Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) long intergenic non-protein coding RNA 1448 (LINC01448) URS000075CCA7_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

LINC01448: LINC01448, a long non-coding RNA (lncRNA), has been implicated in pancreatic cancer (PC) [PMC7843961]. It has been suggested that SOX2 may act as a transcription activator of LINC01448 in PC [PMC7843961]. The expression of SOX2 was found to be positively correlated with the levels of LINC01448 and HK2 in PC tissues [PMC7843961]. LINC01448, miR-505, and HK2 have been identified as potential targets for therapeutic intervention in PC [PMC7843961]. SOX2 has been observed to bind to the promoter region of LINC01448, and there is a positive correlation between the expression of SOX2 and LINC01448/HK2 expression, as well as an inverse correlation between the levels of SOX2 and miR-505 in PC tissues [PMC7843961]. Silencing of LINC01448 led to an increase in miR-505 expression, while overexpression of LINC01448 reduced the levels of miR-505 [PMC7843961]. The study demonstrated that miR-505 functions as a tumor suppressor by targeting HK2, and that oncogenic LINC01448 serves as an upstream inhibitor of miR-505 in PC cells [PMC7843961]. Kaplan-Meier survival analysis showed that low expression of LINC01448 was associated with longer overall survival times in PC patients [PMC7843961]. The study also revealed a direct interaction between miR-505 and LINC01448, with LINC01448 acting as a suppressor to increase HK2 expression [PMC7843961]. The therapeutic inhibition of LINC01448 may be a potential strategy for PC treatment [PMC7843961].

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences
GACGGGGUUUCACCUUGUUAGCCAGGAUGGUCUCGAUCUCCUGACCUCGUGAUCCACCCGCCUCGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGCCACCGCGCCCAGCCUGUAAGCCUAAAUUUUUGUGGCUGUGGGAUGGACAAGGACCCAGUCUUUAGCUGAACUAAGGAAAAGUCCUGCAACAAUAAAUUUCAGAAGUUUGAUCUUAACAGAUGAGGAGACUGAAGCCCACAGAGAUCUGAUAGAAAACAGCUGGAUGUGCUAACAGAGCAUCAGACUUGGAAUCAGGUGGAUCCUAGAUUGGCUACUUCCUAACCUCAGAAAAGUGACAUAAUGUCUAUGGUGAAGUCAUCCAUCUGAAACACAAUGCAGUGAAAUCCACUUUAAAUUUUGAUUGUGAAAGCUUUACUGAGGUUUAUUUGAUACACAAUGAUCGUAUCAUUAUGGCUACAAGAAAAGUAAUCAACAAAGUAUACACUUGGAUAAAUGUUGACAUAAGUAUAUACCUGUAAAACUAUCACUACAAUCAAGAUAAUGAACAUGUCCACGUGCUCCCAAAGUUUCUGCACAAUCCUUCCCAUCCUUCCUUGUUCUUGGAACUGCUAAUCAACUAUAGGUUAGUUUGCAUUUUCUGGAAUUUUAUAUUAAUAGAAUCAUAUAGUGUGGACUCUCUUUGGAGUUUAGUUUCCUUCACUUGGCAUAAUUAUUUUGAGAUUCACCCUUGUUGUGGCAUGUAUCAAUAGUUUAUUCUUAUUUAUUGCUGACUAGUAUUUCAUUGUAUGGGCAUACCACAGUAUGUUUAUUCCUUCAGCUCGUGGUGGAUAUUUAUAUUGUUUCCAGCUUUUUGCCUAUUGUUUUUAAAAGCUGCUAUAAAAAUUGUAUUCAUGUCUUUGCAUGAACAUAUGCUUUUAUUUAUCUUGAGUAAAUGCCUAGGAGUAGAGUGGCUGUAUCAUAAGGUAGAUGUAUAUUUAACUGUUUACGAAACUUGCUGACCAUUUUCCAAUGUGGUUGUAUACUUUACAUUCCCACCAGCAAUGUAUGGGAGUCUAUUCCUCCACAUUCACACCAAUGCUCGAUAUGGUCAGUCUUUAAUUUUAGCCAUUCUAAAAUGUUUGUAGAGUAUCUCAUUGUGUUUUUAAUUUUAAUUAAAUUUCUGAAAUAACAAAAAAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications