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Homo sapiens (human) SBF2 antisense RNA 1 (SBF2-AS1) URS000075CBAD_9606

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SBF2-AS1: SBF2-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including pancreatic cancer, gliomas, glioblastoma, osteosarcoma, and non-small cell lung cancer (NSCLC) [PMC7585082] [PMC6834408] [PMC5613209] [PMC8639705] [PMC8699382] [PMC7352793]. In pancreatic cancer, SBF2-AS1 acts as a competing endogenous RNA (ceRNA) by sponging miRNA-142-3p and upregulating Twinfilin Actin Binding Protein 1 (TWF1), thereby promoting gemcitabine resistance [PMC7585082]. Knock-down of SBF2-AS1 has been shown to decrease the proliferative ability of drug-resistant pancreatic cancer cells [PMC6834408]. In glioblastoma cells, SBF2-AS1 acts as a sponge for miR-151a-3p and enhances DNA double-strand break repair by promoting the expression of X-ray repair cross-complementing 4 (XRCC4), leading to temozolomide resistance [PMC8639705]. Additionally, SBF2-AS1 has been implicated in osteosarcoma and NSCLC progression by modulating the miR-29a/NFIA and miR-122-5p/XIAP signaling cascades, respectively [PMC8699382] [PMC7352793]. The expression of SBF2-AS1 is also associated with the clinical stage of human tumors and can be detected in body fluids such as blood and cerebrospinal fluid [PMC8107676] [PMC8351094]. Furthermore, high expression levels of SBF2-AS1 have been identified as an independent risk factor for low-grade glioma [PMC8226362]. Overall, SBF2-AS1 plays a crucial role in cancer progression and drug resistance in various types of cancer, making it a potential therapeutic target.

Genome locations

Gene Ontology annotations

Sequence

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CAGGUUCCAGCCCCGACCCGGGCGCGCGGGGCCGACUAGGGUCGGGUCCAGUGUGCGGUGGUCGCUCCGCUCCGGGCCGCUCCGCUCUGGGCGUCAGGGCGCGGGGAGCUGCCCCGGGGUUCUGUCCACCGGGGAGGAAAGCCACGAGCACUGAGCGCCUCCUGAGAGCCAGCCCUGACGUGAACUCAUUUUAUCUGCCACGACCCAGAAGGAGUCUACUGCUAAGAUUUCAGCAUGUCCUGUGGCUGAGUUAAUCAGAGUUAUGACAGGAAGGUACCGGGCACACCAUCGCAAUGCUCCAUCAAUGCUAGUAUGUUGUGUUCUUUCCUUCAUAUCAAGUCAACUCAAGCUUGCUCUACUUACCUGGUGUACACAGUCUAAGAACUGUAAGAAGACUGGAGCAAAACCACUCCCCUGACAGUUGAGGGUCAAGCUGCUCCUCUGACUGAAUUUGUGACCAAAAGAGAGCCACUCUUUUUCAACCAACAUCUGGAAGCCUUCAAGUGUCCUAUAAAAGGGAUCACUGAGUAACUGAACCAGGGAUGUCACCUAGGGCAUAAGCAGGAUGGAUUGUCAUUAAUUUUAGUUCUGAAAAAGGCCUAUUACUAAGAUAAAAGCACUUCCUUCUGAUGAUAGCUAAUUCACAAAUUUACCUGGACAGCAAAUUUGUUCACUAACCAUUCCAGGAUGGCCAAUAAAAUUAAUUUUGUAAACUUGCCAGUAAAAACUAAAGCUCAAAUUCAUUUUGGCUACAAGUUUACUUUCAGGGAAUUGAGACUUUAAUCCUUAACUGGCCAGUUUGCUGACAGCAACCUUUUCCUAAGUUAAUCAGAGGCCAGAGGAUCAGUUAAAAUCAAUUCUACUUUUUGGCAGAUGCAGAUUAAUGUCUUAAUGUAGUCUGAACUCACACUUUUCACUCUGGAGUGAGUUAAGGCGGGGCUUAUAGAGAGCCAGGGGAUGGACUGACAAAACCCAGGAAGGAUGGUCCACGCCUCACACUGCUGGUCAAGGGCUCCAUCCGCAAGCCUGCAUGGUACAUCUGUGGAUGGGAGAGCUUGAUGCCCGGAGCCAGAGCUCCAGGCUGCGUAGGGGCUAAGAGCUCAUGGUACGGAGUUUUCUGAUGGAUACCAGGUGCUGUUUAACACAGGACUUUCUCUGUCCAUAAACACAUUAGUCAUUAUACAAAAGAGUCAUCUGAAGAAUUUAAAAAUGACCAAAUGGAAAUAUAAAUAUAAAAUAUCAAAAAAUAUGUCUAAUAGUUUACUUGUGCAGUGAUGUCCCAGCCUUCCUCCAAACAGACCAAAACUGAGGAACCAUUCUCAAGUACUUCUGAUACAACCACAGCCAGCUGCAUUAUCCUGUGAAGCUAAGAGACAGGAAGGAGAACACAAUUAGACCAAGCGCUUUCUGAGUGCAGAAGUCAGAGAGAGUUGCUUUCAACCCUGGAUAAUCAAACGACUUAGGGAUAAAGCGCUUGCACAAAAGAACCACAUAAUGUUUUAAAUACCUAAAGUUCUUUCAAAUCAAGAUUAAACAAUGACACUUUUGACUGGAUGCAAUGACUCAUGCCCAUAAUCCCAGCACUUUGGGAGGCCGAGCCGGGCAGGUCAUUUGAGGUUCGGAGUUCGAGACCAGCCUGGGCAACAUAAGCAAGACCCUGUCUCGAAAAAUAAAAAUAAAAAAGAUACUCCUAUUUGUCUAUACUGUGUACUAAAUGAGAAAAAAACUUUCAAUAUAUUUGUGCUAAGUUUUUAAAGCCACAUCAAUUGGCUCAAAGUCCUUAAUAAACAAUUAAGGUAUGAGAAUAGUAUAUAGAUUUUAAAACCAGAUGUAUAACAUUGUAAUUUUAAAAAAUAUUUUAAUGAUCAUCAGACAUAAUUUGCAAUUUGAAUCCAACUCUGAACAAGAACAAAAAUGAAAAAACCCAUCUCUUAAACAGAGCUAGGCUACUUUAAACACAGGAAUAAGGCAAAUGCCCUACUCAGUAAUGAGAAGCUCCUCAUGUAACUGUUUCUACAACAUAGCUAUCACCAGGCCUGAAUUCUUUUGGGCUCAGAAUUUGUUCUAAGAAAUGGCUAUUAUUAAAAAGUCAAAAAAUAACAGAUGCUGGCGAGCCUGUGGAGAAAAGGGAAUGUAUAUACAUUUCUGGUGGGAAUGUAAAUUAGUUCAGCCAUUGUAGAAAGUAGUUUGGUGAUUUCUCAAAUAACUUAAAACAGAAUUACCAUUUGACCUAGCAAUCCCAUUACUGAGUAUAUACCCAAAGGAAUAUAAAUUGUUCUACCAUAAAGUCACAUGCACACACAUGUUCAGUGCUGUACUAUUCACAAUAGCAAAGACAUGGAGUCAACCUAUAUGCCCAUCAACGGUAGACUGGAUAAAGAAAAUAUGGUACAUAUACACCAUGGAAUACUACACAGCCAUAAAAAGAAUGAGCUUAUGUCCUUUGCAGUAACACAGCUGAAGCAAACUAACACAGGAAUGGAAAACCAAAUACUGCAUAUUCUCACUUAUAAGUGGGAGCUAAACAUUGAGUACACAUGGACACAAAGAAAGGAAUAGACGCCUGGGGCGUAUUUGAGGUUGGAGGUGAGAGGAGGGUGAGGAUAGAAAAACUACCUAUCAGGUACUAUGCUUAUUACCUGGGUGAUGAAAUAAUCUGUACACCAAACUCCCAAGAUAUGCAAUGUACCUAUACAACAAACCUACAU

Taxonomic tree

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