MIR6852: MIR6852 is a microRNA that plays a role in regulating cystathionine-β-synthase (CBS)-mediated ferroptosis inhibition in cancer cells [PMC7045519]. It has been found that LINC00336 acts as an endogenous sponge for MIR6852, regulating the expression of CBS and promoting ferroptosis [PMC9247141] [PMC7864727]. LINC00336 is also shown to increase CBS expression and inhibit ferroptosis in lung cancer by acting as a circulating extracellular DNA (ceRNA) sponge for MIR6852 [PMC9263225]. The relationship between LINC00336 and MIR6852 has been investigated, with evidence showing that MIR6852 suppresses colony formation while the MIR6852 sponge increases colony formation [PMC6889193]. The expression levels of MIR6852 do not affect the mRNA expression of LSH, indicating a specific interaction between MIR6852 and LINC00336 [PMC6889193]. Furthermore, the overexpression of MIR6852 increases erastin- or RSL3-induced growth inhibition, while the MIR6852 sponge decreases this inhibition [PMC6889193]. It has been demonstrated that CBS is directly targeted by MIR6852, leading to decreased CBS expression and increased cell death [PMC6889193] [PMC7277093]. Overall, these findings suggest that LINC00336 acts as an endogenous sponge for MIR6852 to regulate CBS expression and promote ferroptosis in lung cancer cells.