LINC00709: LINC00709 is a long noncoding RNA (lncRNA) gene that belongs to the category of lncRNAs with important regulatory functions in the expression of multiple genes [PMC6587859]. In a study of patients with no family history of colorectal cancer (CRC), the LINC00709 rs10795668 and rs11255841 variants were associated with a lower risk of colorectal adenomas [PMC6587859]. These variants maintained statistically significant associations even after Bonferroni correction [PMC6587859]. Additionally, the LINC00709 rs10795668 and rs11255841 variants were associated with a reduced risk of adenomas in patients with no family history of CRC [PMC6587859]. Other single nucleotide polymorphisms (SNPs) in LINC00709, as well as in CDH1, were also associated with a reduced risk of developing colorectal adenomas in patients without a family history of CRC [PMC6587859]. In contrast, an intergenic variant (rs4779584) was significantly associated with an increased risk of high-risk adenomas [PMC6587859]. Furthermore, the LINC00709 rs11255841 variant was significantly more frequent in first-degree relatives (FDRs) of patients with CRC who had low-risk adenomas [PMC7861964]. This variant is located in the LINC00709 gene at the 10p14 chromosomal region [PMC7861964]. In summary, specific variants in LINC00709, such as rs10795668 and rs11255841, are associated with a lower risk of colorectal adenomas and may play a role in early stages of CRC development regardless of family history [PMC6587859][PMC7861964]. These findings highlight the importance and potential regulatory functions of lncRNAs like LINC00709 in colorectal cancer development.