MIR506: MIR506 is a microRNA that is upregulated in the intrahepatic bile duct of patients with primary biliary cholangitis (PBC) and regulates the secretion of biliary epithelial cells (BECs) by targeting AE2 [PMC8147992]. However, a specific interaction between endogenously expressed miR124 and MIR506 does not account for the decrease in expression level in astrocytic cells [PMC5476465]. In pancreatic ductal adenocarcinoma (PDAC), the replacement of MIR506 induces autophagy [PMC9312874]. Overexpression of MIR506 leads to an increase in BCL2 gene expression [PMC7477680]. Low expression levels of MIR506 may contribute to higher levels of CDK6 and CTNNB1 mRNAs in adrenocortical carcinomas (ACCs) [PMC5764399]. MIR506 is part of a group of noncoding RNAs, including miR-34, miR-155, and miR-21, that regulate the reactive oxygen species-cancer axis in various malignancies, including lung cancer [PMC9442502]. In T-cell acute lymphoblastic leukemia (TALL), transfection with MIR506 leads to an increase in its own expression [PMC7477680]. In wheat, 58 miRNAs have been discovered, including MIR506, which targets AB182944 encoding a knox1b homeobox protein [PMC5360763]. Finally, PCR analysis using specific primers reveals binding sites for SOX9 and TEAD1 on the promoters of SOX9 and MIR506 genes respectively [PMC6756096].