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RNU5E-1: RNU5E-1 is a small nuclear RNA (snRNA) that has been studied in relation to hepatocellular carcinoma (HCC). Research has shown that the expression of snRNA RNU5E-1 is lower in HCC tissues compared to adjacent tissues [PMC9667552]. This finding suggests that RNU5E-1 may serve as a useful biomarker for predicting the diagnosis and prognosis of HCC patients [PMC9667552]. Furthermore, RNU5E-1 has been associated with various clinical characteristics of HCC, including tumor size, vascular tumor thrombus, differentiation degree, TNM staging, tumor recurrence, and long-term survival [PMC9667552]. In a recent study by Ding et al., it was suggested that RNU5E-1, along with SNORD31 and SNORA71A, could be used as prognostic genes for HCC [PMC9524901]. Additionally, RNU5E-1 is one of the highly represented transcripts in non-coding nucleolar and nuclear RNAs found in HCC cell lines [PMC5669939]. This indicates its potential importance in the molecular landscape of HCC. Overall, these findings highlight the significance of RNU5E-1 as a potential biomarker and prognostic gene for HCC.
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