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Homo sapiens (human) long intergenic non-protein coding RNA 254 (LINC00254) URS000075D281_9606

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LINC00254: LINC00254 is a testis-specific non-coding RNA (ncRNA) that inhibits the expression of CTG MEIOB through the expression of nearby testis-specific ncRNAs [PMC9196322]. Although LINC00254 is not expressed in any of the LUAD cell lines tested [PMC4737856], it is located 6 kb upstream of MEIOB [PMC4737856]. Guide RNAs were designed to recognize the specific regions of MEIOB and LINC00254 and cloned into PGL3 [PMC4737856]. In addition to coding genes, LINC00254 is identified as a testis-specific ncRNA near MEIOB, and it can act as a natural inhibitor of MEIOB [PMC4737856]. In the A549 cell line, overexpression of LINC00254 downregulated MEIOB, leading to similar results as observed in the MEIOB knockout [PMC4737856]. This suggests that LINC00254 may play a role in inhibiting the expression of MEIOB [PMC4737856]. Overall, LINC00254 is a testis-specific ncRNA that can inhibit CTG MEIOB expression through its interaction with nearby testis-specific ncRNAs. It is not expressed in LUAD cell lines but is located upstream of MEIOB. Overexpression of LINC00254 downregulates MEIOB expression, indicating its role as an inhibitor. These findings highlight the potential regulatory role played by LINC00254 in controlling gene expression in the context of testicular function and development.

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Gene Ontology annotations

Sequence

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AGAAAAAGAGACUGCAUACAACGUUUCAUUCAUGUUUUGCUAGGCUAGAUACAUUUGUUGUAGCGGUCUCAUAUUUGUAAGUCCGUGGAAAAACCUGAAAGUAUUUUUUUCUUGAAAAUUUUUUUGAAAAAAAAGUAAAAUGUCAUUAGGAGUGAGAAUCAGGAAUGAUGGAUUCACGGUCUAGUUGCAAGACUCAUCACAGGCCAUUAACCUCUGAAAAGCCUUUAUCUGCUUCGCUUUGUUACAUAUCAGACGCGGAUAUUACUUACGAGUAUUGAAUGAUCCCCUCAGUAAACACCAGCUAUGCAGGAGGUGCUACCUUAGCAAUAGGAGCUUCAGUCUGGGAGGAGAGUGGGACAUAUAAGCAAAUAAAUACAUCACGUUUCCCACAGGGCGCGUAUUUUGUGUUCAUCUUCGUCCCACUGGAUCUGUCCAAACUUUUCAUUUUUGACAGAUAAGGAAAAUGAAGUUCAGAUGCUUGAGUGACACAGCUAAUUAGUGGCAAGGCUGAGACUUUUGACCAGACAGCCUGACUUUUAGUUUCUACCAUGCAUGUUAACUCCUCCUAAACCCCAUUUAUUUUCUCAUUUCAGACAACUGCGCAAUAACACUGCUAAGAUAAAAGCACUCUGAUUAAUAAACACUGAAAUUAAGCAGGUUAAAAAAAAAAAA

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