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Homo sapiens (human) non-coding RNA activated by DNA damage (NORAD) URS000075CEFB_9606

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NORAD: The expression of NORAD was tested during the progression of fracture healing [PMC9886463]. Downregulation of lncRNA NORAD significantly elevated miR-30a-5p expression in OGD/R-injured SH-SY5Y cells [PMC8810080]. Knockdown of lncRNA NORAD aggravated oxidative stress in OGD/R-injured SH-SY5Y cells [PMC8810080]. YWHAG overexpression could significantly ease oxidative stress aggravated by downregulation of lncRNA NORAD [PMC8810080]. LncRNA NORAD has impacts on oxidative stress and inflammation in SH-SY5Y cells injured by OGD/R [PMC8810080]. The viability of OGD/R-injured SH-SY5Y cells was partially reversed after transfection with miR-30a-5p mimic [PMC8810080]. YWHAG overexpression abolished the pro-apoptotic effects of lncRNA NORAD interference under OGD/R condition [PMC8810080]. Elevation of YWHAG could mitigate cell apoptosis and reverse the pro-apoptotic effects of lncRNA NORAD interference in OGD/R-injured SH-SY5Y cells [PMC8810080]. The inhibition of lncRNA NORAD overexpression in the apoptosis of OGD/R-injured SH-SY5Y cells was reversed by upregulation of miR-30a-5p [PMC8810080]. Upregulation of YWHAG enhanced the viability and repressed the apoptosis, abolishing the function of lncRNA NORAD knockdown in OGD/R injury [PMC8810080]. The suppressive effects on viability and promoting effects on oxidative stress and inflammation were reversed following YWHAG overexpression upon downregulation of lncRNA NORAD in OGD/R-injured SH-SY5Y cells [PMC8810080]. Downregulation reduced the viability, promoted apoptosis, and increased TUNEL positive cells, Bax, Cleaved caspase-3 expressions, and decreased Bcl-2 expression in OGD/R-injured SH-SY5Y cells [PMC8810080]. LncRNA NORAD overexpression enhanced the viability and suppressed the apoptosis of OGD/R-injured SH-SY5Y cells [PMC8810080]. NORAD might be a novel therapeutic target for the treatment of glioma [PMC7392058]. NORAD knockdown partly reversed CDDP resistance in KYSE30/CDDP-R cells [PMC8662861]. NORAD knockdown reduced the colony formation abilities of KYSE30/CDDP-R and TE1/CDDP-R cells only when they were treated with CDDP, not PBS, indicating that NORAD knockdown partly restored the sensitivity of these cells to CDDP [PMC8662861]. Knocking down NORAD expression significantly reduced the IC50 value of CDDP, indicating that this change rescued CDDP resistance in KYSE30/CDDP-R and TE1/CDDP-R cells [PMC8662861].

