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Homo sapiens (human) long intergenic non-protein coding RNA 475 (LINC00475) URS000075E2BA_9606

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LINC00475: LINC00475 is a long non-coding RNA (lncRNA) that has been implicated in glioma, a type of brain tumor. Analysis of overall survival in glioma patients showed that those with amplified LINC00475 had shorter survival times, both in low-grade glioma (LGG) and glioblastoma (GBM) [PMC7810941]. Subcellular fractionation assays revealed that LINC00475 is primarily localized in the cytoplasm of papillary thyroid carcinoma (PTC) cells [PMC8651061]. Research has also shown that LINC00475 can suppress the expression of miR-449b-5p, which is known to negatively regulate the leucine-rich repeat-containing G protein-coupled receptor 4 [PMC7425262]. Similarly, another lncRNA called LINC00319 can bind to miR-450b-5p and reduce its expression, leading to increased expression of EZH2, a target of miR-450b-5p in lung adenocarcinoma [PMC7425262]. Therefore, it can be concluded that overexpression of LINC00475 may suppress miR-449b-5p expression and increase the expression of AGAP2 in hypoxic glioma cells [PMC7425262]. In experimental studies, GAPDH or U6 was used as an endogenous control for measuring the levels of LINC00475 or miR‐141‐3p, respectively [PMC7810941]. These findings highlight the potential role of LINC00475 as a regulator in glioma and its interaction with other molecules involved in cancer progression.

Genome locations

Gene Ontology annotations

Sequence

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GUGACUUCGCGCCGCUGUGUGCGCCUCCCCGAGCGCCGGCUGCGCCCCCCAGCCCGGCCCGGGGCCUACCGCCUGCCCGGCCCCCUGCCACUGCCAGGAGGACGGCAUCAUGCUGUCUGCCGACUGCUCUUGAGCUUGGGCUGUCCGCCAUACCGGGGGACCUGGAUCCCCUGACGGCUUACCUAUUCCAUGUCAGUAGUGGCAAACCUUUACAGGAUUAUGAAUACAAAAUGCCACUGGUCUCCUGAAGAUACAGCAGCAAAAUGAAACAUCCACAAAUAUGACUUAAAUUGAGAAUAUGUGCAUGUCUAUAACUCCACCCUUCACUGUGCUGCGGUUGUUCUCUGGACCACUCCUAUUUCAUCAGUGUUAUUGUCAACCUGAAGAACAAGCAGAAAGAGGCUCUCUGAAAUGAAAUGGAUGCUUAUUUGGGAAGAGAGCAUUGCAACGGGAAUACACAUGCCAUCGUAAAUGACAAGAAUAUUCAGGGAGGACCCCAUCACAUUUGGCUGCCAUAUCUCCUUGGACUCCUCUUGGCUGUGACAGGGUCUCAGACGGCCCUUGCCGUUGAUGACCUUGAUGGUUUGAAGAGCCCUAAUCAGGUGCAUUGCAGGACGCUCCUCAGUUGGGAUUUGUCUGAGGCUUUCCUCGUAAAUAGCCUGGGGUUAUGGGUUUUGGGAGGAAGACCACACAGAUAAAUGCCAUUCUCAUCAUGUCAUAACAAGGGUACACACGCUGCUGACAUGACUCUUCACUGACAGUGGUGGCUGUAGUCGGCUGGCUGAGGUCUCCCCACUGUGAAGUCCCCCUCUCCAUGCUGUACUCUCUGGAAGGACGUCGCCAUGCACAGCCGACACUUAGGGGUAUGGGUUGUGCUCCACUUCCGAGGAGGAGAAGUAGCUACAUGAGUGACUGGGAAAUGUCCUGGGGGGGAUACUCAUCCAUGCCUCCACAUUACUUAUGUACUCAAUCUUUUAUUUAUAUUGCUAUGGACUCAUGGAUACUCAGCCCAUGCUCGGGCUGGACUCCAGUGUGACUUUGCUUCUUUUCCUGCUCAGCUUCUUCGAGGUUGGCCUUGGUGAGCUCCCGUGGUGGGUUCCCAGCUCCUGUGUGCCUCUGACAGGUGCUCAUCACUUGGCUUUUUGGGCAUCUCCUUAAUUUCUGCUACUAAAGAUGCUCCUGGCUUAUCUUCUGCAUGUCCUGCCUUUGCCCUUGAAUCAGUCAAUUCUCCAAGAAGCUCUGGCUCCUUUCCUAGAACAGUGUUAGAAACCAAGAUCUGGGCACUGGUGUGUUCAUUGCUAGUGAGGUGUUGUUGCUUCUAGACUCUCUCAGCUGAUAGAGCAAGGGAAUGUUUAAGCCAUUUAGAACAUAAAUGCAUUCAUUUAAAAACAUGGACUAUGUAUUCACUGUGCCUUGGGCCCCAAGCUGGGUGUUGAGGAUCUUGAGAAAAUAAAUCAAGGAAGCCCAUGGUCUAGGGUAGUGCUGGUGAGGAGAUAACAGACUCUUGAGAUGGCACUAGGGCCAUGGCGGAGACAGACCUGGACACUAGUGGGACCCAGCAAAGACCCACAGCAGCCUGGGGAGGCGGCUUCCAGAGUGCUGCGACUUUGGAACAUGAAUACUCCUGAGGGUUCACAAACGAGCCUGGGGGGUAUUCCAGGACCAGCUGGUAGGGGGGCAAAGGUUGGGUCAUGAACUAUGGGGAAUGCAAGAAUUGCAAGAGGUUGAACAUGCCUGGGGGUGCAGAGACAGAGGCUGAGGUGCAGGGCAGUCUGAGACAUGGUUAGGAGCCUGGGCAUUCUCUUGAGAGACAGGGGAGAAGAAAAUUCAGAUGGAGCGUUCAUUUCAGGAAGGCCACCCUGGGAUCUGGGCAGGAGAUGAAUACCUGGCAGGGUCAGGGAAGGGAAGGUAAUUGAAAGUUUACAAAAACAAAACCCCAUUCACAUUCUUAAAGUAUUCUUCAUAGAGGUACUAUUUCAAUAAACACAUGCUUUAUUUGU

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