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Homo sapiens (human) LPP antisense RNA 2 (LPP-AS2) URS000075CD7C_9606

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LPP-AS2: LPP-AS2 is a long noncoding RNA (lncRNA) that has been studied in relation to its role in downregulating the activities of miR-7 [PMC8004586]. In breast cancer, it has been found that LPP-AS2, along with other lncRNAs such as LINC00115 and XIST, binds to miR-7 and downregulates its activities [PMC8004586]. The effects of LPP-AS2 on apoptosis were investigated through the use of TUNEL assays and flow cytometry following its silencing or overexpression [PMC7510091]. These experiments aimed to analyze the impact of altering LPP-AS2 expression on apoptosis [PMC7510091]. The results obtained from these assays provided insights into the role of LPP-AS2 in regulating apoptosis [PMC7510091]. Overall, these findings suggest that LPP-AS2 plays a significant role in modulating miR-7 activity and apoptosis, particularly in breast cancer cells [PMC8004586] [PMC7510091]. Further research is needed to fully understand the mechanisms by which LPP-AS2 exerts its effects and its potential as a therapeutic target for breast cancer treatment.

Genome locations

Gene Ontology annotations

Sequence

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CCUCGAGCGCGCCGCCCGCGCCCAGCGCCCCACGCCCCGCGCCCCGGGCCGUGCAGCCAGCCCUUACCUUGCAGCGCCCGGCUGUCUCCCGAUCGCUAAAGCUACUUAUCCCGGGAAAGCUCGCGCGGGACCCGGGAACGAACCCACAGACAAAAAGUGAAACUUCGGCAGGGCUGGAGCGGCUGCUGGUUGGUGCCUUUCCCCCUCCUUCCUCCCCACCGUCCCCACCCCCUCCCCUUGGUCUCCCGUGCGGUGCCCUGAGCGCUGGAGGCUGACGUCAGGGGCCUGAAUUCCUGACUUUGCCUGCACGCAUUUGUCCAUGUAAGGUAUGGGAAGGCGUGUGCCCGCGAAGCCGCCGCGCAGAGCUCGCCUGGCGGGGGAGGGGAAACCCGCAGCCGGCAGUGGCUUUGCCAAAAGGUGGGCGCACUGAGGGCAUUGCAUUUCCUGGGAGGAAGAGGAGGAGACGCGGGAAUGCAGGGAGCUUGCAAAGGAGGAAGAGAAAGAGGGAGAUGUGGAGACUUUGCCCCUGCUAGAGGAAGAGGAAGGAGACGUAGGAGGAAGCGGCCGCGUCAGGGGGCUCCUGGAAAAUGGAAAAGCCUGCGUCUACUAUUAAGGCGUCAAAUUAGGGCACUGAGCUUGAGUGGAAGAGAUCCAGCCAUGAAAUCCCCUUCCAAGAUUUUCCUCGUGAGCCCCGCCCUGGAUUCCCAGCAAGACUCAAAACUUACAAGGUGUCAGAGCUGGCAAAGACCAACUUCCAACCCGUCCGCUUGGCACGUGAGGAAACUGAAGCUCUCGGAAGAGAAAUGACUUGUACAGGGUCGUCACUCAGCAGAUCGAGGAGCGGGCCCAGGCGCUCUGCCUCCCACUUGGGUUCCCGCCUCCAGGAAGGGCCCUGGCUCCCUUUUAGCCCUGAGCCUUGAAGCAGGUUAGAUGCCCGCGAGCUGUGCGGACCACCCAGUGAUUUCUACUGCUCUUGGCCCAGAGCCAGUUCCUGGAAGGUCCUGGUUGACAGCGAGCCCUGAAUAUCAAUGACAAUCAGUUGCUUCAGGGCAACUUCCUCUGUCCUGUGCUCAAAUAAAUGAAUCCCUGGAGUUUAACGUUUACUUCUGAGCCCCGCCCAGAAAGCUUGCUCUGUGCUUAUAGCUUCAAAAAAGUCUGCGAACGAGAUGAACUGGUUUGAAUACAGACAAGCCUGUCAUUGGAAGUUUUGAGUUGGAUUUUUCUUUCCCCUCUGACAUCUGUAAGGGUGAACGACGAUGAGAACCACCACUUAACUGUGUUAGGGGAUUAUGACGCGCAGCAGCCAUGGCCAGGAAAGCAUUCCAUACCCUGAGACUUCCUUUCCUUGCACUUCUCUCCUAUUAAUAUCUAAAGUAAUCCCUCACGUUAGCACAUAAUGAAAGCAGUCUCUCACCCGGCUAUUGCAUCUUCAGGUGAGUUAGAUAGGACAGAGCGUAGUCCCCCCUUUACACCUCAGACAAAAACUUAAGAAACGUUACUCGCCCAACACAAAACAACUGACUGACCAAGCACCUGUCUUCCCCUCCUCCCAUCCAGGUCUCCUGACUAAUCCCUUCAUCUUUCCAUACCUGGCCCUGACCUCUAGCAGGACCUAAUUCCAUUCAUAACUGUUGAGAGUACACCAUGAGCUACUGAUUCAUAAAAACUCCAAAAAGUGGUUCUUCUGAGGAUGGACUUUAGUGGGAUUCUUUUGACCAGGAAUUAAGGAAAUAAUGUAAAAACACAUGUUAUUGGAUUUAUUAAGCACCUUCCUUGUGCUUAAUAAGUGUUUGAAUUCAGACAUUUCAGGGGUAAGACUACUUAACCUCUGUGUUCCUCUCAACUAUCUAAUGUACACAUACAAAAAUAUGAACAUGGCUGGGCGCGGUGGCUUACACCUGUAAUUCCAGCACUUUGGGACGCCGAGGCGGGCAAAUCACCUGAGGUCAGGAGCUCGAGCCAGCCUGGCCAACAUGGCAAAACCCCAUCUCUACCAAAAAUACAAAAAACUAGCUGGGCGUGGCGGCGAGCGCCUGUAAUCCCAGGUAUUCCGGAAGCUGAGGCAGGAGAAUUGCCUGAACCCGGGAGGCAAAGGUUUUAGUGAGCCGAGAUUGCGCCACUGCACUCCAGCCUGGGGGACAGAGCAAGACUGUUGUCAAAAAAAAAAAAUAUAUAUAUAUACAAACACAUAUAUAUACACAUAUAUAUACAUAUAUACACAUAUAUAUACAUAUAUAUACACAUAUAUAUACAUAUAUAUAUACACACACACAUAUAUAUAUACACACAUACAUAUAUAUAUAUGAAGGCAGUAACAGAGAGAUAAGGUCGAGAAUAACCACCCAUUCCACAGACUAAUAAAGAAUUUAUCUCUUUGCAACUAACAUAGUUUGAAAUGGGAGAUACGGGCUCUUGGAGAGAGUUUUUUCUGGGGUUCUGAAAAGGUCAGAUCCUAUCAAAACACAAUCCACUCACUCAAACAUUUCAGCGUACUCACAUUCUGAGUACUACUGUUUAGUAUGAAAAGAAUUCCAGUGUUACAUGAAGUAAAAAUGGAUUAUCUCAAUCCUCAUGGAAUAUAACGGGACUUGACCAGCAUUUCCUUUUUUUUUUUCCUUCAGUAACUCACUUAUAAGGAAUAAUAGGGUCCUAAUGAGGAUUAAGAUUUAAUAAGGUGUAAUUAGAGUUGUUCAUUUCUUCCAUCAUAUACAUUAUAAGAGUACUGUGCCGGAUCCAGAAAUGCUACUAAUUAUGUUGAAACUGUUGUAUGGGUGUGUUGGGGAAGUCACUGUGUUUCUCCUCCUGAAAUGUUUAUGAAUUGCUCAGGUGAGCAUGGUGAGCAUGGUGUUAGCAUGAACAUCAUAUAAAGUUAACUACAAAAGAAAAAAAAAAAAAAA

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Publications