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Homo sapiens (human) small nucleolar RNA host gene 16 (SNHG16) URS000075DE45_9606

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SNHG16: SNHG16 is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases, including neurotoxicity, cancer, and alcohol use disorder (AUD) [PMC9823062] [PMC7874551] [PMC8573238] [PMC9992383] [PMC9270258]. In the context of neurotoxicity, overexpression of SNHG16 has been shown to inhibit bupivacaine-induced neurotoxicity by regulating downstream miR-132-3p [PMC9823062]. In glioma cells, SNHG16 is downregulated by ropivacaine treatment and its overexpression reverses the effects of ropivacaine on cell proliferation, apoptosis, migration, and invasion [PMC7874551]. SNHG16 has also been implicated in breast cancer as a regulator of CD73 expression on Treg cells and a potential target for immunosuppression in the tumor microenvironment [PMC9238168] [PMC8788502]. Furthermore, SNHG16 has been associated with catecholamine metabolism and FGF21 concentrations in the context of alcohol response phenotypes and AUD treatment potential [PMC9270258]. In melanoma cells, knockdown of SNHG16 leads to decreased migration and invasion abilities [PMC9379127]. Additionally, exosomes derived from breast cancer cells can deliver SNHG16 to induce CD73 expression on Treg cells in breast cancer samples from Chinese patients as well as regulate CD73 expression on γδT cells in breast cancer tumor microenvironments through various pathways involving miRNAs such as miR-16-5p or miR-195/SREBP2 axis or TGF-β1/SMAD5 pathway respectively  [PMC9992383] [ [PMCID: PMC10045733][PMCID: PMC8247393][PMCID: PMC7261328][PMCID: PMC7816309][PMCID: PMC8072401]. Overall, SNHG16 plays a critical role in various biological processes and diseases, making it a potential target for therapeutic interventions.

