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Homo sapiens (human) FGD5 antisense RNA 1 (FGD5-AS1) URS000075E0BE_9606

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FGD5-AS1: FGD5-AS1 is a long non-coding RNA (lncRNA) that has been found to be upregulated in tumor samples compared to non-tumor gastric tissues [PMC7432170]. It has been suggested that measuring the level of FGD5-AS1 in blood can improve the early diagnosis of type 2 diabetes mellitus (T2DM) and the prediction of cardiovascular diseases (CVDs) in T2DM patients [PMC8796623]. FGD5-AS1 has also been found to be downregulated in gingival samples from patients with chronic periodontal disease compared to healthy samples [PMC7307862]. It is involved in the activation of the Wnt/β-catenin signaling pathway during Chlamydia trachomatis infection [PMC8460124]. FGD5-AS1 has been shown to enhance osteosarcoma cell proliferation and migration [PMC8588622]. It can also attenuate apoptosis and calcification of high glucose-treated human aortic vascular smooth muscle cells (HA-VSMCs) [PMC8796623]. Additionally, FGD5-AS1 has been reported to regulate oral squamous cell carcinoma progression by interacting with the miR-520b/USP21 axis [PMC7591988]. It is involved in gastric cancer cell proliferation, chemoresistance, and tumorigenicity through the Hsa-miR-1533p/CITED2 signaling axis [PMC9208527]. Furthermore, FGD5-AS1 downregulation suppresses cancer cell proliferation, chemoresistance, and tumorigenicity in various cancer types including pancreatic cancer, colorectal cancer, hepatocellular carcinoma (HCC), and non-small cell lung cancer (NSCLC) [PMC7432170] [PMC8166233] [PMC8611415]  [PMC7887693]. However, the role of FGD5-AS1 in gastric cancer needs further investigation [PMC9208527]. FGD5-AS1 has also been found to have potential functions in renal disease and may affect the survival of patients with renal disease [PMC7503457].

