hsa-mir-591: Hsa-mir-591 is a microRNA that has been implicated in various cardiovascular diseases, including atrial fibrillation, coronary artery disease, and idiopathic dilated cardiomyopathy [13,42,43]. It has also been found to be associated with heart disease and ischemia [44,45]. In the context of acute myocardial infarction (AMI), the expression of hsa-mir-591 is regulated along with other inflammatory and oxidative factors such as TLR2, NFKBIA, and ADM [PMC8863347]. Nilotinib treatment has been shown to affect the expression of hsa-mir-591 as well as other genes involved in the ubiquitination/deubiquitination cycle and autophagy-ubiquitination pathway [1,31]. In a study on glioblastoma multiforme (GBM), hsa-mir-591 was found to be significantly deregulated and showed a new association with GBM [PMC8151942]. Additionally, hsa-mir-591 was among the top 10 down-regulated DEmiRNAs in a different study [PMC9814319]. Overall, hsa-mir-591 appears to play a role in various diseases and biological processes through its regulation of gene expression.