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Homo sapiens (human) glycosaminoglycan regulatory associated long non-coding RNA (GRASLND) URS000075C923_9606

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GRASLND: GRASLND, also known as RNF144A-AS1, is a long non-coding RNA (lncRNA) that has been identified as a regulator of mesenchymal stem cell chondrogenesis [PMC8480077]. It has been reported to play an important role in stem cell chondrogenesis [PMC8525017]. GenePharma (Shanghai) synthesized specific siRNA for GRASLND to study its function [PMC9263572]. The TransScript One step gDNA kit was used to synthesize cDNA for further analysis [PMC9263572]. GRASLND was found to have a significant effect on the regulation of extracellular matrix (ECM) in gastric cancer (GC) cells [PMC9263572]. Knockdown of GRASLND resulted in the downregulation of matrix metalloproteinase 9 (MMP9), a key enzyme involved in ECM regulation [PMC9263572]. The study also showed that GRASLND depletion decreased the invasive capacity of GC cells [PMC9263572]. Furthermore, it was found that knockdown of GRASLND decreased the protein expression of MMP9 and had an impact on the regulation of ECM in GC cells [PMC9263572]. GRASLND has also been implicated in chondrogenesis and cartilage matrix production. It was found to enhance chondrogenesis by suppressing the interferon type II signaling pathway and promoting cartilage matrix production [PMC6769748]. In addition, GRASLND is highly expressed in bladder cancer and its overexpression is associated with poor prognosis [PMC8394133]. Overall, these findings highlight the important role of GRASLND as a regulator in various biological processes, including stem cell chondrogenesis and ECM regulation.

Genome locations

Gene Ontology annotations

Sequence

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ACGCCAUUCUCCUGCCUCAGCCUCCCGAGUAGCUGGGACUACAGGCGCCCGCCACUGCGCCCGGCUAAUUUUUUGUAUUUUUAGUAGAGAGGGGGUUUCACCGUGGUCUCGAUCUCCUGACCUCGUGAUCCGCCCGCCUCAGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGCCACCGCGCCCGGCCAGUUCAAUGGAUUUUAAAAAUUAUUAUUCUCUAGAAAAAAGACCACGAACUUUGGAGUGGACAUCCUGAGACCUGCCUACGAAGACCAUUAGGUGGCCUCCAGAAGACACUCCCCUGAUUCCUACACCGAGGGAACACACAGCAGCAAGCUAGGAAAGAAGGGGUGACCCAGCCCAACGCUGUAAACCAGGGCGCGAACCGGCGUUGAGCUGUGCAGCUGCGCCCUGGGCUCCAGUCCUGCUCUGCCGCAGACCCCACCGGAGCCAGCACCUGCCUCCCCGACCCUCGCUGGGGCGGCUGUGAGAUGAGCCCAGAGCCUUCCUGAGCCAACCCUCGCAAGGAAAGUCUGUCUGUUCACCCCACUAUCCUUGUCUUGAAGGAUGAAGAAAAGAGGGCCCCCCGGGAGGUCCCAAAAGGUGGAAUGGACAUCUGGGAUCCAAGCACAGCAAUUUCUUUAUUUUUCUUAAGCCUCUCACUAGAGGAUGAAAAUCGUUCUGCAUAAAGGCCUGGGCUUUAUGAAAAAUAUAUUCACACCUCCCGUGUCCGAGCUGGGAUACCAAAGAAGUUCCUGGUUGAGUACUACUUAUGAAUGAAGGAUUCAGGGGAUGCACAGGACACAGAGGAAUCUGGGGGAUAUUAUGGUUCUGGGAAUGUGGAAUGUAACGUCUCAUCUUCAGCCCAUCUGUGCUACUGAUCAUCUCAUUCCAGAAGCCAUGCCUUCUCUCAGGAGCAGACAGCACAAGACUUUCCUGCCAGAGGCACAGUCCCCAGUGGGAGUAGCAUCCACAUAAGACAGGAUGCAGAGAUGUCUUCAAGCAGCUUCAAACAAAACUUCAAGAAAGAAAGUGCAAGUGAAAAAGGAAAUUCAUCCUUCCAGUCACUUAACACAGCACUGUCACGGACACCUUGUGCCUCCUUAAAAUUCGUAUACUGAAGUUCUAAGCCCCAGUACCCCAGAAUGUGACCUUCUUUGGAAAUAGGGUCAUUGCAGAUAUGAUUAGUUAAGAGGAGAUCAUACUGGAGUGGGCUUUAAUCCAAUAUGACUGGUGUCCUUAUGUAAAGGGGAAAUUUGGACACAGACACACACAAGGAGAACACCAUGUGAACUGAAGUCAAAGAUUUGGGUGAUGCUUCUACAAGCCAAGAAAUGCCAAAGAUGACCAGCAAAGCACCGGCAGCUGGUGGAGGAGCCUGGACCAGAUUCUUCCUCACAGCCCUCAAAAGGAACCAAUCUUGCCAAAGCUUUGACUUAGACUUCUAGCCCCCUGUGAUGGUUAAUGUUAAGUGGCAGCUUGACUGGGUUAAGGGAUGCCCAGAUAGCUGGUAAGACAGUAUGUCUGUGUGCAUCUCUCAGAGUGUUUCUGGACAAGAUCAGCAUUUGAAUCCUUAGAGUAAAGAAGAUCUGCCCUCACCCACGUGCAUCACCCUAUCUCUGGAGAGCGCGAACAAACAGGAGGAAGGGCACAUAUGCUCCUUCUGUUCCAGCUGGCACAUCCAUCUUCUCCUGCCCCCUGACUUCAGAGCUCCUGGUUCUCGGGCCUCAGGAUUCCAGCACUUACAUGAGAGCGUGCUUCCCCCUCCCUACUCCACCCCUAGGUUCUCCGCCCUUUGGCCUCUGACUGAAUUCCACCACCAGCUUUUCAGGGUCUCCAGCUUGCAGACGGCAGAUCGUGGGACUUCUUGGCCUCCAUAAUUAUGUAAGCCAAUUCCCAUAAUAAAUCUCCUAUCUAUCUAUCUAUCUAUCCAUCUAUCAAUCAUCUAUCUAGUCUAUCUAUCUAUCUAUCUCUAUCCUAUUGAUUCUGUGUCUCUGAGGAACCCUAAUACACCUCCAGAACUGUGAGAUGAUACAUUUCUGUGGUUUAAGCCACUCAGAAGGUGGUACUUUGUUUCACCAGGCCUAGCAAACUAAUACAAGUGCAUGGAAGGUGACUACUCAUGACUGCAACUUAGAGAACAAGGGUUAUAAUAAAAAUAAAAGUGUUAUACAAAGGUGGCAAGAUAAAUGACAAUAAAUGAAAAUAUUAACAUGUGAAUUAAAAAGUAAAGAUAUUUUUCCUAGCAUUCUCCCAGAAAGUAGAGACGCGUCUCUCUUGUUUGCCAUCAUAUCCAGCAAUGGCAAGAUAAGUUCUAGGCACUUCAUAAAAAUUUGUUGAAUGAAAG

Taxonomic tree

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Publications