Genome locations

Gene Ontology annotations

Sequence

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GCGUUCUUUUCGAGGUCGGCCGCGUGGCUGGAAGACAUGGCCACUCCAGUCGGUGUUGAGCACGGCGAGCAGUCUCAGGCCUUUAGUGAUGAUGAUUAAAGGUGGUGGCUGUGGCCUUGAAAACAGUCAUGUGAAAACUCAUCACCUUAAGGUGUUAAGUGUAAGGAUCUUCAUGAUGAAAUUUCUGUAAAUGGUGCAGUCAGCCUCAGUUUCCAAAGCCGGAAAAGGAUCCUCUAGUAGCCACGGUGUGGCAGCUGCUCUGAACCAGGACCUGGACCCGGACCCAAAGUGCCAUGUCUUUAAUGUGAGUUAGCUCCCAGCGAUGCCAGAUGGGAUCAGCACAGCCCUGCCUCUGCUGCUAAUUGUUCCUCUAAAGUAAUCGCCAUGCGUUCUUUGGGCUUCAUCUUUAAAGGAAUGAAGCAACUGAGAUUAUUCUGGAAAACCUUUUGGCAGUUAGUGAAAUUAGAGUACAACUAAGAACAUUUUCAGACCUCCACUGUGGAUGACCUGGGUAUAAUCUCACAAAUCGAUGGGACUGCAAGGAUUGUAAACUGAAAUGAACAUGAUUAUACUCUGUUGGAAGAGCCUAAGAGGAAACUGAUGCCAUGAGUUUCAGAGAGUAAUGCUUAACCCCAGUUACACAGGAUGCCGUCUUGUGUUUCCUCUUGUUUAGUUACCCACUACAGUGAUUUUGUGAUCUGCUAAUGGGUUGCCACCCACAACCAUUGCUUUAGCACUUUUACUUCAAAUCAAUGAAGGAUUGAUAAAAGUUCUCCUGGUGUCUCCGCAGAGUGCCUUCCAGGAACAGAUCUUUGCAUAGAAUAUCAGUGGUUUCCUUUUUUGUUUCAAAUAGUGGUCAGAAAAUACCCAGUGUUGACUCACCAAGGCAAUCAGCUUCCUUUUUCCCUUUUUUUGUUUUUUUUUUAACAUUUUAUAUUUUUGCUUUAUUUUAUUUUAUUUUAUUUUAUUUUAUUUUAUUUUAUUUUAUUUUUUGAGACGGAGUUCCACUCUGUCGCCAGGCUGGAGUGAAGUGGUACAAUCUUGGCUCACUGCAACCUCCACCUCCCGGGUUCAAGCAAUUCUCCUGGCUCAGCCUCCUGAGUGCUGGGACUACAGGCGCGUACCUUCUUUAGUAGAGACUGGGUUUCACCAUGUUGGCCAGGAUGGUCUCUAUCUCCUGACCUUGUGAUCUGCCUGCCUCAGCUUCCCAAAGUGCUGAGAUGACAGGUGUGAGCCAUCAGACCCAGCAUUUUUUUUUUUAAUUUAAAUUUAAAUUUUUUUUCAUUUUUUUGAGAGGUUUUUUUUGUUUUGUUUUGUUGUUGUUGUUGUUGUUGUUUUUGAGACAGUCUUGCUCUGUCACCCAGGCUGGGAGUGCAGUGGCAUGAUCUCUGCAACCUCUACCUCCCAGGUUCAAGCAAUUCUUGUGCCUCAGCCUCCCAAGUAACUGGGACUACAGGUGCACGCUACCACACCUGGCUGAUUUUUUUUGUUUUAGUAGAGACAGGGUUUCAACCAUGUUGCCCAGGUUGGUCUCAAACUCCUGAGCUCAGGCAAUCCACCCGCCUUGGCCUCCCAAAGUGCUAGGAUUACAGGUGUGAGCCACCACACCCAGCUAUUUUUUCUUUCGUUUUUUAAUUUUAAAGUUGGGGGGGGGUCUCAAUUUGUUACCCUGGCUGGUCUCGAACUCCCGGACUUAAGCGAUCCUCUGGCUCCAAGCCCACUACCAGUCUCAGGUUUCUUUACUAAAAGAUCACUACCUUUUUUUCUCUUAUCUGCUGCCAUGUGAGAUGUGGCUUUCACCUUCCGCCAUGAUUGUGAGGCCUUCCCAGCCAUGUAGAACUGUAAGUCCAAUAAACCUCUUUUGUAAAUUAAAAAAAAAAAAUCACUAUUUAAGAUACUAGGAUGGAUUGUGACUGUUGAGGAGUACUUACAUAUCCUACAUUUGACUACAUUAUUUCCAAACCAAGUAUUCCAUCCAAAGGAACAUACUGCUAUCAUAGAGACCAAGGAGGGACUGUUUAAGGUUGCCAAGGUGAAGCGAGCUGAGAGGCUUUGUCCUCGUGCCAGUAACUCUGAAAUCUCUCUUAAUUCCUGCUGUCCAGGCAGCAGAAUGCCAUGGUUUCCCCAAGUAGGUAGCUGCUUUAGCAGUUAAAGCCCAAAUGUCUGUUCUGUUGAUCAGAGGUCUCUGAAUUUCUGAAGUGGUGUUUCGUUUCUGGUGACUGAGUUAAUCCUUUACAAUCCCUCUUGUAAAGUGUGCUAAUAGAAAGAAUCCACCUUUCAAAGCUGCAGAACCAGACCGUGCCCUAAAUUGACCAACGUAACUGAUGUGCCUCAGGAAGUCUCUUGCCAGCUGUCCCUGUGAAGACCCCCCUCCUCCCCCCCAGCUGCUGCCUUGCACACUGAAGCAUCUCAGACUGUGCAAAGCCGUGUAGUCAUCAAGACAGUAAAUCCCAGGGCUUGGUUAAGUGCUGUGUGAUAACUUGUUUGGAUGAGACUUAACUUAAAACCACUUACAAUAAACUUGGGAAACUACCGUCA

Taxonomic tree

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Publications