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MIR30C1: MIR30C1 is a gene that interacts with several protein-coding genes, miRNAs, lncRNAs, and rRNAs [PMC9730017]. Two SNPs (GOLGA7 rs11337, MIR30C1 rs16827546) were excluded due to low minor allele frequency (MAF) [PMC5313634]. Frequent amplifications were observed in MIR30C1 and MIR30C2 genes, which encode the same mature miRNA, hsa-mir-30c [PMC4129468]. MIR30C1 on 1p34.2 had a high rate of loss in samples with a miR-30c cluster deletion [PMC5400605]. The same deletion was observed in MIR30C2 on 6q13 [PMC5400605]. The clones used for the study were RP11-2B6 for MIRLET7A1 (9q22.32), RP11-453C14 for MIRLET7A2 (11q24.1), CTD-2504J8 for MIRLET7A3 (22q13.31), RP11-170L4 for MIR30C1 (1p34.2), and RP11-756H9 for MIR30C2 (6q13) [PMC5400605]. These findings were obtained from a previous study that used array Comparative Genomic Hybridization to investigate the expression of let-7a and miR-30c genes in specific genomic locations [PMC5356719].
References:
[PMC9730017]
[PMC5313634]
[PMC4129468]
[PMC5400605]
[PMC5356719]
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