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hsa-mir-580: Hsa-mir-580 is a microRNA that has been identified as one of the leading upregulated miRNAs in melanoma [PMC6820336]. It has been found to potentially modulate five out of ten hub genes, including DMRT2, MTCH1, MTERF4, NHS, and MMGT1 [PMC6820336]. Additionally, hsa-mir-580 has been associated with the pathogenesis and development of melanoma [PMC6820336]. It has been observed that rs5742714 creates a microRNA binding site for hsa-mir-580 [PMC6337782]. Hsa-mir-580 is predicted to pair with several miRNAs including hsa-miR-1208, hsa-miR-1257, hsa-miR-145, hsa-miR-198, hsa-miR-516b, hsa-mir-580, hsa-miR-587 and hsa-miR7 [PMC7545778]. The substitution of the rs5742714 G allele by the C allele may create an miRNA binding site for hsa-mir-580 in breast cancer and negatively regulate TWIST1 expression [PMC5157037].
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