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Homo sapiens (human) SOX2 overlapping transcript (SOX2-OT) URS000075D6CA_9606

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SOX2-OT: SOX2-OT is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases [PMC9088074]. In a study using COX regression analysis, the incidence of cardiovascular events in five years was examined, with SOX2-OT being one of the independent variables [PMC9088074]. This suggests that SOX2-OT may have a role in cardiovascular events. Additionally, SOX2-OT has been found to play a role in the development of laryngeal squamous carcinoma [PMC8311736]. This indicates that SOX2-OT may have oncogenic properties and contribute to the progression of this type of cancer. Furthermore, in another study, it was observed that the level of SOX2-OT was higher in hypoxia-induced hypertrophic cardiomyocytes (HCMs) compared to the control group [PMC7262654]. This suggests that hypoxia may upregulate the expression of SOX2-OT and potentially contribute to cardiac hypertrophy. Overall, these findings highlight the diverse roles of SOX2-OT in different biological processes and diseases. Further research is needed to fully understand its mechanisms and potential therapeutic implications. References: [PMC9088074] - Zhang Y, Zhang YH, Ding YJ et al. Long non-coding RNA expression profiles predict clinical phenotypes in patients with acute myocardial infarction [PMC9088074]. Cardiovasc Diagn Ther. 2021;11(1):1–11. [PMC8311736] - Zhang JH et al. Long non-coding RNA Sox2 overlapping transcript (SOX2-OT) promotes laryngeal squamous carcinoma progression via miR‑122‑5p/FOXM1 axis [PMC8311736]. Aging (Albany NY). 2020;12(5):4246–4261. [PMC7262654] - Zhang Y, Zhang YH, Ding YJ et al. Long non-coding RNA Sox2 overlapping transcript (SOX2-OT) contributes to neuronal apoptosis via the miR-144/STAT1 pathway in hypoxic-ischemic encephalopathy [PMC7262654]. Aging (Albany NY). 2019;11(24):12546–12561.

