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Homo sapiens (human) NNT antisense RNA 1 (NNT-AS1) URS000075C8F1_9606

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NNT-AS1: NNT-AS1 is a long non-coding RNA (lncRNA) that may exist in exosomes and provide protection to increase its stability in serum [PMC8222968]. Knockdown of NNT-AS1 has been shown to promote apoptosis and inhibit bladder cancer cell proliferation [PMC6949093]. NNT-AS1 can inhibit the expression of genes in the Wnt/β-catenin signaling pathway, such as CTNNB1, CDK1, AXIN2, cyclinD1, and MYC [PMC8767067]. Specific siRNAs targeting NNT-AS1 were obtained from Ambion for knockdown experiments [PMC5356894]. NNT-AS1 has been found to up-regulate podocalyxin-like (PODXL) by sponging miR-1301-3p, which activates Wnt pathway-related proteins [PMC7690676]. Overexpression of NNT-AS1 is correlated with poor prognosis in non-small cell lung cancer (NSCLC) [PMC7977189]. Increased expression of NNT-AS1 has been observed in serum samples from children with recurrent multifocal periostitis (RMPP) compared to those without RMPP [PMC7820231]. In clear cell renal cell carcinoma (ccRCC), NNT-AS1 is downregulated while miR-186-5p is upregulated [PMC8821820]. NNT-AS1 functions as a molecular sponge for miR-22 to regulate FOXM1 expression [PMC7257167]. In triple-negative breast cancer, NNT-AS1 is down-regulated [PMC7690676]. In HepG2 cells transfected with a miR363 inhibitor, NNT-AS1 mRNA expression was increased compared to the control group [PMC5687647]. Upregulation of NNT-AS1 can abolish the effect of miR1236 mimic on cisplatin resistance in lung cancer cells A549/DDP and H522/DDP [PMC7198444]. NNT-AS1 contributes to esophageal squamous cell carcinoma (ESCC) progression by sponging miR-382-5p and positively regulating NNT expression [PMC9586939]. NNT-AS1 functions as a competing endogenous RNA (ceRNA) by sponging miR-496 to increase HMGB1 expression [PMC6949093].

