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Homo sapiens (human) HOXD antisense growth-associated long non-coding RNA (HAGLR) URS000075C93D_9606

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HAGLR: HAGLR is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases. Knockdown of HAGLR was found to significantly inhibit the relative expression of MAPK1, and this effect could be rescued by the miR-133a-3p inhibitor [PMC9307143]. Conversely, silencing HAGLR was shown to alleviate the inflammatory response induced by IL-1β treatment through targeting miR-130a-3p [PMC10015734]. Overexpression of HAGLR was found to promote the proliferation, migration, and 5-Fu resistance of gastric cancer cells [PMC9300138]. Correlation analysis revealed a positive association between CD8+ T cells and CD4+ memory resting T cells with HAGLR expression [PMC8752260]. HAGLR was identified as a key lncRNA in a network associated with multiple candidate genes in gastric cancer [PMC7653898]. The binding of miR-130a-3p on HAGLR was validated through an RNA pull-down assay [PMC8345017]. In triple-negative breast cancer cells, HAGLR was shown to elevate SRSF1 levels via the ceRNA mechanism to activate the Wnt signaling pathway [PMC8250102]. In lung adenocarcinoma, HAGLR acted as a tumor suppressor by recruiting DNMT1 to inhibit tumor growth through targeting E2F1 promoter [PMC8922926]. Additionally, among autophagy-related lncRNAs, only HAGLR has been reported to be involved in cancer so far [PMC8541751].