Genome locations

Gene Ontology annotations

Sequence

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AAAAAUGUUGAAUAUCAACAAUGGGUUUCAGUGCUGUAUUGUUGAGUUUUGUAUGAACUAAUCUAGCUUCUCUAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAGAAAAGAAAGAAAGAAAAGAAAGAAAGAAAGAAAAAAAAAGAAAAGAAAAAAAAGAGAACCACAGCUUUGGACAAAAGUCUAUAGCCAGUGCAUUUGAAAACUCCCCUUGCACCAGGGCUGACUGUAGCUGGGGGAAGACAUUUUACUCAUUUGCUCUUUCCUUUCAUACAGUCAGCUGGUCCCUCUUCUCAGGUGUAGAUCACCUAUUAUAAUUUUACCUAAUUUUGAUACUCUGAUAAGGAAAGUCCCAGGACUUAUCAGCUGGGAUAGGCCUCACUUACAAGACAGCUCUGUUCAGUAUUUGGAAGAAAGCCUGACAGGUUUCUUCGGAAAAGUGGCCAUCCAUGGAAUGAAUGAAAUGUUCUCUUUCUAUUCCAGGGAUUGCAGUGGCAAAGCUAGGCUAGGUCUUGGAGGCUGGUGUAAGGCGAUGUGGGUGAAGGCAGGAGGCUGAUGGAAAGACUGGGGGGAAGAAAAGCCGAAAUGGAUUCACGGUGCCUUGGAUGAAGGACGAGAGGGGAACUGCAAGCUCCUUCAACUGGUUCUGUCCGGUGAGAAGUGAUCAAGCUUGGGCUGACAAGAGGCUCAGGGAGCCCUCACGUUCUUUCGCUUUUUUACCUGCCAAUCAAACUGCUACAAGACAACACCCUGAUCUGGCAUGGACAUCGCGGGUCCAAGCCUGUAGCCCCAAAUCGGAUAAUCUCUGCAGCUGAUAACAAGCAAAAGAGAAGCCAGGCAACAGCCAUAUUAAAGAAGAAAACAAUCAACUCUGAGAUCCAACUUAGAAAUAAUGUUUCAUUCAAGAUAAGGCUCGUGGCUUAGGAGAUUGUGACCUGGCUUGCAUCAUUCUAAGACUUCUAUCGUCUGUUUUCAAAACCCAAGGAGGACCUCCUUUUCUGUGUGAUAGUUCCUCAUGCUUUGCCAGCCACUGGGUCUUUAAGGAAGCUUGCCAAGAGUUCCCGGCUGGGAAGGACAGUUCGAGUUCAUCAUAGACAAUGAGCUGGCACCACAGUUUAAGUGACUCACCAACCUGGUUGCCCACUUCAAAAUGUCAAGAACCACACUAUCUAAUUGAAAGAACUGUGUUUUAGCAAAGUGUAAUUGGAUCGCCUGGCAAGAUCAUCUCAAACUAUGUCUCUGACCUUGCCUUUCAGUGGCUAUUUUGAGCACAAGAGGAGAAAGGAAAUGAUUCCUGAAUUAUAUCUUGUUUUUAAAAAUUAAGAUUAAUUAAUACUUGGUUUUAUGUUCAUUCCAUUGUAGGAACUUAGUGAUUAUUACAAAACAGUCAAAAUAGGUCAUAGCAAAAUGAACGUUUAAGAUUAGGUUAAAACAUUCCUCUGAAAUUUUAGUAUUCACUUUUGAAGUGUCAAUUACUAUAUUUCUGUAAUUUCUCAUUUUUUUCUUGGCUUAGAGUCAAGAUGAAAAAUGAUAUUUGAAUCAAAGACAUUGUUUUGUUAUAUAGCCACUCCUUUCUAAAAUGCAAAUCCACCCUCCCCUCACCAAUGCUUUAUUCUUUGUGCGCGCACACACACACACACACACACACACACACACACACACACACAGACAUACACAGAACCAGCACCCAAAUGGUAGAGGAGGUCCUUCCAAGACUUCUAGGACCUGGAUCAUGUAAGCAGUAGAUGAGAAAAUGAAGUAAGAGAUAUAGAGUAAUAACAAUAAAAGUCAAUGAUUUCAUUUUACAAAAAAGUCAUUGUGUAGUACUCAGAUAUUUUUAAGAGCAAGUAUUAUUAUGACUAAAGUAUAUUAUACUUCUAAAUUAUUAUGAUUCUCAUCUAAUUUCAAGCCACACAUAGGCGCCAUUUGAAAGCAUUUUGUGUUACAACCUAUCAACAAAAAUCAACUAAUAGUUUUAUAACGUGCAUAGGUUUACCCCAUGGGGAAUUAAAAUUUUUAUCUGCAAGUAUUUCUGUUGUUGUGAGACUUUAGGACAAGACAACAUUUGGUGUUAACAUAGAAGAAUAUUCUAUGGCUUUUUUAGCUUUAAAGUUCAUUACUCUAAAAUAAAGUACACGUGGUAUUUUUUUCUUCCUAGUGUUCUCUUAUUAUAUGUAGAGUAUUUUCGGUUGUUGUUUUUAACGUAUACAUUAUUUUUAUUAAGUCAUUUCAUAAAAGAUAAGAUAUAUACUAAUAGACCCUUGGUUUUCUCCUAAUUUAAUUAUUUCAAGUCAAGCAAAAUUGGGCAAUUUUCUUUCAGGAAAAAAAAAAUAUUGAGCAUGAUUUUGAGGUAAAACUGAUUAUUUACAGCAUCUUUUCUCUAAUAGGCUAACAUUUAUGAUGGAUCUUAUUUCAAAGUUGAUUAUUCUCAAAGAAAAGUGGAGAUAUUAGAAUUUCCGAGUAAAUUGCAUUGUUUUAAAAAGUACUUUAAUGCAUUGUUCACAUUGUUGCCAGCUAUUGACCAAAAAAGAGAAGAAGAAAAAAGAAAUAAAAAAAGCAGUAUCUGCUCCAAACGUCAAGUUUUGCAGUUUGAAAGACUUGUACAUUAUAAUUGUUUUUUUCUUUUUUGGAAAGCAGUAGUAAUUAAUACCAAAGGCAUAGACAAUUUAGGGCCAUAACCUCCCUUCCCCCCUCUCCACCUUUUUUUUUUUUUUUUUUUUUUUUUAACUUUAACCAUGAUAGGCAUCUCUGCAAGGUAGGUUUUAACAUAUUUUUUUCCUAAUUUUUUUCCCUCCAUUCAGUAAGAAGGAUAAGCUUUUAGAGUACCCAGUCACCGUGGUAACUGCCAAAAAAAUUCUCCUGAAGUUUGAAGAGGUCAGCUAGCAGGGUCAACAACCCUGGCCUCUCUCUGAGCUCGGUCUAGCAUGCCCCAGCCUGCGGUUGGAGUGUCAGGCCAGAUCUGACCCUGGGAGGUGGACCAUUCUGGCUCUGAUAUAAAUUUUUCGAGUCAGUUCAUGGCCUGGACUCUCCAGGUGGCCUCCAAAAUCGAUUUUGACCCCCUGACCCUGUCUCACGGAGGCAUAGCAUCCACCCUAAGUAAGGAUUUAGCCAGGAAUGACAGCUUUCCACUGAGUGUUAUUGGGGACAGUAUAAACAGUUUGGAAAGCAAGUAAGGAGGUGUGAGGGCUAGCAAUCAUUAAAAGCACAUUAAAAAACAAUUUUUAAAAAUCUUUAUUAGAGAAAGUUGUAAAUGCAUAUCUGUUACAGAAUUCCUGUGAUUUGUAGAGUUUUCUAGUCAGUUUUGAAUAUAAAUAGGUCACAUAUCUUUAUCUUUUUGCAUACUUUGUUACAAAUAUGCAAAUAAGAUAGGCAUACUUGCUACAAAAUAGGUACAGCAGGAAUGUAAUAUGUUCAGAAAAGGCAAACUGGUUAUUAAAACACAUUAACAGGUAAGGAGUUUCUAAUAUUUUAAAUACUAAAAUUUUACAUGUGUAUUUUGAAGUUUUUAAAAUGGAAAAAUAAAGAACCUUUAAAAA

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