v24

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Homo sapiens (human) long non-coding regulator of POU2F2 (LNROP) URS000075DBF1_9606

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LNROP: LNROP is predominantly present in the nucleus and is a direct target of MYC [PMC9971199]. Standard CRISPR-Cas9 was used to disrupt the sequence and function of LNROP [PMC9971199]. Disruption of LNROP downregulates pathways controlled by OCT2, such as the JAK/STAT3 signaling axis, type I IFN response, and genes regulated by NF-κB [PMC9971199]. Overexpression of LNROP using two different experimental approaches was investigated [PMC9971199]. SHP-1 was used as a downstream target gene to illustrate the reach of LNROP [PMC9971199]. The expression of both LNROP and OCT2 was reduced when analyzed by RT-qPCR [PMC9971199]. The genomic sequence of LNROP was retrieved from Gencode v25 and guides were designed to cover the whole locus, including introns [PMC9971199]. The disruption of LNROP downregulates OCT2, but not vice versa [PMC9971199]. Guides targeting LNROP caused a reduction in the expression of both LNROP and OCT2 [PMC9971199]. The expression levels were measured using RT-qPCR analysis [PMC9971199].

Genome locations

Gene Ontology annotations

Sequence

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GGAUAAGCAGGCUGGAAGAGCCGACUCCUACGGCUGCGAUCCAAGAGGUGCCUGCAACAGUUGCCCCCCGACUUCUGUCGCCCCCAUGGAGGCAAACAAGUCUGGAACAGGGAAUGGGGGUCUGGGAGAGAAGAUGAAAAGACUGAGGAUCAGAGAGGUGAGCAGUAGCUUUCCCAAAGGCCCAGAGCCAAGAAGCGUUGAAGCUUAAAAGCACGCCGCGGCAGGGAAGAUCAAGCAAGCCCUGCGCCUAUCUGCAGCUUGAUCUCUCUGUACUGAGCCAUGGAGCUCCUUCUUGGAGGCGUGAAAUGCUCCCCAUCCUUCAGGAGACAACAGCAACAGCCAGCCACUCCUUGUCCAGUCAGCAAUGCUGGAAUACCUCUGCAGCUCACAGUCCAACGCCCACAGCCUUCGAGUCAGUUUCUUGAUAUUCGGCAAUGCACUGGACUCCUGAUCCCAUCAGCUCCUGGCUGAAGGUGGGCCAACCCUUCCCCAUUUCCUUCAAUUCAAACAUUUCCUCAUGUCCCUCAGUGCCAAGCCCUGUGCUGGGAGCUGAGGACCCAGAGGUGAGCUAGAUCUAAAAUCUGACCUCAAGGAGCUAACAGUCUGAGAGGAAGACUGGAGUGGAUAAAAAUACCUUGGUAAUUUAUCACUUAAUAAAUAUCCAAUAAAUGCUAUUAUGUGCCAAAAAAAAAAAAAAAAAA

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Publications