Genome locations

Gene Ontology annotations

Sequence

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AGCUGACGAAGGCGCCGUCGCCGUUGCCCAGAGGGAAGGCGGGCUGCAGAGCCACGGGCCGGGCGUCGGAGCGGCAGAACUUGGGUGCCAAGCUGAGCACGUCGCCGCCGACCCCGCCGCUGCUGCUGCAUGACACGUACUCCAGAUCUGGGGACCCUUCACCUGCCUCUACUACUGCAAAUGAUUGGAUAUUCGUCUGACUUGGCUCUUCCCUAAUGUGUGGAACUAAUUUUGUUCACUCUGUUUCAUGCUGGACCUGGCCUGAAAAUGGGCCCUUAUAUUGUCUUUGCACUUUCCAACUUGCCAAGUUUCUGAAAGAAGGACCAAAGUAAUGCCAAGAACUCCCAGAUGAAGAGGACCUUCCUUAGACCUAUAACAGAUUCACUACUUGACUUCAGAGGGAAGUUUCAGCUAAUUCUCAGGAAAAGGUCAAAACAGGCCUGUGACUGUCCCUUGAAUACUGAAGGUAUAAACAAGCUUCUGGCUCCUCCAGGUCAAGCAGAGGAACACUUUUAUUAGAAUGAAGGGUUACUUCUUUGUUAUUCAAACACACACCCACACACAUCCUCUGUAGUCUCCCUAAUGAAAAACCUCAACAGAUGGAGAGCCUGAGCUCCCAAGUCCGCAGGCUGAGAAGAUGCACUUCACUCAAGGGCCAGUGGGCUGGUACAGACUAGGGAAGAGAAAAGGGACAAAGGCUGCUAGUAUAGGUAAUCACUAUCUUUUAAUACUCCUAACACAUAGAAAUUCGAAAAAUCUUGUUCAGCAAUGUUAGCAGCCUGUGAGCCUCGGAAACUAAUUUGGCUGAUGUGUCUCUGAUAGGGAGCUUGGGGCUGCACCAAGGGGAAACAUUCUCCUCCUGUAUUCUCUCCUCUCUCUCGUUUGAAAGCCUGUACAAAGAAAUGGUACAAAUGGAUGGUUAACUUAAUGAUUCCAUCAGAGGCAGAUUUUUCUCUGUCAGGUCCCUGGAUAAGGUGGAGGUCUGAAAGCCAGGAGACAGAAUAUGUACUUAAUCGCCCUUUCUGACCUGCUUACCAGUGACCAGGACUACUCUCCAGGCCUUUCUUCUGCCACUUCCCCAUUCUUCCUGGCUAGUUCAGUUGGGUCUCAGCACUUCAACUCCUGGCUGGAUCCUGAGUUUUUCUUGGUUGCAGGGAAAGCUCUCACUGUCUGCAUCUCCUUCCCCACCCCCACCUCCCGUUUUGCAGCUGGCCAUUCUGGCUGCCUCACAGCUAUCCUGCCUUAAUUCAUAUUUGAUUGCCUGGACAGAACCACCUAGAAUGUCCAGACGACUGCCACCCCUCAGCCAUGGGCCUGAGAUCCUGCCCUGACCCCUUUCUUCAGACCCCAGGAGGACCCACAAUCUCCCUGAUCCCCACCUUCCCCAAAGUAGUCUCUAGGAAAAAAGCAGAGCUGGCUAAGGCCUGAGACAGAGCCAUUUCUUCCCCUUGGGCAAACGAGGUAGACCCUCCCAGAGACCAAUGCCGGAGAGGCCCGGAUCCGAGCUCCCUUUAUAUGGCCUCCCCCAUCACGGAUCCCGUGGGAAAACCUGACACACAAUGGCGCGGCUGCUCCGGGCACCCUCAACCCAGCGCCCUGCGGCAAGGCCUGGAGCAGCCUGGUGGUCUUGGUGCGCUCCCUUUGCCCUCCCCGCAACCCUCUGCGAGCACUCGUCCCAGGAGAGAGACCCUGGCUAGGGUGGAGGUUGCCUCCCGCAAAGGGCGCUGUUGCUGGGGCCUCCCCUCCCCCAUUCUCUUGUUUUUCUGCUUCUGAGACUCGGGAGGGAGGCGGCAGGCGCCUCCGCAGCCGAUAGAGCAGCUAUUGUGACCUUCCCUUGCAGAGCGGGAACCCAGCCGAGUGUGUACCGCCGGCGGUGGCGGGGGAGGAGGCGACUGUGUGUGCAAACCUCAGUCGGAGAGGGGGUGGCGCUGGGAAAUAAAGGUUUGCAACCUCAGGCAGUUGGGCCCUUCAGAGGGCGUUUGGUUGUGUUUAGACUCGGUUGCUUUCUAACACUAAUUGCAGGCUCAAAAGGAGCGGAAUUUAUUGCGAAGGCCAAGGCGGCUUGUUUAUAAUUUAUGAAGUUUUAAAUGGCUGUGCCGCGGGCCCCAACUUUCUCCUGGGCUGGCAGCCGCGCGGAAACGCGCCCUCCCCCGGCUCGCCGCCCACCCCCACCCACGCCCCUCAGAUGAGUCUCACGCCAAUGGCAGGAACAGAUCCGAGCUAUUAGAAGUCUCGGGAACCUCCAGAGAUGACAGAAGGUGGCAGAUUUGGUCCAAGCCCUCACCCCACUCGAGAGGAGGGCGUCGGGGAAAGCUGUGGCUGCCUGGAGAGGGAGCCCCUGAUCCCACACUUCCUUGGAGCCUGAGUGUGAGAGGAAGCUAAUGUCAGCCGGGCUAGACACCGUUUAAAGUCUAAUCCAUGAAACCCUAAGCCGCAAAUGACACUUGGGGCUUUGCAGACACCCGCAGACUCAGCAGAUACUCCUGCGGUAACACACUGUGCUGGAAAACGCCUGGAGCCAUGACACAUUACGUAUUUUUAUUAUUAUUUAUGGUAGGAAGAGGAGAUGAGGGAAAAUCGGGCUGAAUCUAAGCAGCCUGACAAUUCAGCUAGUUAAUAUUUAGCCAGUUAAGAAAGGUGGUUGUAAUCCCUGCAAGGCAGUGAGCUCUCCUUUGAUUUCUCUAAUAGCUUAAAAAAUAAUUUCUUACAAGACAAUUAGAAAUUCUGCCUAUGGAUGCAAAUUUCAUAGAAAACAAUGUUAAGCCUUGAAAGUGGGUAAAAUGUGCCUUCGAUUGAAGUCAUUUAUUCUGUUGAUACACUUCUACAACAUAUAUAUUUUAAACCUGCUCAGAUAAAGUGAAAUUUAGCAAAAGGAUAUCCCCUCCCACCCCCAAAUCUAACAUGCCAUUUUAAAAACAGCACAAAGGAACAAGGAAACUAAAUAUUAUUUUGAGCCAUCAUUACUUAGUGAAAUACAAACAUCCAAAUAGAAACGAUUGUUGUUCCACCAGAAGAUUAGAAGUUAAAUUAUUUCCACACAAUAGGAAUUUCACUUCGUGUCAUCGGGGAUGUAGUAGGAGUUGCAUUAUUUGUCAAACCAAAUAGAGAUGCGUGGGCUGACUUUGCUGAAAUACAAAAGAAUUGAACCUUAUCUGAAGGCGUUUUCUAAGUGGCCCCUCCCAUAGAAGCCGGGAAGUUGUCCACCCCUAGCAGAAGCCACAUUAAUAUUUACAAAAUGGUUAUAAAUCCUUGAAGACAUUUUUGCCCAUUUUGUAUAAGAAACAGGAGUAAACAAGGUGUUUAUACUUGUUAUGUUUCAUUAAUGAAAUAUUAUUACUUUACAUCUUGGGGAAUGUUUGUUUUCUUUAGAAAUGAACUAAUGAUCACUACAAAGGAAGAAUUCAUGACAGCAUUUCCUAGAGAAAAAGCUUAGGUACGCGUCUCCAAAUGAUGGUUUCUUUUUCUACACCUUAGCUUUUUCAUAGCUCAAUUCUUCUUACAACUUCUCUUGUGUUUUUUCUUUGAUUGUCAGUUUUCUUUCAAAGUUUAUUUUUUGUUACUUAAUGCAGAAAAGUGAGCUCUGGUCUCCCCAGUGUAAAAGUCGAUUGUGUCUAGAAAGAAGGCAGUAAAAACAGCAAAGCAGGCGCUGCUUUCAAAAAGCCCUGCCCAAAUCAUCCCGCCCAGAACCUUCUUAGGUUUGCAUCCUCAUUUCCCCCUCCCCUAAUUUCAAUAGCUGGAAAGUAAUCAAGUAUCCCGAGAACCAAUUUAUGCACUAGACUCCAAAUAAAUAAAAUAUUUUUUUCAAAGUGUCA

Taxonomic tree

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Publications