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Homo sapiens (human) ZSWIM8 antisense RNA 1 (ZSWIM8-AS1) URS000075C76D_9606

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ZSWIM8-AS1: ZSWIM8-AS1 is a long non-coding RNA (lncRNA) that has been identified as a potential prognostic marker for bladder cancer (BLCA) [PMC8522197]. In a study investigating the prediction of recurrence-free survival (RFS) in BLCA patients, a risk-score formula was developed, which included the expression values of eight lncRNAs, including ZSWIM8-AS1 [PMC6756879]. Tumor tissues from patients with high-risk scores showed higher expression levels of risky lncRNAs, including ZSWIM8-AS1 [PMC6756879]. Conversely, tumor tissues from patients with low-risk scores exhibited higher expression levels of protective lncRNAs, including ZSWIM8-AS1 [PMC6756879]. The negative coefficient for ZSWIM8-AS1 indicated that higher expression levels were associated with longer survival [PMC6756879]. Knockdown of ZSWIM8-AS1 had opposite effects [PMC6756879]. In addition to BLCA, downregulation of ZSWIM8-AS1 has been observed in other cancer subtypes as well [PMC9641000]. The NPInter v4.0 database did not show any target genes for increased expression of ZSWIM8-AS1 in any cancer subtype analyzed [PMC8708613]. Overall, the findings suggest that ZSWIM8-AS1 may serve as a potential prognostic marker for BLCA and other cancer subtypes. Further research is needed to elucidate its functional role and potential therapeutic implications.

Genome locations

Gene Ontology annotations

Sequence

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GAAGGCGCUGCGGGCACUCCGGAUCGCAUUCACAAAGUCGUCGUAGUCCGCAGGAGUCAGUAAACAAAUGAAGAGCUAGAGGAAGGGUCCUCUGAAGAGCCACUGGCACAACUGCAGUCAGGUCAAAUGAUUUACCUGUAAUCCAGGAAACGUGGGAAGAAUAAGUACGUGAGAGCCAGUUGGGAGAAACAAAGUUGUGCAGGCCAAGGGCAUAAAGCCCAAUCUCGAAGGCGCAAAGGUGCAGGUUGCGGUGAGGACCCUGGUGGCCCCCUGAGGAAGAUGGAUGUGUGAAAAUGGAAGUGCUGCUGUUGCCCCCUGCCUUGAUCAGCACUGUCUUCGCCAGCUCGAAGUAGAAGUGUGCAGCUGCCUCUGAUGGCUGAUUGGUCUUCGCCCGGGCUCCUCCACUGGCACUGGCCCGGCGACUUCCACUGGAGGAUGAGGAGCCCAGGGAGUCCGAAGAAGAGCUGCUAAUGCUGUCACUGUCCUGACCUCGACCCCAGGAGGUGGGGGCCCAGCCCCCUCGAAGUGGUCUCCGGCUUAAGGUGGGGGAACUAUCCGAUGUUGUUUCAGGGGCACUGCUGUCAAUGCUGGCCAUGCCUAACCCCCAAGAGAAGUCAGUCUCAGAAGUCAGGAGUCCCAGAUGUUAAGACUCCAACCUUCAGGAUUAUCCUUCCCUCUAUGCUAGCCCACAGGCUAUCCUACCUGUGUGCUUCUUCUUAGGCCGUCCUGGGGACCCCCAUCCCCGUCCAUUAUAGCCUCCACGACUGCCAAGUGCCAAGCGGCUAGGAACCUUCCCUUCUGGCCUUGGGGUCAAAGCUGCCUCAGAUGGAAGACCCUCACAGGGGGAAUGUGGGGAACUCUCUAGGUGAGGAAAACAGGACGCUGGGAUGAGCCCAGGAAAGGGGACCUCAACAUAGGUCCACACCAUUCAUCCCCCCUGCCCAGUGCCCCCACCUCACCAGGCACAUUCUUCUCUGUGAAGCCCUCAGUGGGGCCUGGCCCAGCCCCUGCCACACUCCCUGGUUGAGCAGGCCCUGCAGAGCCUGAGGUCAGUGGUUGCAGGGCCCCUGGGGCAGAUGGGCCCCCGUGCUUUGAAGGAGACCUCUGGCUGGCUGUGGUUGGGCGGCUAGAUGAGUAGAAAGAACUCAGCGUCUGUGGCUUAUGUGUCUGGCUCUCUCGGUCCAAGAGUUUGUCUAAGAUCUGGAAGACAGAAGCAGUGACCUCCAGAGAAGCAGUGACAGGAUGCCCUUUAGCUCCUGACUUCUAUUACCUUCCUUUCUCCUUGAAACAGCCAAUUGCUACAUCCUCAGGGAGCCUUCCCCACUUACAACCACAGGAUGACCUCCUGGUUUACAUGUCUUUUUGUAACUUAUUUAACCCCAACAUAUCUUGGUAUCCUCCAUUAACACCACAGGGCAGAAUAUACUGAUAGUCAAUAAAUACUGAAAUAAGUGAAUGAAAAAAAAAAAAAAAAAA

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Publications