GBM), MIR155HG is closely associated with proliferative activity and apoptosis resistance [PMC6427903]. Furthermore, MIR155HG has been shown to encode a micropeptide that regulates antigen presentation and suppresses autoimmune inflammation in psoriasis [PMC8586455], as well as drive macrophage polarization towards an immunosuppressive phenotype in GBM [PMC9655812]. The isoform -3p of miR-155 is silenced by hypermethylation of its host gene, MIR155HG, promoting lymphomagenesis [PMC7587593]. The expression levels of both miR-155 and its host gene, MIR155HG, have been correlated with overall survival rates in breast cancer patients [PMC9525116], as well as immune checkpoint molecular expression levels in different tumor types such as CHOL and LIHC [PMC6885872]. Genes positively associated with MIR155HG expression are enriched in inflammatory and immune responses [PMC8922801].

Genome locations

Gene Ontology annotations

Sequence

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GCCGAGCCCGGGCCCAGCGCCGCCUGCAGCCUCGGGAAGGGAGCGGAUAGCGGAGCCCCGAGCCGCCCGCAGAGCAAGCGCGGGGAACCAAGGAGACGCUCCUGGCACUGCAGAUAACUUGUCUGCAUUUCAAGAACAACCUACCAGAGACCUUACCUGUCACCUUGGCUCUCCCACCCAAUGGAGAUGGCUCUAAUGGUGGCACAAACCAGGAAGGGGAAAUCUGUGGUUUAAAUUCUUUAUGCCUCAUCCUCUGAGUGCUGAAGGCUUGCUGUAGGCUGUAUGCUGUUAAUGCUAAUCGUGAUAGGGGUUUUUGCCUCCAACUGACUCCUACAUAUUAGCAUUAACAGUGUAUGAUGCCUGUUACUAGCAUUCACAUGGAACAAAUUGCUGCCGUGGGAGGAUGACAAAGAAGCAUGAGUCACCCUGCUGGAUAAACUUAGACUUCAGGCUUUAUCAUUUUUCAAUCUGUUAAUCAUAAUCUGGUCACUGGGAUGUUCAACCUUAAACUAAGUUUUGAAAGUAAGGUUAUUUAAAAGAUUUAUCAGUAGUAUCCUAAAUGCAAACAUUUUCAUUUAAAUGUCAAGCCCAUGUUUGUUUUUAUCAUUAACAGAAAAUAUAUUCAUGUCAUUCUUAAUUGCAGGUUUUGGCUUGUUCAUUAUAAUGUUCAUAAACACCUUUGAUUCAACUGUUAGAAAUGUGGGCUAAACACAAAUUUCUAUAAUAUUUUUGUAGUUAAAAAUUAGAAGGACUACUAACCUCCAGUUAUAUCAUGGAUUGUCUGGCAACGUUUUUUAAAAGAUUUAGAAACUGGUACUUUCCCCCAGGUAACGAUUUUCUGUUCAGGCAACUUCAGUUUAAAAUUAAUACUUUUAUUUGACUCUUAAAGGGAAACUGAAAGGCUAUGAAGCUGAAUUUUUUUAAUGAAAUAUUUUUAACAGUUAGCAGGGUAAAUAACAUCUGACAGCUAAUGAGAUAUUUUUUCCAUACAAGAUAAAAAGAUUUAAUCAAAAAAUUUCAUAUUUGAAAUGAAGUCCCAAAUCUAGGUUCAAGUUCAAUAGCUUAGCCACAUAAUACGGUUGUGCGAGCAGAGAAUCUACCUUUCCACUUCUAAGCCUGUUUCUUCCUCCAUAUGGGGAUAAUACUUUACAAGGUUGUUGUGAGGCUUAGAUGAGAUAGAGAAUUAUUCCAUAAGAUAAUCAAGUGCUACAUUAAUGUUAUAGUUAGAUUAAUCCAAGAACUAGUCACCCUACUUUAUUAGAGAAGAGAAAAGCUAAUGAUUUGAUUUGCAGAAUAUUUAAGGUUUGGAUUUCUAUGCAGUUUUUCUAAAUAACCAUCACUUACAAAUAUGUAACCAAACGUAAUUGUUAGUAUAUUUAAUGUAAACUUGUUUUAACAACUCUUCUCAACAUUUUGUCCAGGUUAUUCACUGUAACCAAAUAAAUCUCAUGAGUCUUUAGUUGAUUUAAAAUAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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Publications