v24

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Homo sapiens (human) CIRBP antisense RNA 1 (CIRBP-AS1) URS000075D59F_9606

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CIRBP-AS1: CIRBP-AS1 is a long noncoding RNA (lncRNA) that has been studied in relation to breast cancer and lower-grade gliomas. In triple-negative breast cancer patients, low expression of CIRBP-AS1 is associated with a better prognosis [PMC8927645]. Conversely, elevated expression of CIRBP-AS1 is linked to poor prognosis in breast cancer and lower-grade gliomas [PMC9592759]. In breast cancer, CIRBP-AS1 is identified as a risk factor [PMC8927645]. Additionally, CIRBP-AS1 is upregulated in the LumA subtype of breast cancer and co-expressed with the PWWP domain-containing protein MUM1 [PMC9592759]. In lower-grade gliomas, CIRBP-AS1, along with other m5C-related lncRNAs (LINC00265, GDNF-AS1, and ZBTB20-AS4), has prognostic significance [PMC8927645]. Furthermore, increased expression of GDNF-AS1 and ZBTB20-AS4 in lower-grade gliomas is associated with improved survival, while elevated expression of LINC00265 and CIRBP-AS1 correlates with poor overall survival [PMC8927645]. The differential expression of ZBTB20-AS4, CIRBP-AS1, GDNF-AS1, and LINC00265 across various tumor types suggests their conservation in tumor progression [PMC8927645]. Additionally, a 10-m6A-related lncRNA signature that includes CIRBP-AS1 has been identified as predictive of prognostic risk in triple-negative breast cancer patients [PMC9843365]. Overall, these findings highlight the significance of CIRBP-AF as an lncRNA involved in the prognosis and progression of various cancers.

Genome locations

Gene Ontology annotations

Sequence

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AAAAUGCCUCCUGAGACUGGGGGGGGGGCUGGCUGUCAGGGAGGCCGCCCCGUCCUGGGGGGCACCUCAGGGCAGGUACUGACUUCCAUAGCCAGGACCUAGGCCGGGAAUCGGGAAGGGAUGGCCCCGGAAGUGAUAAGGCAGGAUUUCCAGGCAGGGGAAGUGGCAUUUAGGAGAACUGGCUAUUUAAGGGGGCGGUCAGUGCUGACACAGACAAAGCAUUCACUGGCUGGGAAUGGCCGCCACCCAGUGGCUCUGAGAACUAGACUUGGAAGUCUGGCACUGGGAGCUGUGCCAACUUGGACCAAACUUUGGGCGCAAAGCACGACGUGGCAGACGAGGAACCACACUAGAACGGGCCACGCCUACCCAAGAUUUACGAGGCCGUCCUUUCCCUCAUGCAAUCGCAAUGGGAAAAGGAGGAAACUAAGGCUCGGCCUCCCCUACUGAGCCUGGUUGGCGGAGGGGAGUCUUAAAGCCGCCGCCAUCUGGAGAACCAGCUUUACAAGGACCCUCACUCACUACUCUUCGGCGGCCCCAAAGCCUCUGGGGGGCCCUCUAUGGCCACCACUUGCUCCUCGCCCAGGAGUCAUCUCAUGCCGCCGCCUCCCCCAGCCCUGGUGGAAGAAGCCAGCGCGGACCCCUGCCUCUCUGCCCCAGAAAGUCUUCGGAGGGAUGACCCUCUGCUGACAAGCUGGGGGAAGUUGGCGUACAGAGACCCCCGCUUUGCUGCUCAUCCCAGGGAAAUCCCGGCCCCACUCCUGACCUCAGACUCACUUCCACCCUCAAGUGGAUCGAGGUGGGGGUAGCCAGGGGCGCUGUCUCCAGUGACAAGGUCUCUGGGACCCCUCAUGGGCUCAAGACCCCCUCCCCCAGGCAGCAGCUGUGUGAUUCAUCACCACCCCCUCUGCACCUCGGGCCCCCCCACUACAGCCGCCCCACUCCCCGUCAGCGGCAGCCGGCUGCUGCGUCAGCCACUCACGCAGGGUGGUUAUUAAAGGAGAGAGACAUCAGCACCGAGCUCCCCUGCGCCCGCCGUCCAUGCGGGAGGGGCCACCCACCCACUGGAGCCCCAGACGCGGGCGCCACAUGCCCAGCCUGGGAGCAAUUCAGGCCCAUUCUUUCUGAUCUGCGCCCCCAGCCCCCAGCCCCAGCAGUCAGCGCGGUGGACGUUCUCUGACCCAGAGCAGCCCUUGUAGGGGGGGAGUUGGAGGGGGUGCCUGGUAGUCACAGCGGCCCCUGCAUAAUUGCGUAAUUCUUGCCGCUCCCCCCAGCCCAUCGUUCCCUGGUUCUGUGAGCCUCUGCCUUUUCCUGGUUUUGCGAAGCGCCGUGUUCAUUCAUUCAUUCAUUCAUUCAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications