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Homo sapiens (human) HAS2 antisense RNA 1 (HAS2-AS1) URS000075CDC2_9606

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HAS2-AS1: HAS2-AS1 is a long non-coding RNA (lncRNA) that regulates the expression of HAS2, a gene involved in various cellular processes [PMC9367353]. It has been shown that HAS2 expression is regulated at both the transcriptional and translational levels, and can be influenced by factors such as PDGF-BB and phorbol 12-myristate 13-acetate (PMA) [PMC9367353]. In human osteosarcoma cells, HAS2-AS1 has been found to inhibit the expression of HAS2 [PMC6396505]. This inhibition is mediated by the sponging of miR-137 by HAS2-AS1 [PMC8173206]. The increased expression of HAS2-AS1 in HFL-1 cells under hypoxic conditions may be partly due to the activation of C/EBPβ [PMC7994614]. Additionally, bioinformatics analysis has revealed that the expression of USF1 is up-regulated in tumors and positively correlated with the expression of HAS2-AS1 [PMC7442972]. The levels of both HAS2 and its natural antisense transcript, HAS2-AS1, decrease significantly in certain conditions [PMC9367353]. Furthermore, it has been found that hCG can target and promote the expression of lncRNA HAS2-AS1, which in turn regulates cumulus expansion and migration by promoting the expression of HAS2 [PMC9208217].

Genome locations

Gene Ontology annotations

Sequence

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AAUUGCUCCUGAGACCCAACAGGCAGCAACGGUCCCAAGGGUGAGGGAGUGGGCAGGGAGAGGCUGAUGGGGCUUCUACACGUUCCCUCCCGUAGCUGGGCUGCUGCAGCUCGUUCGCCCCAGAGGCGCGCGGUGUCCUUGAGUCCAAGUAUUCAGCGCGGACGUUUGGGGGACGGAGGGAGAGGCGCUAGGGGAACUGGCACCUAAGACUGUGUAAUAGGACACAGGUCUUGCAAGUCCUCCUCCCCAGGCACCGCCCCUGUGCUCCCAGCGCCUCUUUGCAGCUUUAAUUAUCCUUUCAGCGCCGUUCCCCCGCGGCUGCGUUUCCGUGGUCAGAGGAAAAAGGCUCUUUCGCCUCCCGGUUCUCACCCUCAUACAGACCCUCCUUUCAGACCCGCCCUCCUGUUCACAGGGACCCAUUUCGGAGCCCUGGCUCACGCUGGGCGGGAACUGCCGUGACGAAUUCCCCCCAAGGUGUUGAUUAUCCAUCCCAACCCAGCCUCUGGCUUCCCUCCCACCUCCACCCCAGCUCCCACAGGCCCCUCGCCCCGUUCAUCGGCUGGGCGCUCGAGACGGCGCCCCCAGAUCUCCCACCGGGCAGUGUCCCCAGCUGCAGCUGAGGAGAGAAGCGCCGGCGUGCGCGGUGCCACGUCGGAAUUGGCUCUGGGGACGCCGCAGCUGCCGAAGCGCAGCGCGCGGUCCCCACGCACGCCCUGCCUCCGGGCGGCCGGCGGGCUGGCCCGGCGAGGAGAGGAGGGAUGCGCGCCCUCCUCCCGCUCCUAUCUGCGGGUGCCACCGCCUGCGUCAGGGACCCCUGGCCCGAUCUUUCUGCCCCCGAUAACAGAAAAUCUCUUUUUCGUCUUAAAAAAAAAAAAAAAAAAAAAAAAAGCCUGUGGAAGACUCAGCAGAACCCAGGAAGCGCAGAAUUGGGAGAAAAGUCUUUGGCUGGGGCUGUUUCAAGUCUCUGGUUCAAUGGGCUGCUCGAAGCCAGGACUGGGUAAUUCUUUCCAGACGUCUUGACUUCUCCUUCCCCGCCGUUGUUGCCCUUCUGCCUCCUCCAACUUAAGGGGGUCUUAACAAGAUCUUCUGAGGGGUGGACUUCUUUGGAACUCGACAGGACCUUGAAGACUGGGUUCUUAGUCCUUAUCACAUAUAUGGGCUAUAAUGAAUAAGUCUAAACAGAAAAGUCGAAUAAACUGGAAAUGAUGCUUUCAUCACGUCGCACAAGGAGCUGUUUGGAUCAGAAGAUGACAUCCUUUCACCCAUCCCUUUCAGGUUUUGACAUCCUAAAAUGUACCUUAUGGAACCCAUACCUGUUAUGUUUUCACCUGUACAAGGCAACAGAGAAAACAUGGUAGUUUUUACUUGAGUAGAUGUGACUUAGCAAUAUGUUGUUGCUGACCUCCAUCCCACAGCACAAAACAUAUGUUUAUAUGUCUGACAGACAAAGUAUCCAGAACAAGGAUUUAGUACCUUCAUAAUCCUCUGUAUAUGUGGUUCUAGAACUUUUGGUAAAGAAACUCUUUAUACUCUUAUUAAUUAUUGAGAACCUCAAAAAAAGUUUAUAUGUUAUAUGUAUCAAUAUUUACCACAUUAGACAUUAAAGCUGACUUAAAAAGUUAAAAUACUUAAGUCAUUUGAAGUAAUAAUAAAUGCAGUUACAUACCAACUUAAUAACAUUUUGCGAAAAUAGCUAUUUUUCAAAACCUAAAGUGAGAAAAGUGGCAGUUUUCCAUUUUUGCAAAUCUCUUUGCUGUCUAGCUGAUAGAAGACAGCUGGAUUCUCCUAUUUGCUUUUGCAUUCAAUUGUUGUUUUGAUUGAAGUAUAUGAAAAAAAAUCUGGUGUCAUACACAUAUAUAAUUGGGAAAUGGAAGAGUAUUUACACAGGCUUUUUUAGAUAUUCUUCCUUUAUACUACAUCAAAACUUGAUAAGUUGCAAUGUUGUGAAUUGGCCCAGGGCUUGGCCCUCUGAAGAUUUGCUGAAAAUCACUGACAUGAAGUAGAUUAAUAGGAUAAAAGGCAUAUACAUUUAUUUAAUGUGUAUACACAGCGGCCUUUAGAAUGAAGACCCAAAGAUACAGAAGAAAUUGUCUGUUUUUAUGCUUAAGUUUAACAAAGAAUGGGCAGCCGUGUAGAGAUAGGAUAGGACAAAAAGGGCAUAAUCUAAUGCUAGCUGACUGAGUGAGGAAGCCCAGCAAGGCCUGUCAGUGUCUCCUCAGUAUGAGUGAAUUUUGUGUACUCUGAUAAUACAUUAAAAUCUGUUUAUGUACUCUGAUAACACAUUCAAAAAAAAAAAAAAA

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