hsa-mir-4468: Hsa-mir-4468 is identified as a potential candidate reference gene in cancer exosomes [PMC7789813]. In exosomes of ovarian cancer patients, hsa-mir-4468 is found to have the lowest expression level, consistent with the results in exosomes of healthy control individuals [PMC7789813]. Hsa-mir-4468 exhibits high expression stability across samples and tumor types, making it a reliable reference gene [PMC7789813]. In combination with hsa-miR-6835-3p, hsa-mir-4468 shows the highest expression stability in exosomes of patients affected by pancreatic adenocarcinoma (PAAD), hepatocellular carcinoma (HCC), and colorectal cancer (CRC) [PMC7789813]. The study also identifies other potential candidate reference genes for mRNA analyses, including ARF1, B2M, H3F3AP4, ITM2B, MPP1, OAZ1, PCMTD1, SOD2, SERF2 and WIPF1 [PMC7789813]. For miRNA analyses in cancer exosomes other than hsa-mir-4468 and hsa-miR-6835-3p combination mentioned earlier; hsa-miR-125a-5p and hsa-miR192– 3p; as well as hsa-miR4469 and miR67315p are identified as potential candidate reference genes with high expression stability across samples and tumor types [PMC7789813]. These findings provide valuable insights into the selection of reliable reference genes for mRNA and miRNA analyses in cancer exosomes.