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Homo sapiens (human) urothelial cancer associated 1 (UCA1) URS000075D6E2_9606

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UCA1: UCA1, a long non-coding RNA (lncRNA), has been shown to suppress the expression of miR-204-5p in chondrocytes [PMC5710923]. It has also been found to induce acquired tamoxifen resistance in MCF-7 cells through exosome-mediated transfer [PMC5610032]. UCA1 has been implicated in the invasion and migration of osteosarcoma cells, as well as the modulation of gefitinib resistance in non-small cell lung cancer (NSCLC) [PMC6463206, PMC8632870]. Knockdown of UCA1 has been shown to inhibit the tumorigenicity of renal cancer cells [PMC6988374]. UCA1 has also been found to interact with itself in osteosarcoma cells and play a role in gefitinib resistance in NSCLC through the miR-143/FOSL2 axis [PMC6463206, PMC6965519]. Furthermore, UCA1 has been implicated in epithelial-mesenchymal transition (EMT) formation and its expression patterns have been evaluated in renal cancer [PMC6584350, PMC6988374]. The mechanism by which UCA1 is upregulated and its role in osteosarcoma progression remain unknown [PMC5802028]. Additionally, UCA1 has been reported to be involved in endometrial cancer cell migration and proliferation, as well as endometriosis development [PMC8845243, PMC5707093, PMC9333278]. It is also associated with bladder cancer progression through activation of AKT signaling pathway by BMP9 [PMC5979556, PMC6698587]. The clinical significance of UCA1 expression levels have also been explored across various cancers including bladder cancer and ovarian endometriosis [PMC9570462, PMC6698587].

Genome locations

Gene Ontology annotations

Sequence

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UGACAUUCUUCUGGACAAUGAGUCCCAUCAUCUCUCCACCAUGCACCUUGUGACUCCCUCCUCUGCUGACAACAGAUAACCACCUUUAACUGUAACUUUCCACAGCCUACCCCAGCCCUAUAAAGCUGCCCCUCUCCUAUCUCCCUUCGCUGACUCUCUUUUCAGACUCAGCCCACUUGCACCCAAGUGAAUUAACAGCCUUGUUGCUCACACAAAGCCUGUUUAGGUGGUCUUCUAUACGGACAUGCUUGACACUUGGUGCCAAAAUCUGGGCCAGGGGGACUCCUUCGUGAGACCGGCCCCCUGUCCUGGCCCUCAUUCCGUGAAGAGAUCCACCUGCGACCUCGGGUCCUCAGACCAGCCCAAGGAACAUCUCACCAAUUUCAAAUCGGAUCUCCUCGGCUUAGUGGCUGAAGACUGAUGCUGCCCGAUCGCCUCAGAAGCCCCUUGGACCAUCACAGAUGCCGAGCUUCGGGUAACUCUUACGGUGGAGGAUUCCCAGCCAUAUGAAGACACCCUAGCUGGACGAUCAGUCCUUGUCAAAAGUCUGACCCCUCAAACUCUACAGCCUCAAUGGACCAGACCCUACCCGGUCAUUUAUAGCACACCAACUGCCGUCCAUCUGCAGGACCCUCUCCAUUGGGUUCACCAUUCCAGAAUAAAGCCAUGCCCAUCAGACAGCCAGCUUGAUCUCUCCUCUUCCUCCUGGAAGCCACAAGAUUAGGCCGAGAGCCGAUCAGACAAACAACCUACAACCCUUAAGCUCCUGGCAGCGCCCAGCCAAGGCCAUGCUUCCAUGCAACACUCCUUCCAAAUGGCCAUCCCAGCAUGCUUCCAAGCAGGCUUCAUCCGUUCCUCUGGACCCUCAUCUCUUAAGACCUGCCGCCUAUAAAAAGGAUUAUAUCUUGAGACCCUAUCCUCUAAAAUUUUUUCCACACCCAAAACAAAAAAUCUCUGGGUCAAAAGUCUAAAACGCUUAGGCUGGCAACCAUCAGAUCCUUGCCCAUGGUGUCCUCAAGCCUACUCUCAUGAAAUGGACAACAGUACACGCAUAUGGGGCCAGUUCCACAUAUUUGGCAACCAGACCAGCAUCCAGGACAACACAAAGUAUGUUGUUUGUUGUUAGAGGGCUUGGGACAUUUCACUCUUUGCCAGCCUCAGCUUAAUCCAGGAGACAAAGAUUAUUUUCCUUAUUAUCUCUUCUGCAUAGGAUCUGCAAUCAGAACUAUUGAACUUCUCCAUUCAGACCGCCACUCACACCUAUGGGAAAAGGGUAAUGUAUCAUCGGCUUAGCAACAGGGAAUACUAUUCGUAUGAUGGAAAAUGGGGACAAAAGGCUUUGGUACAUAAAACAUUAUUCCUUCCUUGGCCUAAAAACUCAUCGCCACCUACAUUAAAGCUAAUAUGCCUGAUUACUGUUUUUAGAGAACUUAUUUUAUUAGGGCAGUUCCAAGCUCAAAAAUACGCUAACUGGCACCUUGUUAGCUACAUAAAAAUGCACCCUAGACCCGAAACUUACUAGACUCAUUAUAAAAUUUUCUUUAAGGUGUCCACGCAGUCCCUGGUCACACUUGAAGCAGUCCGGAGAAAUAUCAGCCCUACCCCAGUAAUCCCCAGAAGGAACUUACACUUUUUUUUAAUCUUUUCCUACAACUUCAUAUUUUAUAAAUAAAAAGACAAAAAUGUCAGGCCUGUGAGCUGAAGCUUAGCCAUUGUAACCCCUGUGACCUGCACAUAUCCGUCCAGGUGGCCUGCAGGAGCCAAGAAGUCUGGAGCAGCCGAAAAACCACAAAGAAGUGAAACAGCCAGUUCCUGCCUUAACUAAUUAACCCACCUUACGACAUUCCACCAUUAUGACUUGUCCACCAUUAUGACUUGUUCCUGCCCUGCCCCAACUGAUCAAUCAACCCUGUGACAUUCUUCUCCUGGACAAUGAGUCCCAUCAUCUCUCCACCAUGCACCUUGUGACCCCCUCCUCUGCUGAGGAUAACCACCUUUAACUGUAACUUUCCACGCCUACCCAAGCCCUAUAAAGCUGCCCCUCUCCUAUCUCCCUUCACUGACUCUCUUUUCGGACUCAGCCCACUUGCACCCAAGUGAAUUAACAGCCUUGUUGCUCACACAAAGCCUGAUUGGGUGUCUUCUAUACGGACACGCGUGACAGGAACCUCAACCCAAAGGCAGUCUGAUGAGGUGUCUAAGAUAAAAGUAGCGGCACAAAGGCUUUUGUAAACAGAGGCGUUUCAUGUGGUUUUCCUUUCCUUUCCUUAUAUGUGAAAAGGUGACAGAAAAGAAAUCUUCCUAAAAGAGUCAG

Taxonomic tree

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Publications