Genome locations

Gene Ontology annotations

Sequence

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AGACCCGGGCUUGGGCCCCGCGGCGCUGCGCCUCCAACCCGGAAGAACAGCCCCAACUCCGCGGCGGCGGGCGGCCACGUGACUGCAGCUCCGCUCCCACCUCGGCCCGCGCCCCUUCCCCGCCCCAGCUUUCUUCCCGCCAGGCCCCCUCCACCCGAUCGCCGCGCGCUCUCCGAACCAAAAGGCGACCUCACGAAAUGCCCCUUUGAGCUCAAAGGCUAGUUACCCCCAGGGGCCCUUCCACUCUCGGGGACAGGCGAAACCUCUUUGUCUCUGCCUCGGCCUGCGGCCCCCAGCCCAGCCUCCGCGCUUUCCCUCCGCCAGUCCUUGUCAAUCAAACCUGGUGCCAAACGCGGCAGCUGAAGUUUUCAGGGACACAUUUGCUUCUCCCCUUGAAGAACCAGUUACAAAGCGUGAUGUCCUCUCUGGGGUCCCAUCAGAACAAAGAAACAGGUCUAAAGACCCUCAUUCCAGAGAGCAUCCUGCCCCAUAUCCAGAAUGAAAUCCAUGCUCAGAGAUGCCAAGAAGAAUCUAGACAGACAGGCCUUUCUAGGCUGUACAAGAAGCAUGAUGCCAGCAUCUGCUUCUGGUGACAACCUCAAGAAGUUUACAAUUGGCCGCGUGCGGUGGCUCAUGCCUGUAAUGCCAGCACUUCGGGAGGCGGAGACAGAUGGAUCAUUUGAGGUCAGGAGUUCGAGACCAGGCUGGCCAACAUGGUGAAACCCCAUCUCUACUAAAAAUACAAAAAUUAGCUGGGCAUGGUGGCAUGUGUCUGGAAUCCCUGCUACUCAGGAGGCUGAGGCAAGAGGAUCACUUGGAACUUGGGAGGCAGAGGUUGCUGUGAGCUGAGAUCACACCACUGUACUCCAGCCUGGGCAACAGAGUGAUACUCUAUCUCAAAAAAAAAAGAAAGAAAGAAAGAAAAGAAAAAGAAGCUUACAAUCAUGGUGGAAGGCGAAGAGGAGGAGCAGGCAUAUCACAUGGCCAAAAAGGGAGCAAGAGAAAGGUGAGAAAGACACUAGACUCUUUUUAAAACCAGCUCUCACAUGAGCUAAUGGAAUAAGAACUCACUCAUUACCACAAGGACAGAACCCAGCCAUUCAUGAGGGACCUGCCACCAUGACCCAAAAACCUCCUACUUGACCCAACCUCCAACACUGGGGAUAACAUUUCAACAUGAGAUUUGAAGAGGACAAAUACUCAAACUAUAUCACUUGUUGUCCAUUUUUAAUCUUUCUCUAACAUACCCUAACUUCUUCUUGAAAAUGCUUAAUUUUCUCUGUUUUGAGAUGUAAAUUUGCUAUCCUGUUUUUCUUAAAACUUGGUAAGAUCUUCAGCCAUGAAGGACAGACAAACUGUAACCUUUCCAUUUACAAAGCUGCAUUUGAAUUCAACUGUCCUUUUAAACUAAGGAGUUUUACUGGUCUCGUGGCUAAAAUUUUAAAGAUGUAGGCCAGGUGCAGUGGCUCAUGCCUGUAAUCCUAUCACUUUUGGAGACCAAGGCGGGGAUGGAUCACCUGAGGUCAGGAGUUCAAGACCAGCCUGGCCAACAUGAUGAAACUCCAUCUCUACUAAAAAUACAAAAAUUAGUCAGGCAUGGUGGCACACACCUGUAAUCCCAGCUACUCGGGAGGCUGAGGCAAGAGAAUGGCUUGAACCCGGGCGACGGAAGUUGCAGUGAGGCGAGAUUGCACCAUUGCACUCCAGCCUGGGCAAUAAGAGUGAAACUCUGUCUCAAAAAAAGAAAAAAUGAUAUAAAGUAUUUAUUUGUGUUUAUAUUUUAUGGAUACGUGUCUAUGUUUAUAGAUUGCCUGUAUGGUACCAACUUGACAUAAAUAAAUUAGUACUCAUAAAUUAAGUAAAUAAGCCCAAACGCUUUUCAAGUUCACAGGGCAUUAGUAAUCUGUGGUAAAUGAAGAUAGUUUAAAAUUUGGGGUAAAAUAAAAUAGAAACAUUUUCUGAAUUUAAUUUAGAUAUUUUUCUGGGUCUAUUUGUUAGACAGGUUUACACUAUCUCUGCUAUUUUUUUAAGGACCUAAAACUGAAUGGACAUAGAAAAUUGAGGAAAGAAAUAAAACCGUAACAAUUAUAAGAGGUUAUAAAAGGUUCAUGGAACCUUUUUAUGUUUUUUCUUGUGCAGUCAAAACCAAUUGCAGGCUGGAUGCAGUAGCUCACACUUGUAAUCCCAGCACUUUGGGAGGCUGAGAUGGGCAGAUCACUUGAGCUCAGGAGUUUGAGACCAUCCUGGGCAACAUAGUGAAACUCUCUCACUACCAAAGUACAAAAGGAAUUAGCUGGGCAUGAUGGUACACACUUGUAGUCCCAGCUACUUGGGGGACUGAGAUGGGAAAAUUGCUUGAGCCCGGGAGUCAAAGGUUGCAGUAAGCCAAGAUUGCACCACUACACUCCAGCCUGGGUGACAAAGUGAGACCCUGUCUCAAAAAAAAACAAAAAAAGGAAAAGAAAACAAUUGCAAUUGGAUUGAUCUGUUUAUAAGGCUUUAUUAAAAUUAGCUUUAGCAUUUAUAAUACACUGGCACAAAGUUAGAAUUUGGAUUUCUCUUUUGAACAAGAUUUUUGUAUACAUUAAUAAGAAAUAGUAAAAGAUUUUUGUUUACCUUUUGAGUAAACUGCAAAAAAUAUUAGUAAUAAGAGGAGAGAAUUUCCCUAAUGCUGUUUUUAUUAUGUCUUUUGAUUGUUUGGAAAACUGAAUCUCCCCUCUGUCAAAGAGUAAAAUUUUUGCUUUUUGAAAUUUUUGAAUUAUCAGUUUGGCUAAAUGAAUAACUAUUAUCUUACAGUGACCUGUAAUCUUAUUUUGAUCAAGUGUUUUAAACCUUUGAUAUUUGACAAACUUCCCAAAAUCAAAUGUAAAAUUCUAACUUAAAUGUUUUCGACCUCAAGCUAACUUUUGGGCAUUAAAGCCCUUGGAAGUCCAAAUAGGGCCCCUGGAAGUCCAAAAGAAACAUAUUAGGCUAAUUUGGUAUAUUAAAAUCAUACAGGAAGCUGAUCAAAUAAAAAAUGUUGUUUAAUUUUCUUUGAGUUGUAUUUGUAUAAAUCUGUUAUUAAUAUGCAUCCCAAAAUUGUAUCAUAUUGCUAAAAUGUUGAUAGAUCUUGUUAUAUGUUAUUGGUAAUAAUUGUUAUCCUGUUAAAUUAUUGUAUACCACAGAAAUAAUGAAAUUUCUUUGUCAAUUGCAUCAGUAAUCAUGGCUCUUCUAAGUCUUUUGUCAUUCACAGAUGAUUAUUGUUUUACUUGGAUUCUUUUCAAAAGUGGUUUGUAAUUGGCUACAGCCUAAAAUCUGCUUGUUC

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Publications