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Homo sapiens (human) microRNA hsa-mir-3117 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-3117 precursor URS000075E1C7_9606

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MIR3117: MIR3117 is a microRNA that has been identified as a hub gene associated with patient prognosis [PMC9660063]. It is regulated by HNRNPC [PMC9660063]. The risk score for MIR3117, along with other hub genes, can be calculated using a specific formula [PMC9660063]. MIR3117 has also been found to have lower expression levels in rice, maize, and sorghum [PMC6358896]. In various types of cancer, including breast cancer, colon cancer, ovarian cancer, and liver cancer, MIR3117 has been identified as one of several miRNAs that post-transcriptionally regulate PHLPP2 [PMC8078721]. In Triticum subgenome A and in Ehrhartoideae and Pooideae subfamilies of plants, MIR3117 has shown conservation and rapid evolution [PMC6651130]. Additionally, in Triticum wheat species, MIR3117 is part of several miRNA families that target NB-LRR transcripts and trigger the production of phasiRNAs [PMC7057497]. In a study on B‐ALL risk factors, the SNPs rs12402181 in MIR3117 and rs62571442 in mir3689 were found to be associated with B‐ALL risk through their effect on the MAPK signaling pathway [PMC7167988]. Finally, in miRNA expression signatures related to various conditions or diseases including B‐ALL risk factors or prognosis prediction models for breast cancer patients or patients with acute myeloid leukemia (AML), MIR3117 was one of the top-ranked miRNAs identified [PMC9284388].

Genome locations

Gene Ontology annotations

Sequence

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CCCUAAAGGGCCAGACACUAUACGAGUCAUAUAAGGGAAGGCAUUAUAGGACUCAUAUAGUGCCAGGUGUUUUGUGGG

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This sequence is found in 3 other species

2D structure Publications