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Homo sapiens (human) TP53 target 1 (TP53TG1) URS000075D314_9606

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TP53TG1: TP53TG1 is a long non-coding RNA (lncRNA) that has been implicated in various cellular processes and diseases, including cancer. It has been shown that downregulation of TP53TG1 suppresses proliferation and migration of U87 cells after glucose deprivation, while overexpression of TP53TG1 has the opposite effect [PMC9606714]. TP53TG1 interacts with the DNA/RNA-binding protein YBX1, preventing its nuclear localization and subsequent activation of oncogenes [PMC5442347]. In hepatocellular carcinoma (HCC) cells, TP53TG1 knockdown enhances the efficacy of sorafenib therapy, suggesting that TP53TG1 is a potential target for improving treatment outcomes [PMC9414591]. In lung cancer cells (A549), TP53TG1 knockdown leads to a decrease in cisplatin sensitivity and apoptosis [PMC5863826]. In pancreatic ductal adenocarcinoma (PDAC), loss-of-function and gain-of-function studies have revealed the role of TP53TG1 in regulating cell function [PMC6726832]. Additionally, TP53TG1 has been shown to be involved in pulmonary fibrosis and its overexpression promotes cell proliferation and ERK activation [PMC8482154] [PMC9166247]. Furthermore, the expression level of TP53TG1 is associated with various markers in tumor tissues, suggesting its potential as a prognostic marker or therapeutic target for cancer treatment [PMC9746054]. The reason for the decreased expression of TP53TG1 in cancer is not yet fully understood [PMC9746054].

Genome locations

Gene Ontology annotations

Sequence

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CCCUGUCUCCAGUGGGCGUCUUGGGCCCCGGCUCUAUUCUGGGCUGCGGGCCUGGGAAGGGCUCGCCGGGUGCCAAAUGAGCUGUCCUAACUCUGCGGGGCUGCAGCUUCCUGCAUGAUGCUGGGGAGCUUGGCGCCUGACCCAGGAUCUAGAAGGCACUCUGGGCAGGCCGCGCUCCGCCCACGAAGGUACCCAACCCUCUGGGAUAGAUGCAGGAAGCGAUGGUUAAGACCCAUUUUCACCCAACUUCUCGCCGCAGGUCUGGCUUACCACACGCUCCUCCCCAUUCCCAGUGAGCCGCUUUUUGCAGCACCAGGCGAACACUUACACCAGUGCUUUGUAAAGGAAUCUUAUUGUCCACCCCGUGUCUUGGCAAAAGAACAGUGAUCACACAGAUUCCUACUUGGGCUCUUUCCUUUAAUCUUCGGAGGCUGAGUUUGCCCAACUCAGGUUUAACCACCAAGGACUCUGAGAGCUGGCAGGUCUGAGUAACCCUGGUAACAAUUCUCUUCACCUUAUCAAAACCUGAGCUAAAACCAAUGCAUCAGCUGAUGAUGACAGCAGAGAGUGGCAGGGCUGAGGACCCAAAGUCAUUUCCCAGGCUGGCGGAGAAUAAACUGCCAGGGAGAAGAAUGAGAAGACAGGAGACAAACUGUUUGGAAAGCUAAAUCUUCCCUCUUAAUGAAUAAAGGUUUUUGCCUUGUCUUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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Publications