v24

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Homo sapiens (human) long intergenic non-protein coding RNA 1300 (LINC01300) URS000075D86E_9606

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LINC01300: LINC01300 is a long intergenic non-coding RNA (lincRNA) that has been associated with reduced overall survival (OS) in certain cancers [PMC8101537]. In a study investigating hepatocellular carcinoma (HCC), LINC01300 was one of seven lincRNAs selected for further investigation due to its copy number variation (CNV) gain in more than 50% of HCC samples [PMC8101537]. LINC01300 was found in the blue module, along with LINC00608, and was associated with T and N stages in HCC [PMC6759597]. Additionally, LINC01300 was negatively correlated with CD8+ T lymphocytes and M1 macrophages, and positively correlated with tumor mutational burden (TMB) [PMC6759597]. The potential functions of LINC01300 were consistent with the blue module, which is involved in protein processing and presentation [PMC6759597]. In the context of head and neck squamous cell carcinoma (HNSCC), LINC01300 was also found to be associated with poor prognosis [PMC6759597]. Furthermore, a three-lncRNA panel for predicting overall survival in HNSCC patients included LINC01300 as one of the prognostic lncRNAs [PMC8717422]. Overall, these findings suggest that LINC01300 may play a role in cancer progression and could serve as a potential prognostic marker.

Genome locations

Gene Ontology annotations

Sequence

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GAGGUUUCAUCAUGCAGAUGAAGCCUCCAGGCAGCAGACUGCAGAGAGAAUGGAUGGGAGAUGUUUAUUAUCAGACUGAAAGACUGUUCUGCCAGUCAUUCCAAAAGGGAGGGGGGAUAACAAGCACGGUGGCUUCAGGUCCCUCCGCAUUAUCGCAUGUGCCAGUGCUUUGCUCCUUUUUACACCUGAGUAAUCGUCCACUGUGGAGUCAUCCUUUCAGCUGCUGAGAGAUGCGUGGGCAGUUUCCACCUGCAGCCAUCAAUUCACAAAUCCUACAAUUCUAAGCUCUCAGAACCCUUGGAUCUGAAGGUUCUCAAAUGCUAAGGUUUCUAGAUGUUAGCAGACGAAGGUGUCAAGACGCAUGGGAUCUACGAUGCAGAGUUCUGAGUGGGGAUAUGCGUCCCCCACCCCGACUCACCCCACGACACAUAUCAGUAACAGCCUCUGCAACUCCGCCUUGGUGCCCCCGCACGUUCCAGGGGCAGCCACACUGAUGGAUUGCUCAGAACGGGCUGGAGCCGCAUCUCCACUUCUGCCCCGACAGUUCCUGCUGCAGCAGAUGCCCUUCCAGAUGCAAACUCCUACGCAUCCUUCAAAACCCAGCUAAAUGUCACUUCCUCCGGAAAGCCUUCCCCACCUCUCUAGCAGGCAGUUGAGCCCAGCUUACAUUUCCGACAGGCCCUCACUGCCCGGGAUUGCAGCUGCGGGCUCCUUGAGGGCAGGGAUUGUCCCUCAUUCAUCCUGAUUCCAUGCCAAGGCUUAUAGUAGGUGCUCAAUAAAUGCUUGCUGAAUGAUAAAAAAAAAAAAAAA

Taxonomic tree

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Publications