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Homo sapiens (human) HLA-F antisense RNA 1 (HLA-F-AS1) URS000075D2CA_9606

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HLA-F-AS1: HLA-F-AS1 is a long non-coding RNA (lncRNA) that interacts with MEG3 and together they regulate various behaviors of GBM cells [PMC8678538]. The lncRNA MIR155HG and HLA-F-AS1 competitively bind with miR-650 and miR-375, leading to reverse-regulation of their expression and indirect targeting of annexin A2 (ANXA2) and profilin 1 (PFN1) [PMC8822266]. It is hypothesized that HLA-F-AS1 in the nucleus absorbs premature miR-613, thereby suppressing its maturation [PMC9275988]. Low expression levels of HLA-F-AS1 may indicate improved efficacy of anti-PD-1 treatment [PMC8161458]. Furthermore, HLA-F-AS1 mismatches between sequence variants are significantly associated with the risk of developing grade II–IV aGVHD [PMC9351719].

Genome locations

Gene Ontology annotations

Sequence

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AGGAAAUUUCUGGUGGGCCUUCGCGGCUCCGCUGGGUUGGCAGCCGCUUGAGCCACUGCGAGGAAAGCAAAGUCUGGGCCAUGGAGAUGAGCCUAGUCCUGCUGUUCCUGAUCCGCACUGCCCUUUUUGCACCCCAGGGAGCUGCUGCUGACGGCGCCUCCCUCUGUCGCCAAAGUUGGAGUGCAGUGGCGCGGUCUCGGCUCACUGCAAGCUCCGCCUCCCGGAUUCAAGUGAUUCCCCUGCCUUAGCCUCCUAAGUAGCUGGGAUUACAAGUGCCCACCACCACACCCGGCUAAUAUUUUGUAUUUUAAUAGAGACUGGGUUUCACCAUGUUGACCGGGAUGGUCUCAAUCUCCUGACCUCGUGAUCUGCCUGCCUAAGCCUCCCGAAGUGCUGGGAUUACAGGCGUGAGCCACCACACCUAGCUGGAAGAGGAGAUAAAUAUAUGAAGGUGCUGUUUGGCACAGAAUUUAAUAGGGAAGAAAGAGACAGUAUAACUCACCAGUGCUGGGUCUCAUCAUCCUGCAAUUUCAGAACAACUAUGAAUACAAAAAGAAUUUUAAAAUCCCAGUCCUGCCUAGAAAGGGGAAGUCAUCUCUAAAUAUGGUGGCCCUGGGGCAGCUGGCCUCCCUGCCAGGCCUCUUCCAUGGGGGCCCUUUCUGCAGUGACUGUGGUUUCUUCCCAUUUUACUCUGUCCUGUGUCCUGACUGAAGCGACAAGGUGUGUCUGCAGCUGUGCUCACACCUGGAGGAAACCUCAAUGGUCACAUCCUCUUUCCUGUGUCAAGAAGCAUCGUCCGGGGAGGUGAGAAGAAGACAGUCCUCCCUAGAAUUGAAGAACCAGGGAGAACCAGAUGGGCUGGGCAGGUGGGUUUUCACCUGGAACCUGGAGGAUGAGCAAUGACAUCUCUCCACCCUGAGCUCAGCCCCGGCAUCCACCUCCUGGGCUCAUGAGCAGUGCAGUGGUGCCUCCUAGUGGUCUCUGCUCUUCCUUUUCCAGAUCAAGCACAAACCUGAGAUCCAACUGUCCCUCUUAUGCGCCUGGGUUUCUUCACUGGACACCAGUAUGAGUCAACUUUCCUGUAAAGCAGAACAAGCACGAGAUUGGACCAUGUUAGAGGAGGAAUGGUGUCAUCUCCACUUCUGGAGAGAUCACUGUCCCCGUGUUUGGGGGAAGGACCAAGCCUCACUCCCAUGCAGAGAAGAAGCUCUGACUGUAACUGCACCUGUGGAGAGAGGAUUGCGGCCUGUUGGCAGAAGAGUAGUGUCUUGGGCCCCAGCUGACCUGAUGAAUAUCAACAUCCAAUGCCCUGUAAUGAAGUCAUGUGUGCACAUAUCAUCACUUCUGCAUGCAGUCUCAUGGGAAGAUGGUGCCAAGAACGAAGAAGGAAGCUCCUGCCCCUCCUAAAGCCGAAGCCAAAGCGAAGGCUUUGCAAGGCCAAGAAGGCAGUGUUGAAAGAUGUCCACAGCCACAAAAAAAACAAGAUCCACAUGUCACCCACCUUCCGGCGGCCCAAGACACUGUGACUCCGGAGGCAGCCCAAAUAUCCUUGGAAGAGCACCCCCAGGAGAAAUAAGCUUGACCACCAUGUUAUCAUCAAGUUUCCGCUGACCACUGAGUAGGCUGUGAAGAAGAUAGAAAACAACAGCCUACUUGUGUUCACUGUGGAUGUUAAAGCCAACAAGCACCAGAUCAAACAGGCUGUGAAGAAGUUUGUGACAUUGAUGUGGCCAAAGUCAACACUCUGAUUCAGUCUGAUGGAGAGAGGAAGGCAUAUGUUCGACUGGCUCCUGACUACGAUGCUUUGGUUGUUGCCACCAAAAUUGGGAUCACCUAAACUGAGUCAAGCUGGCUAGUUCCAAAUAUAUGUAUAUCUUUUCACCAUUAAAAGAAUCUUAAUCUCUCAAAAAAAAA

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Publications