v24

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Homo sapiens (human) PEG3 antisense RNA 1 (PEG3-AS1) URS000075DAE7_9606

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PEG3-AS1: PEG3-AS1 is a long non-coding RNA (lncRNA) that has been identified as part of an 8-lncRNA signature in a recent study using a random survival forest method [PMC7068734]. This signature also includes LOC100505715, MINCR, DBH-AS1, LINC00664, FAM224A, LOC642852, and LINC00662 [PMC7068734]. PEG3-AS1 is involved in ceRNA axes along with two other differentially expressed lncRNAs and seven miRNAs [PMC9671706]. These axes also include eight key mRNAs (EGR1, ETV1, DUSP6, PLOD2, CD93, SERPINB9, ANGPTL4, TGFB2) and seven key miRNAs [PMC9671706]. PEG3-AS1 has been found to be correlated with acute myeloid leukemia (AML), colorectal cancer (CRC), and head and neck squamous cell carcinoma (HNSCC) [PMC9671706]. However, the exact function and mechanisms of PEG3-AS1 are still poorly understood [PMC9671706]. In a study investigating the correlation between PEG3-AS1 and schizophrenia (SCZ), it was found that this correlation was reported for the first time [PMC9671706]. In another investigation using RNA-seq data from The Cancer Genome Atlas (TCGA), the expression levels of several lncRNAs including PEG3-AS1 were analyzed in normal and papillary thyroid carcinoma (PTC) tissues. The downregulation of DIO2-AS1, LOC100130238, NCAM1-AS1, PEG3-AS1, BCDIN3D-AS1, PAX8-AS1 were observed in PTC tissues compared to normal tissues. However, LRP4-AS1 was upregulated in PTC tissues compared to normal tissues [PMC9095586]. Overall, PEG3-AS1 is a lncRNA that has been implicated in various diseases, but its exact role and mechanisms of action are still not fully understood. Further research is needed to confirm its association with schizophrenia and to elucidate its function in different diseases [PMC9671706][PMC9095586].

Genome locations

Gene Ontology annotations

Sequence

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AUUAAGUUAGCGAUAGAAAGAUCUAAGGAUACUAGCUCCUGGGCACCUAGGGUGCAAACUGACUUGUGGCAGCAUAAGCUGAUGCUGCACAGGGGACCCAAGCCAUGUUGCUACUUGUCACUUAAGGCAGGAAGCGCACAAAGGAAGUGAUGAAAGGUUAUUAGCCUGCAACAUUAUUUACAGCAUGAGAGCCUCUCCUACGGUUCUCAACCUUCAUUAGGCACUACUGUGAUCUAGUGAUGGUUGUAACCCAUUCUUUAAAGGCAAAGAUGUAAGAUUUACAGGGAAAAGCUUCGGGUUUUAUCAAUUCACUAUCAUCAAACACAUAUUGAGUUGGUUAAAAAAAAAAAAAACCCAGAACACAAAUGUGUAAUAUUUUUGCAUGAGAACCACUUCAACAAACAUAACAUGUGGCAACCAAUCAAUCUGGGUCACAAAAAGCCAAUCCGUAUAUUGUAAAGCCUUACACAGUAUUAGGUUCCAAAGUGUUGGCGCAGAUGAAAUGGCUGCAGAAAGAAGCUAAAGUACUUAUCUUUUCAAACAGUAAGGAGUAAAAGCCAUGUUAUCUAUCAUGCCUACAGCUUCACAAGACUAUUUAAGGGUAAGAAACAAAACAAUUACUCAAAAAGAUAUUGACAGGGUUCAAAUAAUGCACAAUAAAUCUUUCUCAGGAUCUAAGACACUUAAAAAUAUAAUCAAAUUUGUUGCUCUCUUCCUCCUCCAAAAAAAAAAAAAAUUCAAAGAAUACCAGGUAAGGUACCUCUGCAGAGUAAACUGUAACUGUAUAUCAUAUAAAUCCAAAUAUAUGUGAUCACUGUUCUGUCAUAAUUUGCUAUUUUAUAUACACCUCAUGAAACACUAUAUAUACGUUACACAAGUGUCAUUUACAGUUGAUUUGGGCAAACUCUGUAGUCUGGAAUACUCAUAGGGUUUUCUCAAUCUGAUUACUUGGAAAGGUAAGAUGUGUGCUAUGGCUUUCCCACAUGCAGACACUGACAUCUGAAGGGGAAAGCUUAAGACUGUGGAAUCUGCACAUUCGGUCUCUUUUCAAUCUGAGUUUAGAGAUGUUAAGUCAGGUGUGUAACACACUAAGGUUAAGUCUCCUACUGACAUUAUCAUGGAUUGGUUUGGAUUCUCUGUGGUUUGGUAAGGGUCAAGUCCUAGGUGAAGGUUUUCUAACCUUUACCCCAUGCCCUCAGCCAGUGUGGGUAUUCUGGUGUCUGGCGAGGGACAGGCGGUCAUUGAAGAGCUGCCCACAGACGUCACAUUUGAAGUACUUCUCAUCAGCUUGAUUGGCACCACCUGUGCUGGUGC

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Publications