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Homo sapiens (human) small nucleolar RNA host gene 20 (SNHG20) URS000075E632_9606

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SNHG20: SNHG20, a small nucleolar RNA host gene, has been implicated in various types of cancer, including nasopharyngeal carcinoma [PMC6257038], gastric cancer [PMC7798103], hepatocellular carcinoma (HCC) [PMC7537701], breast cancer [PMC7417930], glioma [PMC8376724], non-small cell lung cancer (NSCLC) [PMC6371528], ovarian cancer [PMC5754315], and oral squamous cell carcinoma (OSCC) [PMC6307847]. It has been shown to promote cancer progression by inhibiting the expression of tumor suppressor genes such as p21 [PMC5655232] and miR-342-3p/MTDH axis [PMC9399968], and by regulating the GSK-3β/β-catenin signaling pathway [PMC5655232] and ADAM10 expression [PMC8116851]. SNHG20 is also associated with poor prognosis in various cancers [PMC8819090] and is highly expressed within tumor tissues compared to healthy tissues [PMC8651371]. Furthermore, SNHG20 has been found to be involved in ceRNA networks and can regulate the expression of genes such as BUB1, TMEM164, and DDX17 [PMC8819090] [PMC8641522] [PMC4992210]. The correlation between SNHG20 and other genes/proteins such as ZRANB2 and EZH2 has also been investigated [PMC6371528] [PMC5655232]. Overall, SNHG20 plays a significant role in the development and progression of various cancers through its involvement in different molecular pathways [PMC9921150].

Genome locations

Gene Ontology annotations

Sequence

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AAGUUGCUGACGGAGCUACUUCCGCCCAGGGGAGUGGGAAGUAAGUGGAGACACGUGCUUUGGCCUGUUGGAGGGGAAACCCGCUCUCGCCUCCUGGUGGUCGCCGACUCGCAGUCCGCAGGAUGACUCAGGGCAGCCCUGACCACAGUUCCGCCGCCAUCGGCCCUAGCCUGCGGAAUUGGGCUCGCCCCGGGACGAUAACAGAGCUCUGCCGGGGGCUGGAGGCACUGACCGGGUGACCAGAGACCCAGAGACCAGACCCCCUCCACGGCGCCCGGGAUUUCGGGGACGGCUUCUCCCAUCGCAAGUUUCAACAGAAAAUGAGAAAUAUCCCCCGACGAUUGGCUGAAAACAUGCAGCAACCACUAUUUUCUUCCUGCCCCUCGUUGAUGAGAGCAUUCGAAGUGACCUCAGCAGGGCAUCCAGGUCAGUUUCUGGAAGACUUGUGUGUGUGAUGAAUGAAUAUCUGGUUUUGUCUCUGCUGGGCCUGUGUGCCUGGAAAGGAAUUGUUUUGGCCUAGGAUCAUCCAGGUUUGUUUGGUUUAGUUCUUGACCACAUAUUUUUUGAAUGGUGACUGCUUAAGACCCUGUUGUGUAUGGCUAUAAAUAGAUACACGCCAAGGUGACCACAUACUCUGUGGUUCCUGUGCCCGCCGGCCAUGUGUCUGAGUGUGUAGCCUCUCAUCAUCUAAAGGAACUUUGGCUGCAGAGGGGAGGCCUGGUCCCAUGGGAAGUUUUGGGAGCGCAGCAGCAGGUGGGUUCAAACGACCCAGCAAGUGCCUCCUUAGCACUUAGAGGCGGAGGCCACCACGUUGUCCACGUGGGGUUUCUGAUCCCAGCUCCCCACCAGCCUGCUGGACCUCGGGCAGGUCCCUCCCUGUUUGUACCUCCAUUACUUCUUCAGUAAGAUGGGGACACUGAAGAUGACCAUGCCUCCCACCAGAUUGGUGCUUUUUUUGUUUUAAUAAGGGACAGAGUCUCACUAUGUUGCCUAUAGGCUGGUCUCAAGCUCUUGGCCUCAGUUUUCCUGCCUCAGCCUUCAAAUAUGCUGGGGUGACAGGCAUGAGCCACUGCACUGGCCCAGAUUGGUACAUUUGAGGGUUAAAUGAGCAAAUCCUAUAAAGCACUCAGGAGAGGGCUGUGGGGUUUGGGCUGGGGCCUGGGAGCACUUUAGACGUGGUAGCUAUGUUGUUGUCACCUUUCUCCUCUUUCAAAGCAUUUUUUGUUUGUUUGUUUUUGUUUUUGAGACAGAGUUUCGCUCUUGUGGCCCAGGCUGGAGUGCGGUGGUGUGACCUCGGCUCACUGCAUCCUCCGCCUCCCGGGUUCAAGUGAUGGGAUUACAGGUGCCUGCCACAACGCCCAGCUAAUUGUUUGUAUUUUUAGUAGAGACGAGGUUUCACCAUGUUGGCCAGGCUGGUCUCGAACUCCUGACCUCAGGUGAUCCACCUGCCUUGGCCUCCCAAAGUGCUGGGAUUACAGGUAUGAGCUACCGCGCCCGGCACAAAGCAUUUUCAGCUGUGAAAUUCCCUGGGGUGCUGCAGUAGAGGAAGGUUUGGGGUCUUGACGGGUGCUAUUUGCCACGGAAAGAUGCCUUCCUGCUCCCAGGGCAGGAGAGCCGAGGUAAGACUUACUGUAGGCUGUCGUUUUUUUUGUUUGUUUUUUGUCUUUGCGAUGGAGUCUCACUCUGUCGCCAGGCUGGAGUGCAGUGGCAUGAUCUUGGCUCACUGCAGAACCUCCACCUCCCAGGUUCAAGCGAUUCUCCUGCCUCAGCCUCCCAAGUAACUGGGAUUACAGGCACAUGCCCCCACAACCAGCUAAUUUUUUAUUUUUAGUAGAGACAGGGUUUCACAUGUUGGCCAGGCUGGUCUUGAACUCCUGACCUCAGGUGAUCCGCCCGCCUCGGCCUCCCAAAGUGCUGGGAUUACAGACAUGAGCCACUGCGCCCAGCCAGGCUGUUGUUUUUUUACCUCCUUGUUUGCACAAUUUGGGCCACUCACAAGAGUGUAUACCCUGUGAUAAACAGUUACCUACAUUCUCCUCUGCAUGCUUGUCUUUAGAGGAAGGAAAUGUAUUAAUUGCCCAAAGUAAUAUAUUGUGUUAAGAUGUGAUAUAUACUGGGGAAAAAAAAAGUGUAUAUUGACAUUUCUGGAAUAAACCACUUUGAUUCCCAAAAAAAAAAAAAAA

Taxonomic tree

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Publications