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Homo sapiens (human) MRPL23 antisense RNA 1 (MRPL23-AS1) URS000075DE97_9606

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MRPL23-AS1: MRPL23-AS1 is a long non-coding RNA (lncRNA) that has been found to play a role in tumor progression in osteosarcoma (OS) [PMC8806645]. The invasive ability of 143B cells was significantly increased when MRPL23-AS1 was ectopically expressed, as shown in Figure 2(d) [PMC8806232]. Conversely, silencing MRPL23-AS1 in U2OS cells resulted in a significant weakening of their invasive ability, as shown in Figure 2(e) [PMC8806232]. These findings suggest that MRPL23-AS1 promotes tumor progression and is involved in the invasive behavior of OS cells. Additionally, the overexpression of MRPL23-AS1 led to an enhanced malignant phenotype, which was effectively blocked by ectopic expression of miR-30b [PMC8806232]. This indicates that miR-30b acts as a tumor-inhibiting factor and suggests that the deregulation of the MRPL23-AS1/miR-30b axis may be responsible for OS growth and spread. Overall, these findings highlight the significance of MRPL23-AS1 and its interaction with miR-30b in osteosarcoma progression.

Genome locations

Gene Ontology annotations

Sequence

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GGUGGCAGCAUGGCCUGGGGGUCCUGGCACCGCUGCUCCUCUGCCCACCCUAACUUCCCGGCAUGGCGGCUGCCCCCUCUGAGCGUCCCCAACCAAACUGCAGGGGAUAUGAAGCAAGCUGGACUUGGGGAGACAUCUCUGCUCGAGUGCACGUUGGCCUGAUGACGACUGCUCUUGGGUUCACGGGUUCCAGGCUCUGCCCGGGAGCCUCAUGCAAACUGGUCCCGUUCUACAGACGAGGAAACUGAGGCACAGAGUGAUUACGGCUGUCCCUGAGCUCCUGCAGCCAGUAAGUGUCUCUGAGGAUGAACUGCCAUGUGCCCGGCGGGGAUGCCGUCCCUGGCCCUUGCUGAGUGCCUCUGGGACGAGGUCAGCUGAGCCUGCCAUCCUAACUCAGACACCAUCUCACUCUCCAAGUCCCUUCUCGGCCCAGCAAAUUCUCACCUCCAGAGGCCAGGUCUGCCCCGCAGGUCUUAGGAAAUACAGCCCUACUUCCAUCCAGCACACCAACCCAAGGAAGUGCCUCGGAGCCCUGGGGCCCGAGGGGGGCCUGGCCUUGGUCUCACGGCGGCAGCUCCACCUGGAGAGGAGUGAACUCAAGCCAGGACGCCCCGUCUCCACAGCGGAAACCGUGUUGCCGGCUGCUCCCUCCUGGGGACUCUGGGCCUGAGGUUCCUGUGGGAGUUGGGGGGAUAGCUGAGUCCUAUGGAGGUGCCCCUCUCCUCCCCGCCCAGUGGAGCUUGGGGUGGGGACAGGCGAAGACAGGGUGAGAAGCACGGGGCAUUCCCCCUCCACACAGCGCUGAGAAAGUAAGGGAGCAUCCAGAAAACGGUGCCCACUUCCGCGUCAGGCGGAUAUCACGGGCACCAGCUCCAGGUGACCCUAGCCCAGCCAGAGAACAAGGACCAGGUUGUGCCGCAAAGCCCGUGUCCGCUCCCUCCCGCCUGGGACCACUGUGGCGAGGGGAAGGGAGCGUGGUGGCCCUCUCCUGACUCCUGAGGCCUGAAGUCCAAGCUCCCGGCCCUCAGGCAGGCCAGGGUCUAGACACCGCUGCCCCAAACACACCCCCCAGUCCCCGCCCGCAGGCUUCCUGCAGGAUCCCCCAGUGCACCUGGGGGCUGAGGAGAGUGAGCAGGGCGCAAAGAAGCUUCGUCGGGAGGGCGGUCCCCACCCGCCUUGGACCCCCGGGGAUAGUGUCCUGGGGCCUGGGCUCAGAUGCACCCUGGGAGGAAUGGUGCGGAGGCUGUUUUUUGCUCCAAGAGGACAUUGCCUCAGCAGAGGGCUGCCGAGCUGGGAGGACCCACAGUGCAAGGCCGCAGAACCCCCUAGGAAGCCUCAGAGCCUUCAGGUUCCGGGCUGAGGCUGUGGGCGUGGACCCUUGUGCAAACCCCACUGGAAGAAAAACCUUACAGCUCAGGAGGAGGAGGGGCCCCACCCGCUCCCAGAGCCCGUAAACGAGGGGUGGUGCCCACAUGAGGCCUGGGGAAGGGCUGGGGCUGGGACACCCCCUCACCACCCCCAGAUACCCCAGGCAGCCCCUCCCUCCACAGAGAGACCCACUGGGCCUGACCCUGCCCUGGGCACAGGGUCGAGCCAGGGACGGCCCGUGGGAGAAAGACGGCUUCAUGGGCCGCUGGCCGGGCCAGGUGCGUCCUUCCCCAGUUCUAGGUGGCAAAUGGGGUGGGGCCAGAGCCUUCUGGCUAGGGAAGACACUGGCCUGGUUGGUGUGGCAGGGGCAGCGAAGGAGGGUCAAAGGCCACUCUGGCCUGGAAGAGUCCCCAGCCACCUGGACGGGGGUAGCCAGGCCUGGUCCCUGCCCCCACUCUCCAAGGGGUCGGGGCAGCCGGGCAGAGCCAGUAAGUGUUUGUUUUCAGAUGACAUUUGUAAAGAAAAACAGCCUCCCA

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Publications