Genome locations

Gene Ontology annotations

Sequence

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AGUUCCGGUCCGGCAGAGAUCGCGGAGAGACGCAGAACGCAGCCCGCUCCUCCAGGGCCCUCCAGGCCCUCCGGCCCCGGGCCGGCGGGUGAACUGGGGGGCCCCGGGACAGGCCGAGCCCUCUGCCCUGCAGAUAACGGAGGCCUCUGCUGUGGCUGCCCACUGGCUGUGCCCGCCCACUGGCUGUGCCCAGACCUUGAAGCCGCAGCGAACCUCUCUUUCCCACCCCACCUCGGUGACUAAUGGCGGCCGUGGCGUCUCCCAGCCCGGACCCCGCCGGCACCCGGGUCUCCCGACCCAAGCCUCGACGAAACCCCCGCAGAGCCGCCGGGACGCAGCGCCUUUGGGCGGCGCUGGGCGUGGUGGGCCGGGAAGUAUGGCGGCAGCUCGAACGCCGCGCGGCGGAGGCCAUUAAGGCGUGGACGGCCCGGGAAGGCGGCCUAGGGACGCAAGCAGGCUCGGCCGCCUCUUUAGGCCACGGAGCCGCGCAGAUCCGGUUCCCGGGUGACCACUCUGUCGCCAUUGGGCGAGACCUACCUAGUCCUGACGACAACGGACAAAGGCCUUAAGGGGCCUGGAAGGUGAGCGAAGUCCCGAACGACGACGGGUGGAACGGUUAGCGGCCAUCGGGCGGUUGGUCUUCAUUCUACCAGACUUUGCUGUCGGAAGAGAGAAAUGGUAGAAUGACAGGCCACGUUUGGCCCGUUGGAAAUGCCCACCACCCUCUGGGAAGAUUUACUGGCCGUUUAUGGAAGGCCUGUGUAUAUAAUAUGAAAAAGCUGCUCUCAACUCCACCCCAACCUUUUAAUAGAAAACAUUUGUCACAUCUAGCCCUUCUAGAUGGAAAGAGGUUGCCGACGUAUGAUAAAAUAGAGUUAGAAAGUUACACAUCUUGUAAAUUCUCAUUUGUUUAAAAGAAAUCAUAGAAAAUACAUGUCUUCUGGAGAUGACUUUUGGAAAUGGAGUUGUUAAGACGGCCUCUGGAAGCGAUACGUCCACGUUUGUUAAGUGGGUUAGAUGACAUGGAGCUGGAAGACCUGAGAAGGAAGAGAAGAAGGUUCUAUGCUAGACUGGUCAUAUUUAGAAGACAUUUUCAUAUUCUAUCCAUUGUUUUGUGUGCAUUUUAUUCCUCACUACUGUGUAUAUAGUUGACAAUGCUAAGCUUUUUUGAAAUGUCUCUUCUUUUUAGAUGUUCUGAAGUGCCUGAUAUGUUAAAAUUAGAGGUAGCAAAAUCACAUUUUGUAAAUACCUUUUUGUUACAAUUCAUAGGAAAUAUUUUUGGGGGGGAAUGGCCAAAUCACCUGUUGAGUAAUACUCAUUGUGUUUGUGCAGUGGUUCAGGGGAGGAGAGAGGAGGGGGAGGUGCAGAGAGCUCUAUGCCAUCCUGUUUACAGCGAGGCAAGAUGAAUCAUUAUGUCUGUGCAUUUUGUUUUACUUAUCUGUGUAUAUAGUGUACAUAAAGGACAGACGAGUCCUAAUUGACAACAUCUAGUCUUUCUGGAUGUUAAAGAGGUUGCCAGUGUAUGACAAAAGUAGAGUUAGUAAACUAAUAUAUUUUGUACAUUUUGUUUUACAAGUCCUAGGAAAGAUUGUCUUCUGAAAAUUUGAUGUCUUCUGGGUUGAUGGAGAUGGGAAGGGUUCUAGGCCAGAAUGUUCACAUUUGGAAGACUCUUUCAAAUUAUAACUGUUGUUACAUGUUUGCAGUUUAUUCAAGACUGCUGUAUACAUAGUAGACAAAUUAACUCCUUACUUGAAACAUCUAGUCUAUCUAGAUGUUUAGAAGUGCCCGAUGUAUGUUAAAUGUAUAGGUAGUAAAAUACCACUUUGUAAAUAUCUUUUUGCUAAAAUUCAUAGGAAAUGCUUUUGGAAAUUGAAUUGUGAAGCCACCUUUGUGAACAGUAUAGUAAUGUCUAUACUUGUUCAAUAGUUUAGAGGAGGUAGGAGGGAAGAAAUUGCAAAAGGUAAUAUUACUAGUGUGUUCAUACUUGGACAUUUUCAGACACCAUUUUUCUAUAUGUUUUGUGCAUUUUGUUUUGCUCUGUAUAUAGUAUAUAUAAUGGACAAAUAGUCCUAAUUUUUCAACAUCUAGUCUCUAGAUGUUAAAGAGGUUGCCAGUGUAUGACAAAGGAGUAAAAUUAGCAUAUUUUGUACACUUUGUGUUGAAAUUCGUAGGAAAACUUGUCUUCUGUAAAGACUUUUGCAUAGGAAUUUGUUUGACCAUCUCUAAGCAUUACACGUGCCUGUACUUGUCCACUGGAUUGAAGGCAGAGAAGGAAGGGAGGAGGGAAUGAUUCAAGGCCAAAAUGGCCACAUUUAGAAGAUACCUCAGAUGAUAACCAUUGUUAUGUGUGUGCAAUUUUAUUUAACAGUGCUGUGUAUGUGGUGGACAAGUUAUAUGAAAUAUCUAGUCUUUCUAGAUAUUUGGAAGUGCUUGAUGUAUUUAAAAGUGGUAGUAGAAUAACACUUUGUAAAUAGCUUUUAAAAACUGAUGGGAAAUGCUGUUUGGAAGUGGAAUUGUUGAACCACCUGGGAGGUGGGAGGGAAGAAAUUGCAAAUGGUGUUUUGCCAUUGUUUAUUAGAAAAUUUCAGCUUAAUCCAUUGUGUAUAUGUUACAUGCAUUUCAUUUAACUUUGCUAUACUGUAUAUAUUGUAUAUAUAACGGACAAAUUAGUCCCGAUUUUAUAAUAUCUAGUCUCUAGAUAUUAAAGAGGUUGCCAAUGUAUGACAGAAGUAGAGUUAGUAAACUAACACAUUUUGUACACUUUGUUAAAAUUUGUAGAAAGGCUGUCUUCUGAAAAGGACUUUUGGAAGUGAGAUAACAUCAGCUCUAAGUGACACGUGCCUAUAUCCAUCAGGUUGGUGGUGGAGAGGAGUUGGAAGGAAUGAAGGGUUCUAGACCAGAAUGUUCGUAUUUAGAAGACACUAUCAGAUAUAACCAUUGUUACAUGUGUGUAGUUUAUUCAACCCUACUGUGUAUAUAGCGGACAAACUUAAGUCCUUAUUUGAAACAUCUAGUCUUUCUAGAUGUUUAGAAGUGCACAAAGUAUGUUAAAAGUAGAGGUAGUAAAUAACACAUUUUGUAGCUAUCCUUUUGAUAUGAAAUAUUGUCUUGGAAAUUGAUCAAUUCUCUGAGCAGUACCCAUUUUGAUAUUUGUGCUGGUUCAGGGGGAAGGAGGAGCACAAAGUGCAAAGGGCUUUCUACCAGUGUCCAGUGUGUUUAUGAGGAGGCACAUUGACCAUUGUCCCUUAUGUCUGCAUUUUCAUUUACUGUGCUGUGUAUAUAGUGUAUAUAAGCGGACAUAGGAGUCCUAAUUUACGUCUAGUCGAUGUUAAAAAGGUUGCCAGUAUAUGACAAAAGUAGAAUUAGUAAACUACUACAUUGAGUACACUUUGUGUUAAAAUUCAUAGGGAAGACUUCUUAAAAACAAGUGAAAUUGUUAAAACCCCCCCUAAGCAUUACAGAUGGCUUAUAGCUGUCCACGGGGUUGGUAGAGGUGGGAAAGGGAAGGGUUCUAGGCCAGAAUGUUCCUAUUUAGAAGACACUCAAAUUACAGUCUGUGUUAUGUAUGUAUACCAUUUAUUCAAUGCUACUGUGUAUAUAAUGGAAAACUUAAGUCCAGUUUGAAACAUCUAGUCUUUCUAGGUGUUUAAAAGUGUACAACGGCCUGUCGCAGUGGCGCAUGCCUGUAAUCCCAGCACUUUGGGAGGCCGAGGCAGGCGGAUCACGAGGUCAAGAGAUCAGGACCAUCUUGGCCAACAUGGUGAAACCCCAUCUUUACUAAAAAUACAAAAAUUAGCUGGUCGUGGUGGUGCCCACCUGUAGCCCCAGUUACUCGAGAGGCUGAGGCAGGAGAAUCGCUUGAACUUGGGAGGCGGAAGUUGCAGUGAGCCAAGAUCGCACCACUGCACUCCAGCCUGGCGACAGAGCGAGGCUCCGUUUCAAAAAAAAAAGUGCACAAUGUAGGUUAACAGUAGAGGGCUUAAGUAACACCCCUCUAAGCAUUUGUUUUCAGUACUUCCUAGGAGUGGUUGCAUUUGGGAAUGGAAUUGUUAAAACUUGAUGCUUAGGAGCGAAUGCAGACUAUUCAUUGGGUGUUUGGGGUGGGGGAAGGGGGGGUGGGCAGAGGAGGUAUGCAGGGAGAGGGGUUCUGUGCUCCUGAGAUUAGUUCAGAUGGUCUAACCAUUGUUCUAUAUGUGCAUUUUAGUUAAUAUUGUGUAUUAAAGGAUAAGUCUUAAUGCUCAAAGUAUGUUAAAAAUAGAUGUAGUAAAUCAGUCCCUUUGUGAAUGUCCUUUUGUUAGUUUUUAGGAAGGCCUGUCCUCUGGGAGUGACCUUUAUUAGUCCACCCCUUGGAGCUAGACAUCCUGUACUUAGUCACGGGGAUGGUGGAAGAGGGAGAAGAGGAAGGGUGAAGGGAAGGGCUCUUUGCUAGUAUCUCCAUAUCUAGACGAUGGUUUUAGAUGAUAACCACAGGUCUACAAGAGCGUUUUUAGUAAAGUGCCUGUGUUCAUUGUGGACAAAGUUAUUAUUUUGCAACAUCUAAGCUUUACGAAUGGGGUGACAACUUAUGAUAAAAACUAGAGCUAGUGAAUUAGCCUAUUUGUAAAUACCUUUGUUAUAAUUGAUAGGAUACAUCUUGGACAUGGAAUUGUUAAGCCACCUCUGAGCAGUGUAUGUCAGGACUUGUUCAUUAGGUUGGCAGCAGAGGGGCAGAAGGAAUUAUACAGGUAGAGAUGUAUGCAGAUGUGUCCAUAUAUGUCCAUAUUUACAUUUUGAUAGCCAUUGAUGUAUGCAUCUCUUGGCUGUACUAUAAGAACACAUUAAUUCAAUGGAAAUACACUUUGCUAAUAUUUUAAUGGUAUAGAUCUGCUAAUGAAUUCUCUUAAAAACAUACUGUAUUCUGUUGCUGUGUGUUUCAUUUUAAAUUGAGCAUUAAGGGAAUGCAGCAUUUAAAUCAGAACUCUGCCAAUGCUUUUAUCUAGAGGCGUGUUGCCAUUUUUGUCUUAUAUGAAAUUUCUGUCCCAAGAAAGGCAGGAUUACAUCUUUUUUUUUUUUUUUAGCAGUUUGAGUUGGUGUAGUGUAUUCUUGGUUAUCAGAAUACUCAUAUAGCUUUGGGAUUUUGAAUUGGUAAAUAUUCAUGAUGUGUGAAAAAUCAUGAUACAUACUGUACAGUCUCAGUCCCAUAAAAUUGGAUGUUGUGCCUACACACAGGAUCUAGAAGAAUAUGUCAAACUAUAAACUGCUUGUGAUUGUGAAUGACUUUGUUCUUUGCUUGUGUUUUUCAAUUUCCUAUAAUGCACAUACUAACUUUUAAAAAAUAAAGGUUAUUUUAAAAGCCUGUAUUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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