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Homo sapiens (human) GIHCG inhibitor of miR-200b/200a/429 expression URS000075D52A_9606

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GIHCG: GIHCG, a long non-coding RNA, has been implicated in various biological processes and diseases. In a study, downregulation of SPINTA-AS1 through siRNA treatment was found to promote Lapatinib resistance, while downregulation of GIHCG was associated with increased Lapatinib sensitivity [PMC6391897]. Additionally, si-GIHCG treatment was found to significantly increase the expression of miR-29b-3p in Ec-9706 and TE-10 cells compared to the control group [PMC7781470]. High expression of GIHCG was positively correlated with poor clinicopathologic factors and poor survival in hepatocellular carcinoma patients [PMC7670177]. Furthermore, serum GIHCG levels were found to effectively discriminate cervical cancer patients from healthy controls, suggesting its potential as a non-invasive diagnostic biomarker for cervical cancer [PMC6360414]. In another study using HeLa cells, the expression of miR-200b was measured in GIHCG stably overexpressed and control cells using qRT-PCR [PMC6360414]. These findings highlight the potential role of GIHCG in drug resistance, survival outcomes in hepatocellular carcinoma patients, and as a diagnostic biomarker for cervical cancer.

Genome locations

Gene Ontology annotations

Sequence

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GGAGGAGUUACGCAGGCAGGGUUGUGGUUGCUGGCUGUUACCAGGACAACCGGAGGCGAUUGACCGUUAUCUGCGGUUUGGAGCCGUUAGCGGGAGAGGCAGAGAUAUUCAGAGGUCUUUUAGGAUGCGCUAAAGGGUCGUGAGGGCUCUCUUAAAAUUUUCUUCACAAGCGGUUAUCCAGUCGUGCCCCGCGGCCCUGCUGCUGGCCCCGGGGAUCUGAGUCGUACCCUCUUGUUUUUCUCUGAGUCAGUCUUAAGGUGAAAUGAAGUGUGGCCCAGUGGCUCCUCACUGUCGCUUCUCUAGUUUUCUGCCUCCUUUUAGAAAAUUGAAUUGAAAAGACAGGAUGAAGUGGACACAGCAUGUGAAGACAAUUCUUUCAAGAAGUUUGGCUGUCAAGGAAAACAGAGAAUGUGCUAAAGAACAUACAGACACAGAGCAGACAGGCCACCUUUGCAACCACAUGGAGGUUUGUCUGAUAUUGAAGCUAAAGAAGCUAAGCUGGAAGACAGAGAGACCAAGUCCUGAUGACAUUGUUUGAACCCAGAGAUCCAGACAUGCCUGAAAACUAGUUUUACCACUGGACUUAUCCGUUGAAUGAGCCAAUAAACUCUCUUUUAUACUUAACCUUGGGUUUUACCUGGAUUUUUGUCAUUGACAGCUCAAAAUAUUCUAAUAUAGAAGUAUACAUCAUUAAAUCAAAAAAAAAAAAAA

Taxonomic tree

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Publications