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Homo sapiens (human) long intergenic non-protein coding RNA 1343 (LINC01343) URS000075E3E5_9606

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LINC01343: LINC01343 is a long non-coding RNA (lncRNA) that has been investigated in relation to breast cancer (BC) [PMC9484965]. In a study, higher expression levels of SFN, LINC01343, and CCDC18-AS1 were observed in cancer tissue compared to the control group [PMC9484965]. The study also found that CCDC18-AS1 and LINC01343 can affect the expression and function of the SFN gene [PMC9484965]. Furthermore, a significant correlation between CCDC18-AS1 and LINC01343 was observed, suggesting their interaction in BC pathophysiology [PMC9484965]. The study also identified SFN as a potential biomarker for BC diagnosis, along with LINC01343 and CCDC18-AS1 as strong biomarkers [PMC9484965]. LINC01343 was found to be overexpressed at stage III of BC and in nonmenopause ages compared to the control group [PMC9484965]. Additionally, LINC01343 has been associated with type 2 diabetes (T2D) and coronary artery disease (CARD) [PMC9484965]. The dysregulation of SFN, CCDC18-AS1, and LINC01343 may play a role in tumor invasion and metastasis in BC [PMC9484965]. The study suggests that CCDC18-AS1 can control SFN gene expression by repressing hsa-miR-4462, while LINC01343 can directly target the SFN gene [PMC9484965]. In another study analyzing patient prognoses in BC, 13 lncRNAs were significantly positively associated with overall survival (OS) and disease-free survival (DFS), including LINC01343. On the other hand, eight lncRNAs were correlated with poorer prognoses. [PMC6095106]. Furthermore, LINC01343 was identified as one of the differentially expressed immune-related lncRNAs in BC, with low expression in the high-risk group [PMC8187926]. In conclusion, LINC01343 is a promising biomarker for BC diagnosis and may play a role in BC pathophysiology. Further functional studies are needed to understand its role at the cellular level and its potential implications for BC diagnosis and treatment. [PMC9484965] [PMC6095106] [PMC8187926].

Genome locations

Gene Ontology annotations

Sequence

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UAAGUCAUGCGUGAUCAUCAAAUCAUUUGAUUAAUUCCCUUACUCUUACAGCUGCCUCAGGAUAUGGUUCAGUCAUCACCUCCUUCAUCCAGCCUUCUCUACCUCUUUGUCUUAACAUUGAAAUGGCCAGCGUGUUCUUCUACCUGCCUGCCAGACAUGCAGGCCCAAGGUACCAGGAGGCAGAUGCUGACAGAUGCAUCUCAGUAUGCCCGGCACCUCCACCACACAAGGGCUGUGCUGGUUGCUGUGGGAAUGCUGCAGGGCACAAAACGGAUAAUGCUGGAGGGAGAAGACAGCAAACACAAGGCUCAAGAAACUCCAGUAUGUAAGAAGAGGACAUGCACAAUGGAAGAGGGAAGCCACCAUGCAGAAUGUCGGGGUGCACUUUUAAAUGGGACAGUCAAGGGAUCAUCCUGGCAGCUAUGUAGAGCAUUACUAUAGGGGUCAAGUACCGCAGCAGGGACAGCAAUUAGUAGGCUACUGCAAGAGUCCAGAUGAGGAAACUGAGGCUUGGCGUCUCAUUGAGUGACCUACCCAAAAGUUACCCAAGGAGAAAUGGGCUCGCAGAGAUUUGAAUCCUGGUCUCCGGCCUUCCUUUAGACACUUGGGGUGCUCCCAAGUCUGCAUUUGGAGAGGGGAACAGCAUUAAAGUAUCAGCUGGAGCUUCUCAGCUUGAAAUCCUAGGCCUCUUCCAGAGGCCAGAUGUUCGGAUGGUACCAAGGGGCUCUCCGCUGAGUCCUAGGCUGGGAGCAGAGAGGGAGGGGACUCUGUUACCAAAUCCCAGGCUGGGCACUCCCAGGGAGUCCCUUCCUCCCCACCUGCAUGGCAUCUGGCCUCCGCCAGCUCCUGCCUGGCUGCCAGAUAUACCAGCUGUGGCUCCUCUCCACGGAGAGUCUCAUUUAUUAAUUAACGUGGACGCCAAGGGGGCAACUUCUCAGGCCCAGCCUCAGAGCAGAUCUUGGCACAUUUUUCAGACUUUGUUUAAUAAUUUAUCAUCUUUUAAUCAUAAAAAUAAUUAGCACAAGAGUGAUAAUCUAUGCUCUGCCGAGAGCAGACCAACGGAGGAAUUUUCAGACAGUGCCAGAACCCAGAGAGCAGAGCUUUGGCAGCGAGGAGAGGAAGGUUGGCUCCAGGCCAGGUGUCCUCUCCAGGACUGGCCCCUGGGAGUCAGGUGUCAAAGAUGCCGUCUGGCUUUUGGGGGAACUCGAGGACCGUGCUGCUUUCCUGGGAAUUUGAGGCUCCUGCUCCUAACUCUGACUUGGCUCACUGGAUAGCUCUCUGGGAAGUUCCUUCUCUGGGUCUUAAUUUUCCCACCUGUAAAAUGGGAGUUCAAUUAGAUAAUGAGUAAGGACACUUUUGUUCAAGGCGCCAUGAUCCAAUGAGAUAGCAAAUGUAGAAGCAGUGGCUGUGGCAGUAAAGACAGUGAGCUGGAGUGCCCAUGAGAGCCACGAAGCCUUCCACAGUCCCCGCCACCUCCCACCCCGCCAGCUUCUGCAUCCCCAGGUGCUCAAAGAGCCCUGGGACAGACUCAGUUCUGCCAGGUAUAAGCCGUGUGGCCUGGGGCAAGUCCAUCUCCUCUCUGAGCCUCAGUUUACCCAUCUGAAAAGAAAGAGUGAUCGCUCAUGUCCUGCAGCUCUCCCAGAGAAGAUCCAAGGGAGAGGAUGACAGGGUUACCCCUUGGAGACAUUGAUCUCAUUCUGCCCCACAUUUAACUGCCACUCCCUGUCCAGACUUUCGGUUCUAGAGGGCAGGGCAGGACUGCCUCAUCCUCUGUGCCUGAUAGCCCUGGUAGUGACCGAAUGAGCUCAAUGUUCUGCCAAUUCCAGCAAGGUGUCUUGAGAUUGUUCAACCUGUGCAGGCAGACACAUCCUCCCACCAGGGCGGCAGCACGGUCCGGUGACUGUGGGUAAAACCACAGCAGUUCAAGAAAGCAACUCCUCCUCUUCUUGUGGGGUCUUGUACAAGCUGCUUUGCCUCCAGCUGCCUCAGUCUCUUCAUGUGAAAUUGGGGAUAUCUGUCUUAGAUUGGGGGUCCCCUGAAGCAGACCUAGAGACAAGAAUUCAAGAUCAAGUCAUUUAUUUAAGAAGAGAUCCUGGAAGUUCCAGUAGGGAGUGGAGAAGUGAGACUGGGAAGGGGAGGAGAGCAAUGAAAGGCGCGUGAAUGAGCUGGUGACCACGCUGGACCCAGGCCUACUGGGGCCAUCUCAAGGGUUGGCAAACUACAGCCCACAGGCCAAAUCAGGCCUGCCUCCUGAAUUUGUAAAUAAAGUUUUAUUGGAACACAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications