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Homo sapiens (human) AGAP2 antisense RNA 1 (AGAP2-AS1) URS000075E9B8_9606

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AGAP2-AS1: AGAP2-AS1 is a long non-coding RNA (lncRNA) that has been extensively studied in various cancers, including melanoma [PMC9192260], ovarian cancer [PMC6604673], colorectal cancer [PMC7936697], breast cancer [PMC8156384], hepatocellular carcinoma (HCC) [PMC7469350], lung cancer [PMC8110970], prostate cancer [PMC7546420], gastric cancer [PMC6277609], glioma [PMC6594811], and clear cell renal cell carcinoma (ccRCC) [PMC7202287] [PMC9938775]. AGAP2-AS1 has been found to have diverse functions in these cancers, such as downregulating MEG3 expression in ovarian and melanoma cells [PMC6604673], increasing cell proliferation rate in colorectal and lung cancer cells [PMC7936697], and being implicated in trastuzumab resistance in breast cancer [PMC8156384]. It is positively regulated by miR-16-5p in HCC [PMC7469350], promotes tumor-cell proliferation in non-small-cell lung cancer [PMC8110970], and binds with EZH2 and LSD1 to suppress the expression of P21 and E-cadherin in gastric cancer cells [PMC6277609]. AGAP2-AS1 has also been associated with poor prognosis in glioblastoma multiforme (GBM) [PMC6594811], inhibits cell migration, invasion, and proliferation in epithelial ovarian carcinoma (EOC) [PMC7391213], and has prognostic value for low-grade gliomas (LGG) [PMC9938775].

Genome locations

Gene Ontology annotations

Sequence

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AGCGCCUAGGAGCCCGUACCGCUGGGGACCUCCCCUUCCGCGAACCCCGAGCGGGUAGACCCAGAGCAAUCCGAGUGUGGAAACAAUGGAGAGGGGGCGUGUUGAGCUGGGGUCUCCAUGCCUCGUUGGGGAGAGGGAGCUCACGUACCCACAGCAGCAGUUGCGUGAUGACGACGUGGGCGAGCUCGGCCGCCAGGUGGAGUGGGGAGCGCAGCUGUGGGUCCUCUACGCUGGUGUCGAGCGGCCCGUGUCGCGCAUGGGCCAAAAGCAGGAGAACGGUAGCCACGUCCUGGGCCUGCACGGCGGCCCACAGCUGGCGGCCCAGCGGCUCCUCCGAGGUGCUCAGCGGCGCCAGGAACAGUAGCUGCUCGUACUUGGCGCGAAUCCACGACUCGCGCUCCUCCCUGCAAGACCAGGGAUCAACGGAAAAGGCUCUAGGGACCCCCAGCCAGGACUUCUGCCCCUACCCACGGGACCGUCUCAGGUUCGCACACCCUCAGCAACCCUCCCCCCGCUCUGUUCCCUCACGCUUACCGCGAAGAGUCCCGCGAGGGCUUGGCACGGCCUCGCGUGUCGCUUUCCCACACGCGGUUGGCCGUGUCGUUGCCAAUAGCCGUCAGCACCAGGGUCAGCUCCCGUGGCCAGUCGUCCAAGUCCAGCGAGCGAACGCGGGACAGGUGUGUGCCCAGGUUGCGGUGGAUGCCAGAACACUCGAUGCAGAUGAGGGCGCCCAGGUUCAAGCUGGCCCACGUGGGGUCUGCGGAAGGAGCGUAGAGGUCGGCUCCCAGCCGGGCAGCACAGGCACCCCGGCAUUCACUACACUCCCUAGCCCCUCCGCUGCCUCCUGGCACUCACUGGGGGCCCCGCAGUCCACGCAGAUUGAAUUCCCCUUGGCGUUCCGGAUCGCCUGGAUGGCCACGGCCUCGCUUUGGCUGUCUGUGCGCAGCUGCAGAGAGGGUUUGGGUUGGCACUGACUCUGCCUCCAAGCCCCACCUCCUUCUCAGACACCUCUGCUCUCCUCUCACACGACUUCGGCCGUGUCGUUGCCAAUGGCCGUCAGCACCAGGGUCAGUUCCUGCGGCCAGUCCUCCACUCCACCUCAAACUCUUACCUUGACCUUGCUGCUCUCACAGCAUUGCAGACUGGCUAGGAUCUGACUCUCGAUGGCCUGGACCCAGGCAUCCCGCUCCUCAAAACUGGCUGCCUCAAAGUGCCACGUCUGACCCGUGCUGGACACGAUCAGGAACUCAAAGUUUUCCUCUGAGUGGGGGAUGGGAUGGGGUCAUUAAGGGACAGAGUUCAAGCAGGGGCUGCCUUUCCCAAGACCGUCCUCCCUGAUGUCCAUCCCGAGCCCCUGGGAGUGGGGCAGUGGGGGUAGGGAAAGCAGAGGGUGGGGGGCAGCAGGAAGCCCGAGCACAUGCAGGGGAAGGCGGGGGCACCCCCACCCUUCUGCACCCCAGCUGAGCGCCCCUCCCGGCUCCCCACUUGUUACCUGCUUUAUAAAUAUUUCUUAAACUACCAAAGGAUUUUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications