MIR4516: MIR4516 is a microRNA-coding gene that has been implicated in various diseases and biological processes. In a study on autism spectrum disorder (ASD), MIR4516 was identified as one of the candidate-susceptible miRNA-coding genes [PMC9906952]. In gastric cancer (GC), circRNA0047905 was found to bind MIR4516 and miR1227-5p, leading to the activation of the Akt/CREB signaling pathway and promoting disease progression [PMC8305186]. The levels of MIR4516 were found to be significantly associated with osteopaenia and osteoporosis in patients with low bone mineral density (BMD) who had experienced fractures [PMC5976644]. Furthermore, the levels of MIR4516 were decreased in plasma samples from osteoporotic patients compared to non-osteoporotic controls and osteopaenia patients [PMC5976644]. In a study on CD4 T cell latency, an increase in the levels of MIR4516 was observed upon treatment with CCL19 and IL-7, but inhibiting this microRNA did not reverse latency [PMC7926981]. Additionally, MIR4516 has been reported to be involved in regulating epithelial barrier function in intestinal and airway epithelium [PMC9128841]. The down-regulation of MIR4516 was observed along with other genes in various diseases such as autism spectrum disorder, multiple sclerosis, gastric cancer, and others [PMC8874170]. Overall, these findings highlight the potential role of MIR4516 as a biomarker or therapeutic target for various diseases.