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Homo sapiens (human) ADAMTS9 antisense RNA 2 (ADAMTS9-AS2) URS000075C89F_9606

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ADAMTS9-AS2: ADAMTS9-AS2 is a long non-coding RNA (lncRNA) that has been shown to promote chondrogenic differentiation of human mesenchymal stem cells (hMSC) in vitro and cartilage formation in vivo without the need for TGF-β induction [PMC6838486]. It has also been implicated in various cellular processes, including stress and immune responses, as well as tumor cell evolution [PMC6838486] [PMC8450763] [PMC7346038] [PMC6787165]. Studies have demonstrated that ADAMTS9-AS2 can induce pyroptotic cell death and enhance the sensitivity of gastric cancer cells to cisplatin [PMC7346038] [PMC6787165]. Additionally, ADAMTS9-AS2 has been found to inhibit glioma migration, bladder tumor cell proliferation, and bladder cancer progression [PMC6787165] [PMC7382762] [PMC8492632]. It has also been shown to regulate chemoresistance in clear cell renal cell carcinoma (ccRCC) cells by modulating the miR-27a-3p/NLRP3 axis and affecting autophagy and apoptotic proteins [PMC6710069] [PMC8492632]. Furthermore, ADAMTS9-AS2 has been identified as a prognostic factor for ccRCC diagnosis and is associated with overall survival in ccRCC patients. It can also serve as a biomarker for distinguishing lung adenocarcinoma (LUAD) from non-tumor tissue with high accuracy. However, the mechanistic basis for ADAMTS9-AS2's regulatory activity in triple-negative breast cancer (TNBC) remains to be defined. Overall, ADAMTS9-AS2 plays a complex role in various cancers by modulating different cellular processes.

Genome locations

Gene Ontology annotations

Sequence

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AAACUUGACGUACACACGCAGUCCUAUCCCUACGGUCCUGGAAUUGGGGGUUACUAUCUUGGAAUCUAGGGGCACUCCAGGCUCUGGGCUCAGACGGCUGGCUUCUGCCUACCCGAGCCUUAACCUUUCAAGGACCAGAAGGAUUCCAGAGCUCUUGCCCUAGGUCCUGGGGCAGCGAUGACUCACUGCAGCACCCCCUCCCACUUCGCCAAGCUGCCGUCUCCGCCCACCCCCAAACAAUCUCGACAGCGCAUUUCGGGAGCCACGGCUCCGGGCGCUUUGCUGGGGGCUAAAGGGGUUUAUCCCUUUCCUUGAAUCCCAGCAGGCUAGAACUACCCCCUCCCAGUCUUCAGGCUUGCCACGCUCUCCACCCGAUCCUUCCAUUGAAAGGCAGAGAAGGAAGGAUGUGCUUGGGAACUUUAAGACCCACGAACGACAGCGCACUGAUGGAGCAGCCCAGUGUCUGGGGCAAAGUCCUCGAGGUUCAUUCAUUCAGGAAGCCUCUGACCAGCCUUUACCAUGCGCUGAGUGAGAAGCUGAGGAUAAGGAAAGAGCAAGACCCCCAAGAAACCCUGAUGUCUGGCUGAAAGCCGAAGCAUGACGCAACUUUGCUAUAUUUCUCUCCAACAAGGAUUUGUAUAUUUUCGCUUUCUCCUCAAGUAACACCUGGACCUGCUCCUUUCCCUUCAAACGCUGAGGGCUCAGUCUCCAAGUUCCUUUAUGAAACAGGGUGUACCAUCAGAGACGCAGGUAUUUAUUGAAACCUGCUUUGUGCUGGGCAAUGUGCCAGAUGUUGGGGAUAAAAUGGAGACUUCAGAAAUGAAGAUGCAAAGACAACAGGGGAAACCAUAUAUGUUUAUGGACAGUCAUGCCAAAGUAUGAUUGGAAGACAAAAAGAUUUUUGGCCAAUUCACUGCUCACUAACAUCUCCAUCAAAGGGAAAAACACACAUUGUAAAAUAAGAAUUCUUCAAAGACAACUUGAAGACAUCUGGGAAUUCUGAAGCCUGAAAAUUCCAUGAGUUCAUAGCAGUGUUCACUAAUUCCACUGAUCUAAAGACAAAAAGGAGAGUCAACUGCGUGCCCAAACUCAUUUCUGAUGAUUUCUUCCAUCCUAACUUUUCUGCCUCUCUGGGGGUGGUUAUGCCUGUGAAAAACAUUGAAGCUGUCAGGAACAGAGUCGGCUUUCAAGAUUGGAAUGUCAAAGUAGAGUCUUCUUUUCCUCAGACCAGAAGGGGCUUGGUUGGGUAAGAGUUUCCAGAUCUAAAUGGAGACAGGACUGGGAUAUAGGAGCUUGUACGGAUAAACAACACAAACACCUUGGGUAAGUGAUACACCAAGAGAGAUCAAAAUAGGGUAGGAACACGAUCCUAAAGCUAUGUGAGAUACGAAGCCAAGAGACCCUGUCUACAGGCUGAUAUGUAUUGCAACCAGAGGCCACCUACACUCAAGAAAAUUCUAAAUGAUGUAAUAGGUUGUGGACACUUUCUUGUAAAAAUGAUCGAUAUUUUUUUCUUAUAGGGAUAAAGCUUAAAAGCAUGGGAUGUAUCUCCAUUAGGAAAUAUGAAGUGAGUUGGUAUAUUACAGGUAGGUUAGACUGAGAUAAUUAUAAAACUGGGCUGAUUUUACAUAGAGAAGAACUUGAUUCCUAAAGGUGUUGAAGGACAAGAUGGGGACAGUUAUUGAAGUGUUCAGGUGCUGUCCUUUGUAGUCUGUAGCCUAUUAAAAUAAUACACAACUGAACACAGACCCAAGGAAAGGGGUUCUACUCAUCGCUAGAAUGUAAACUCUAAGAAGAUAAGGAUUUUGUCUGCUUCAUUUAUUACUGUAUUCCCAGCUCCUAAAAGAGUGUCCAGCACUUAGUAUCUGUUGGUAAGUACCUGUUGAAUUAAUUAACCAGUGAUGAGACUUUGGAAAGCAGCUAGUCCAUCUGUAAGAUUGUUUUCUCAUCUGUGAGAUGAGUCAGUUAGAUUAGAUGUUUUCUAAGCUUAUUCUAGUUUUAAAAUUGUAUAUUUCUAUAAGAAAUGAUAAAUGAAAAAUGUCCAUUCCUUUUUCAUCUCCAUCACCCAUCUCACAUCUUCCUUCAGUGCCUAUGUGAUCUGUUUGAGUAUAACCAGGUGUACAAAAGUACUAAGUGAUAUGAGAUGACUUCAGUAGUCCAGGGACUCUUUCUUCCCCCACUCUGUAAAGAGUUAUUUGCUUAAUUUAAUGUACAUUAUAAAAACAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications