NFIA-AS1: NFIA-AS1 is a long non-coding RNA (lncRNA) located on chromosome 1p31.3 [PMC10089782]. It has been shown to be involved in the regulation of atherosclerosis (AS) through the miR-125a-3p/AKT1 axis [PMC10089782]. Knockdown (KD) of NFIA-AS1 in oxidized low-density lipoprotein (Ox-LDL)-induced vascular smooth muscle cells (VSMCs) reduced the expression of inflammatory and adhesion factors, suggesting its role in regulating inflammation in AS [PMC10089782]. NFIA-AS1 was found to be highly expressed in Ox-LDL-induced VSMCs and AS tissues, and its overexpression promoted AKT1 expression by sponging miR-125a-3p, thereby promoting VSMC growth and inflammation [PMC10089782]. NFIA-AS1 KD improved AS symptoms in mice, as evidenced by reduced levels of inflammatory cytokines [PMC10089782]. The targeting relationship between NFIA-AS1 and miR-125a-3p was confirmed through luciferase reporter assays [PMC10089782]. Furthermore, NFIA-AS1 KD inhibited VSMC growth, migration, invasion, and promoted apoptosis induced by Ox-LDL [PMC10089782]. The correlation between NFIA-AS1 and AS was analyzed using the LncBook database [PMC10089782]. This study is the first to elucidate the involvement of NFIA-AS1 in regulating AS through the miR125a3p/AKT axis [PMC10089782]. References: [PMC10089782] Liang Y et al. LncRNA-NFIA antisense RNA 1 negatively regulates ox-LDL-induced inflammation via targeting miR125a3p/AKT axis. J Cell Mol Med. 2020;24(24):14461-14473. doi:10.1111/jcmm.15661