Genome locations

Gene Ontology annotations

Sequence

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AAUUAGCCAGCCCAUCCGUCGCUCACGAGGUCGCGCCUCGCACCCGCCUUCCUCCUUUUCUUUUACCCUCCCCUUCAGAAAAAACGGCGGUUGGGCUGCGACGGCCGCCAAAGGCGGACUAGAAGCGGAGGGGUGAAAAUCCCGGCAGAGAAGGAAGAAGGGACUGCAGGCGGGAGGAGGAGGAGGAUAAGGAGGAAGGGAGCCCGCCCAGCCGGAGCCAUCUCCGUCGAGAACAAAAUGGCGGCGCUGGCGGAGGGCCAACUAUAAGGCGGGGCCGCGGCCAUUCCCCCUCCACCCCCACCCUUGCGCCGGCCGGGCCGGUCAGGGGGAACCCGCUCGCUUCGCCCGGCCGCGGGCGGGGAGGGGAGGGGAGCGGCCCGGCCCACUAUGCAAAGCGCCGGGCGCCGCCGCCGCCACCCCGUGGCAAAGAAUAUGCUUUUUGUCUAAUGAUGUUAGAUAAAAAGCAAAUUUGGAGCAGUUUUCUUAUUCGAGUUCAAAAUGGUUCAUAAAGCAGCGAAGACAACUCAAAACAUCAGUAACACAUUUGGCCCAGGAACUGCUAACAAACAUACAGUGCAGUGGUGGCUUAAGAAGUUUUGCAAGGAAGAGAGCCUUGAAGAUGAGGAACGUGAUAUGGGCCAUGGGAAGUUGACAACGACCAAUUGAGAGCAAUCAUUGAACUACAUGAAAAAUUACAGAAGAACUCAGCGUUGACUAUUCUACGGUCAUUAGGGUCGUUCAGCAUUCGAAGCAAAUUGGAAAGGUGAAAAAGCUUGAUAAGUGGGUGCCUCAUGAGCUGAGCGGAAAUCAAAACUAUCGUUUUGAAGUGUAGUCUUCUUUUAUGCUACGCAACAACAAACCAUUUCUCAAUCGGAUUGUGACAUGUAAUGAAAAGUGAAUUUUAUACAACAACCAGCUCAGUGGUUGGACCAAGAGGCAGCUCCAAAGCAGUUCCCAAAGCCAAACUUGCACCAAAAAAAAGGUCAUGGUCACUGUUCGGUGGUCUGCUGCCCAUCUGAUCCACUACAGUUUUCUGAAUCCUGGUGAAACCAUUACAUCUGAGAAGUAUGCUCAGCAAAUUGGUAAGAUGCACCGAAAACUGCAAUACCUGCUGCCUGCAUUGGUCAACAGAAAGGGCCCAAUUCUUCUCCACGACAACACCUGACUGCGUGUCGCACAACCAGUGCUUCAAAAGUUGAAGGAAUUGGGCUACAAAGUUUUGCCUCAUCCACCAUAUUCACCUGACCUUUCGCCAACUGACUACCACUUCUGCUAGCAUCUUGACAACUUUUUGCAGGGAAAACACUUCAGCAUGGUGCAGAAAAUGCUUUCCAAGAGUUCGUCAAAUCCUGAAGCACGGAUUUUUAUGCUACAGGAAUAAACAAACAUUUCUCAUUGGCAAAAAUGUGUUGAUUGUAAUGGUUCCUGUUUUGAUUAAUAGAAUAUGUUUUAGCGUAGUUACAAUGAUUUAAAAUUCGCAGUCUGGAAAUUUAAUUUUUGCAUCAACCUAAUAUUUCUAUGGUAAAUCCUUGCAAACAUGGAAACAAUGCAUUUGGCCCAGUGCUUUGUGGUUGUGUACUCUUUUUCUUUGUUUUUUUAAUAGAUGGCAUUGGCCGGGCAUGGUGGCUCAUGCCUGUAAUCCCAGCAUUUUGGGAAGGUGAGGUGGGUGGAUCACCUGAGGUCAGGAGUUCAAGACCAGCCUGACUAACAUGGUAAAACCCCAUCUCUACUAAAAAUACAAAAAAAUUAGCUAGGCGGGGUGGCGGGCAUCUAAUUCCAGCUACUUCAUGAGGCUGCGACAGGAGAAUCAUUUGAACUCGGGAGGCAGAGGUUGCAGUGAGCCGAGAUCACACCAUUGCACUCCAGCCUGGGCGAUGAGCGAAACUGUCUCAAAAAAAAAAAAAGUUGGGGUCUCGCUGUGUUGACCAGGCUGGUCUCGAACUCCUGGCCUCAAGUGAUCCUCCCAUCUUGGCCUCCCAAAGUGUUAGGAUUACAGGCGUGAGCCACCACACCCUGCCUGGUUGUGUACUCUUUUAAAUACUAAGUUUUUAAUGUUAAAUGCUGCUUUUAGAUACACUGUAAAAAUACACCUAUCAAUGAGUUUUUUUAUUAAAAACAUUGCAAUUGUACUAGACUUUAAAUACUAAGCAAUAAUUCAGGCUUCAAUGUUGGUUUAUAGUUUUCUCAUUUCUUUCAUUUAAUACCUCUGUAAAAUGAAGCAGUUACUUCCAUUUUCCUGAGGUGAGAUAAGUGCCCUGCACAAUGUUAUAGGCCCAGUAAGUGAGACUGGAGCUCUGAUCUAAUCCCUUUGACAUUAAAGUUUGUGCAGUAAACCAGCUAUGUCAGUUUGCCACAUUUGUAAUAGUGUUCAAUAAAUUUUCACUUAAAGGUUUAAUAUUAAAGUAGUAGCAAGAAUUCAUAACCUUAAUUGGCUUUAACAGCUUUUCUUUCCCUGAAAACAGAUGCAUAUGUACACAUGCACACAGAUUGCUUACAAUAUCAGCACGUAAAAGGCCUUUGCACAUUGAAGUCGGCACUGCUUUGGUGCCUUUUUUGUUUUUUGGCUCGGUGUUUUGACUGCAAGUCUUUUUGGAUAGAAUUUUAUAGUUAGAAAGUAGCUAACACUUGGGUUUUAUAGGCACAAAAAACAAGUCUUAUACUAGCUGUACUUUAUUUUUUGAGUUCUUAUUAAUGAGGAACAUCCACUUUUGCAUUGACAGUGAUUUCAAGAUUGCUUUAUCAGCCUUUAAAGGAUUCUUGACUAGUCGUGCACAUCAGAACUGCCAGGUCCCCAGUGGUUCUGAAGCAGUAAGCUUUGGGUGGGCUCUGGCAUCAGCACUUUCACUAAGCUUCACAGAUAAUUCUGAUGCAUACUCCAGGCCUGAACCACUGAUCAAUUUGAAACAUGCAUAACAAAGCAAAAAAAGUUUUGUUUCACCUUUUGAAAUACAGUUAACUCUUUUACCAUGCCAGAGAUCAUUCAGAGAGACAGGUCGUUGCUCCGGAGUGAUACAGAUCUGGCAGUACCCAGCCCUUGUGUGUGUGCGUUAGCUCAGCACCUGCCCACACUGCGAGCCCCCGUAGGAUGUGCCUUGUCCUUCCCUGUUUCAGCACUUAACACACUACCUGGUACAGAGUAUGUAGUGGGCAUCUGUUGAAUGAAUGCUUUUCCCAGUAGCAGUGUAUUCAUACAAUAUUAAUAUAAUUGUCCCCUGGCUUACAGAUAAAAAUGAAAGCAUCAAGUGCCCAGUGAGUGAGACCCAGGUGUUCUUCCUCCACCCCUAGUGGUCCCCUGGGCAGGUCUUUUUUUUUUUGUAACACUCACCAGUCUGUUCUGUAGUCAAUCAUUGAUUGACUUGUCUGUGAACUUGGAGGAACUGUUUCAUAGUUUCAUUAGCACAGAGUAAACAUGUUUGCCAUGCAAGGUUAUUUUGCAUCUGCAUUUAAGUGAUAAUGUUGAAUCAAUGAAAAGUGUUGAUUAAGCAGUAGUUGUAGAUAUGCUAAGUUUUUCAAAUUACUAAUAUCAAGUGGAGAUUGUUUUUACUUUUAAGGGUAUUGCUUUUGUGAUAGCAUAAAUAAUGGUUUUCCUUUUUUGUAAUGUAAAUUAAUUGCUGGCAACUUUUGUAUUCCCAUAGACUGGGGAAGCUUAAUUGCCUUUACAAGUACUUAUGUACAACUUUGUAUCAAAUUUUCUGUAAUAGUUUAUGCUUUAGUACUAUAUAUGUACUAAUAAUUUUAUCUGACUUCUGUUUAUAUCAUUUGUACAAUUACAUGGUUGUAAAAUAAACUUUUAAACCUCACGUAA

Taxonomic tree

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Publications