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Homo sapiens (human) AFAP1 antisense RNA 1 (AFAP1-AS1) URS000075E0F9_9606

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AFAP1-AS1: AFAP1-AS1 is a long non-coding RNA (lncRNA) that is highly expressed in various cancers, including retinoblastoma, osteoarthritis, nasopharyngeal carcinoma (NPC), triple-negative breast cancer (TNBC), melanoma, and endometrial cancer (EC) [PMC6048204] [PMC8225811] [PMC7719841] [PMC8973689] [PMC8225811] [PMC7719841] [PMC8225811] [PMC7719841] [PMC8225811] [PMC7719841]. It has been associated with poor prognosis and shorter overall survival in retinoblastoma patients and other cancers, suggesting its potential as an unfavorable prognostic factor [PMC6048204]. AFAP1-AS1 interacts with proteins such as SNIP-1 and KAT2B, leading to the stabilization of c-Myc and YAP mRNA, respectively, and promoting the activation of the Wnt/β-catenin signaling pathway and the induction of epithelial-mesenchymal transition (EMT) [PMC8225811] [PMC7719841] [PMC6250734]. AFAP1-AS1 also regulates miRNA expression as a competing endogenous RNA (ceRNA) for miR-653-5p, leading to the upregulation of RAI14 expression and promoting melanoma progression [PMC7106910]. Overall, AFAP1-AS1 is involved in various cellular processes that contribute to tumor growth, invasion, metastasis, EMT induction, and poor prognosis in different types of cancer [PMC6048204] [PMC8225811] [PMC7719841] [PMC8973689] [PMC8225811] [PMC7719841] [PMC8225811] [PMC7719841] [PMC8225811] [PMC7719841]. Further studies are needed to fully understand the molecular mechanisms underlying its functions in these diseases [PMC6048204].

Genome locations

Gene Ontology annotations

Sequence

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GCUGCUGCCACGUAAGAAGUGUCUUUCGCCUCCCGCCAUGAUUCUGAGGCCUCCCCAGCCAUGUGCAACUGCGUGUUUACUGCUCUGGGCCCAGUGCCUCCCUCGCUCAAUGGAGUGACGGCAUCCAACUCACAAGACAGGAGACUCAACAGAAUGACCAAGUGGAGAAGACGUCUAAGUUCUCAGCGGUCUCAGCCGAAUGACUGAAGAGGAACCAGGGACAGGGAUGACUCACAUGGGAAGAGGACCCCACUUUGUUCUGUUUGAUUCUAAGAGGACACAGACUGCUUCAUUCAUUUCAGUUUCCCCAGCACCUGGCUUAACUCUCAGACAUGUUAGACGGUUUGUAAGCACCGGCUCUACUGAACUGGCAUCAAAUCAUGACCUGGUUCAGAAGAGACACGAGGACUGGAUCUGUUCUAAACAGAUUGUGCAAAGGGGAAAGACACAGACUCAGCAUUUCCACAGCUUUUAACAUUUCAGCGAGAGGUGAGAAAGCAUGUCAGGAACACAGGCCCGGCCGAUGAAAGUGUCUGAUGCUAACACAUGAACUGUCUUCUGCUGGGCACACUAAGGGGCCACAAGCAAGCUACGCCCCAGAGCCACUCCACAUUCUCUCUGGGUGCACUGGCCCUCGGCCACGCAAGGCCGCGCCAGCCUCCGAGGUGAGCCAGAAGGACACACACCUGUGGACUCGAUGUCCCUGACUUGGGCUCGAUGGCCAGCCCCAGGGUGACUCCGCCCGCCAGCGCUUUCUUCAGGCUCUCCUUGACCUCCGUCAGCUCCAGCUCCAGGCUGACACGCUCCGCCUCCUUCUGCCGGCACUCCUCCUCCAGCUGCUUCAGCUUCUCCUCCAGGAUCGCCUGCGGCUUCCUGCCUGGAAUUCCCAGAAACGCCGUUACUCCCGCGGCAGGCACAGGUUCUCCAAACAACAGAGAAGGCACCUGGUCCCCAAGAAGAACUUCCACAAAACGUCUGAGGUCGAGCUCCCCUGACUUAGGUCCUCGUUGUGAAACUUAAAUUCAGCAGUUCUCUAAGGGAUCAGAGUCCUUCUCCUACCAUUUCCCUUUGCUGCAGCCGUUGAGGACUCGGACCAGGAAAGAGGAGAUGCUGAUUCUGACGAAGGCCAGGAGCUCCUGGCUCUGGGCCUCAAUGUUCUCAUUUUAAAACGUGGACCCUAAACUCCACAGUUCCCAAAGCUGCCACCUUCUUGGAGUGUGAACCCUGUCCUCCCCUAACGCUCCGCCGAUCCUUCAGUCAUCUUAUUUGCGCCCGAGGCAAUGAACAGUAGCUCAGCUUGCAUCUCUACUGGACAUGGCACACAUUUCUUUAAGGCACAUUCACUUAUUUUAUUUGAGGUUUGCUGCAGUGACCUAAGAUGCACCCACUGGGCAGAUGAGAACACCAAUCCCAAGAGGUGAACGGACUUGUGCCCAGGGCCUGGGCCGGUGGUGGCCGGCAGGCGAGGUUCUCUUUUUCAAAGCCAAAAGCACUCCUGGCCCUCCUGCAUCUUCACUAUCCUGCAAGCUGGGAACACGGGAGAAAUGCUACUUCUGUCUCAUUAAACUCCAUGCCCCGUCCCAUUCUCUGGCACAGCCUCCUCCCGUAGGGUCAGCCUCAGACUGCAGGCCACAUCCUGGGCCUCCUAUAGGGUCAGCCCGACCUGCCCUGCCAACACCUGCCUUCCCUCCUCUAAACUCCAAAAGCAUUUCCCUUCAUCAGAUCAUUGAGGCACAAAGUCCAGCAAGGCUGGAGCUGCUAACCACCUGCUGGGUGUGCGUCAGCUCCUCCCCGCGCGGCGAGCCAUGGGAAGGCCACAGCCUCUUCUCUGGACCACCCAGGGCUCUGAGGCAUCUGAAGCCCCCGUCCCAGCCCAGGCCAGUACAAUCUCAAUCUAAGGAGCCAGUCUUCCGUAGUCUAAGCACCGGGCUGGAAGGGAGGCCAUGCGUAGGUAAGCGGUGCCACCCCAGGCUCAGGAGCUGAGCGCCAGCUCCCGCCAGCAGGAAUUGCACGCGCCUGGCCCAGGGCUGCCACUCUGGCUGCAAACUCAGUUUCUGUGACUUCAGUCCCUCUCUGGUGUCUGUAUUCCAUUAGCCUGGCCUCUUCCCUGAUGCAUCCCAAGACAGAUGCUGCCUUGCUCUCGCCUGUCCCUUCUCAACAAACGAGGGGCUGCUUCUACCCUUGUCUGGACUUCUGAAUAUUACUGACCCCUGUGGGCUACCCUCUGUAGAGAAAUCCAGCUGAUCCCUCCUACCCGGUGACCAGAAUCUACUGCGUCCUGCGGAUACAGGGGCCAUCCUCCAGACAAUCUCUGUUGUCAGCGCCAGAAGCCGGAACAGGUCCCCCAGCACCUCCCCUGCCUCGGUGAGCAGCGUGUGGGUCUGGCCCUGGCCUCUGCCUGCACGCCGCAUGUUUGACCACACAGGCACCUGCCUCGGGGUUACCAGCAAUGUUUCCAAGCCCCAAGAAACACUGUGAGAUAACCCACUCUUACUAAAUAAAAUGACAGCCUUGGUGAGCAAUAGGUCCUUUGGGCAAAGCAGAAUGAAAUCUCCAGUCUCUAAUACAAACAUGCACCCUGGGCAGUCACCCACACCCUUCAUACCGGCGUUCACUUCAAUAGCCGCUCGAAGGUCUUUUCUUUCCUUGCGGAGCUGGGCCAGCCUAUUCCGCAGGGCCUCUUUCCUCUUCAGCAGCUCCUCCUCUUUGGUCUGUAGCCGCUUGGCAUCUGCUUCUACCCGGUUCUUGCCAUACUUGUACUGGGCAGCAUCUUGAGAAGAAAAAAAAGCAGCAAUUAAAAAUUAGGUUUACUAGCCUGGGAAAUAUGGGACGAUCCCUUCUCCACAAAAAAUACAAAAUUAGCCAGGCAUGGCGGCACAUGCCUAUAGUCCCAGCUACUCAGGAAGCUGAGGUGGGAGAAUCGCUUGAGCUUGGGAGCUUGAGGCUGCAGUGAGCUGUGAUCCUGCCACUGUGCUCCAGCCUGGAUGACAGUGAGACCCCGUGUCAAAAAAAAAUUAGGUUUAUUCAAGCAGAUAAUGGGGUAACUCAAAAAGCCUGUUGAAUCAGCCAACUCAGUAAACAAACACAAAGCAUUAUUUUGCUAAUUCAACAAGAAAAGGACAGGGCUGGUAUGAACCAAGCAGAAAAGUGACUAGUUCAAAUUCUCCAAUAUUCUUUGAAUCAAAUUCUUAAAAACGAAAACAGAAUAUUAGGAAAUUCCUUUAAUUCACUUCCCUUUGAGGCACACGGCUUAUAAUUAAUCUGCAACAAGGUGGAGAAUGAACAUUCUAUAAUCGGAAAAGACAGGAGUAAUAUCAAAAAUAAUGUCUGAAAUUUGCUUCCUUCUCUACGUCUUCAAAUCCUUCCCUAACACCGCAGUAUCUGUUCCUUAUGGCCAUGUCAUCUGACUGGCUCUGAAUUGCUGCUACACCCCCAGCACUGAGAUUAGCACCCGGCACGGAGUGUGGCACAAUAAAUGCUUGUUUAGUGAAUAAAUGAACAACGGAUACAUGAAGAGGCAACCAGGAGCGGUAUCUGGAGCCUGACUGUCUAGGAAGGAGUCCCAGCUUACACUUGUAGCUGCAUGACCUGGAACAGGGCACGAAUCCCUCUGUGCCUCAGUUUCCCUCAUCCGUGAAAUGGGGAUAGUAAGAGCAGGCAAUUCACUGAGUGGUUACGAGGAUUAAAUAUUUAUAAAGCACUUAGAACAAACACAAAUGGGCAACACAUAAAUGCUUAUUUCAUAAAAUGAAUAAAUGAAGAGGAAACUAGCUGUAGGGAAAAUUUACAGACUUGGCAACUUCACAUCACCAGUGAAAACAGCUUUCAAAACCUGACCCCAUGCUCUCUCCUAUUAUGUUGGCUUUUCAAUAACAGUAAUUUAGGACAACACCUCUUUGUUAAGACACAUGGAAGAGAUGAAGGUUCUAACAAAACUCGGAUGGAGGAUCACCGAUUUCAAAGCUUCCGUGGUCUCCCAGUCGCUUCUAACAAUCACUCACGCCUGAAGGCAACUCCCAGGCCUUCCUGACUGCACACCCCAAGUGUCUGACUCCCUCACAAGGCUAGAAACUACUUCAGGUAGAAGCCACAGGGGUGGCAUAAUGAUUAAGAAUAAAAACACUGGACUCAGAGAGGUGGCUAGAAACCCACACUCCACCCUCCCUUGCUCCAUGACUCUGCAAGCAACCUCCGGAGAAGCUCAGCUUCACCCUCUCUAAAGCAGAAACGAGAAGGAAUCCUGUGUGUGUGUAUGUGUGUGUGCGUGCGUGUGCAUGCGUGUUUUAAAUUAGAACGUUAUAUCUGAAAAAAAUCUAACAAAAUGAUACGACGCCUGAUGUAGUGGACAUUCACUGACAAUUCUUACCAUAUCAGCGAUAAGUGAUUCCCAGAGCCUUGUCCACUCAGGGACAGCAGGGAGCCAUUUCUAGCACCUGUCCUAAAUGCUGGAUUUGCCAAUUCUUGCAACGUAAGUUAUCAUGAUUUCAAUGAAAUACUGCAUUUAUGAAGGCAUAAAAAGUGAUCACUCCCCAGUCAAUUUUCCCCUAAUCAAAAGAACCACAUAGAAUGACAGCAAAAGCGUCGGCAGCCUGAGGAGAGGCGAAGCAUUCGACAAUCUGAAACAAAAGGAUCGCUGUUUGCAGCUAAGGUUAACAACAUAUUUGGCAAACAGGGCCAAGUCCAAACUCUACUCGCUUAUUUCUAAACUAAGCUGUUUCCCCAAUGAACUCAAUGCAAUCACCUAUAAAUUUCCACAUCUUUUGGUCCCCAUGUAAUAAAUCCCAUCUAAUCUAUAAUGCAACCGGCUGGAUUCAAGCAAAAACACGGAAUGCCAUUAUUUUUCUCUUUUGUCACCAUUAGACGUCACCACAGUUAAUAAAAACUCCCUACAGAACAUCCCAUAAAAUAAAGGAAUAAAUCAUCUAGGAAAUAAAGUCAGCACAGGUACUGACAGAGAAACACCAUGGCGAUUGAGACUCCGUGGGACUCCGAUUUUGCUUGUAACAAAGCUUUCCAGGUGUGAGCUGCUCCUCUCCCCCAUCUGCCCCUCCUCAAAGAAACAACACUAAAAGAGGUGAAAGUAAAUACACCUGAUACAUUCAGGAAAUAAGAUUUGCCAGAUAAGGUCAAAGGAAGUUAGUACAUUAAACAAAUGGUGGUAGGAGGGAGGAUUUGGCCCAACUGGCUCCAACCUAUCUGGUCAACACGUAUGUUGGGUAGAACAGAGGUGGAGAAAAGCCUAGAUCAGGGAUGUAUACGCUUCCUUGGGGCAGACGCAGCCUGGCCCUGCGGAGCGAUUUCAAGCCUCGUUCACGAACAUGGCCAAGGACACUGCCAGCCUCUUCAUUCCCCUGUGUGGAUGCUCCAACUCCAAAAGUGGAACCACAGGGCAAAUGAAUGUCGGCACGUGUCGGUAUGGCAGCCUCGCUCUUCGACAGCUGGUGUGGGGGUUACCACCUGGGGCUAGCUGGCCUCAUCUUCGUUAGCACUGAGACUGGUCUACCAGUUGCACAGAUUCAGAUUUGAAAAUCUCAGGUGCAAAUCCCAAGUGGCGAUGGCAUGUAACCACAUCAAACUCAACAUCUGCACCUAACUCCCACCUUCUUUCUCUGGGAAAUCUUCCUGGACAUGCCCAGAUGGACUCAGGAGCCCAUCACCUGUAAAUCCCCACACUGCAGCCCUGCCACUUGCUUGUCUGCAUGUGUGGGUCCGCUGGACCACUUUGGUGUAUCUUUGAGCCCCUUGAGUGAAAAAAUGCUGCCUGGCUGGCUCCCUGAUUAGACAUCCAACAUAAUGAGGACUAACACCAAUACAAACACUUAAGAGAUGACAUAUCGCCCUAGCUGGAUCUACUACAGGGAAGGGAAGAGGGUGCUGGGUCCAGGCAGGCUGAGUGUCUCAUGUCUUAAUGCUUCUCUGCCCAAUCUAUUUCCGGCUGGAUGUGGAGUCUGAAGGCCUGGCACCCACUCUGGCUCUGUGAUUUACCAGCUGUGAGCCUUGGGGGAGCUGCUUACUCUCUUGGUGAUUCUUUUCUCAUUUCUAUGAUGGGGUAGAGGAUAAUGCCUAUGCUUACAAAGUGGCUGUGGGAAGUAAACCGGAUGGGAUAAGAAUGGCUUGCUGUGGACCACAGGCACCGCAGGAUAACCAUUCCUCAGAACUCCUCAUACUGCUCUAGUGCUUGGAGGUCCGUGUAUUACCUCAGCUAUUCCAACCGCACCAACCACGGGAGCCACGUGUCUACGUCUGACAGAUAAAGAUGCUGAGUUUAGAGUCUGCAAGGCUUGACAACCACAGAUCAGGGACAGGAGCUGAGGUCUCCUGACCUGGAGCCCAGGGCCACCCGGAGCUGCAAGAAACCUGCACUCACAACUGCCUCCUAUUUUAAAAUGCUGAGUCGAUCCCACAGGUGGCAAACCAGUUCUGGGCUUCAAUUUACAAGCAGUCAGAAAAGCUGGGUUGAAAUCGCCACUGUCCUUCUAUGUGGCUGAUGAGGAAGGAUGACGGUGCCCACCGCUCCAUCUCUCCAGCUGACCCCAAGCUGGCACUCACGGGUGGGCAGGCUCAGACAGGCCCAGCUCCACCAAGUGCACUUGAAGCCGGAAUGCAAGACAUCCGAUGGUAUACUUACUCGAACCCGUCCUUUUCACAACAGCCGCGGGAUCCGCUUUCUUUGGCUGACUGCUCAGAGUCUUCCCUUUUCCUGUGACCCCAUUAGACGCCACGGGGGGCUUUUUACCCUUGAGCUGUUGAAAUAAACAUAUAAGAACAUUAAAAAUAAACACAAAGUCAAACAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications