RMRP: RMRP, a long non-coding RNA, has been found to be deregulated in gastric tumors [PMC6201218]. CRISPR-mediated disruption of RMRP has shown to result in loss of MRP RNA and accumulation of pre-rRNA [PMC5287113]. Deletion of the RMRP gene using CRISPR/Cas9 has definitively shown that it directs the cleavage at site 2 in human pre-rRNA [PMC7277114]. The disappearance of MRP RNA from RMRP targeted CRISPR disruption supports the conclusion that MRP RNA is essential for cell proliferation [PMC5287113]. Disruption of RMRP using CRISPR in HEK293 cells has led to pre-rRNA accumulation and defective ITS1 processing [PMC8814244]. The term \"targeted CRISPR disruption\" is used to describe the editing of RMRP loci by CRISPR guides [PMC5287113]. A high expression level of RMRP has been correlated with advanced tumor grade and low KPS in glioma patients [PMC5701695]. Knockdown of lncRNA RMRP significantly decreased glioma cell proliferation and invasiveness, while inducing apoptosis [PMC5701695]. Expression levels of lncRNA RMRP were significantly increased in glioma tissues compared with normal brain tissues, suggesting its potential role as a diagnostic marker for glioma [PMC5701695